INT137271

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Context Info
Confidence 0.29
First Reported 2004
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.95
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE6B) signal transduction (PDE6B)
Anatomy Link Frequency
photoreceptor 1
dental pulp 1
PDE6B (Homo sapiens)
Pain Link Frequency Relevance Heat
pulpitis 18 99.90 Very High Very High Very High
ketamine 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulpitis 18 99.90 Very High Very High Very High
Injury 3 98.56 Very High Very High Very High
Retina Disease 13 97.96 Very High Very High Very High
Blindness 20 97.16 Very High Very High Very High
Disease 12 52.64 Quite High
Ocular Toxicity (including Many Sub-types) 11 48.72 Quite Low
Retinal Diseases 7 30.72 Quite Low
Leber Congenital Amaurosis /

Leber Congenital Amaurosis

17 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results point to a role of cGMP PDE in the initial pulp response after injury.
Positive_regulation (role) of cGMP PDE associated with injury
1) Confidence 0.29 Published 2004 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 16857102 Disease Relevance 0.63 Pain Relevance 0.53
In reversible pulpitis the cGMP PDE activity increased almost 3 times.
Positive_regulation (increased) of cGMP PDE associated with pulpitis
2) Confidence 0.29 Published 2004 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 16857102 Disease Relevance 0.55 Pain Relevance 0.55
Mutations in the AIPL1 gene destabilize cGMP PDE and lead to photoreceptor dysfunction and a rapid retinal degeneration in mouse [8,9] and human [10].
Positive_regulation (destabilize) of cGMP PDE in photoreceptor associated with retina disease
3) Confidence 0.28 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1463903 Disease Relevance 0.33 Pain Relevance 0
High levels of cGMP PDE are found in dental pulp cells.
Positive_regulation (levels) of cGMP PDE in dental pulp
4) Confidence 0.27 Published 2004 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 16857102 Disease Relevance 0.44 Pain Relevance 0.44

General Comments

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