INT137400

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Context Info
Confidence 0.52
First Reported 2003
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 16
Total Number 18
Disease Relevance 9.19
Pain Relevance 9.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mtx1)
Anatomy Link Frequency
blood 1
superior 1
Paneth cells 1
goblet cells 1
Mtx1 (Mus musculus)
Pain Link Frequency Relevance Heat
methotrexate 1414 100.00 Very High Very High Very High
adenocard 22 99.40 Very High Very High Very High
rheumatoid arthritis 158 98.88 Very High Very High Very High
Arthritis 666 98.60 Very High Very High Very High
Inflammation 59 97.92 Very High Very High Very High
Adalimumab 40 96.68 Very High Very High Very High
Leflunomide 18 96.64 Very High Very High Very High
Pain 71 96.16 Very High Very High Very High
cytokine 14 95.24 Very High Very High Very High
spinal inflammation 1 93.16 High High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 214 98.88 Very High Very High Very High
Juvenile Chronic Polyarthritis 574 98.60 Very High Very High Very High
Sacroiliitis 6 97.96 Very High Very High Very High
INFLAMMATION 76 97.92 Very High Very High Very High
Pain 46 96.16 Very High Very High Very High
Spondylarthritis 3 95.44 Very High Very High Very High
Renal Disease 18 94.20 High High
Disease 191 93.60 High High
Low Back Pain 3 93.16 High High
Arthritis 88 86.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The blood MTX level was not affected by concomitant use of any other drugs.
Neg (not) Regulation (affected) of MTX in blood associated with methotrexate
1) Confidence 0.52 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2638602 Disease Relevance 0.66 Pain Relevance 0.54
Evaluation of the effects of MTX dose increase [18]
Regulation (effects) of MTX associated with methotrexate
2) Confidence 0.38 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2638602 Disease Relevance 1.05 Pain Relevance 0.97
A systematic review was conducted on the effects of MTX therapy on mechanical capabilities, range of motion, quality of life, overall satisfaction and pain in JIA patients.
Regulation (effects) of MTX associated with pain, methotrexate and arthritis
3) Confidence 0.38 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2638602 Disease Relevance 0.72 Pain Relevance 0.61
The age-related changes in MTX kinetics revealed by these studies may explain this finding.


Regulation (changes) of MTX associated with methotrexate
4) Confidence 0.38 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2638602 Disease Relevance 0.54 Pain Relevance 1.36
Evaluation of the influence of concomitant use of folic acid on the clinical efficacy of MTX [21]
Regulation (influence) of MTX associated with methotrexate
5) Confidence 0.38 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2638602 Disease Relevance 0.62 Pain Relevance 0.94
Some textbooks also refer to the efficacy of MTX in the treatment of polyarticular JIA.
Regulation (efficacy) of MTX associated with methotrexate and arthritis
6) Confidence 0.23 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2638602 Disease Relevance 0.49 Pain Relevance 0.60
The initial target of MTX to be identified was dihydrofolate reductase (DHFR), which forms tetrahydrofolate, a precursor required for one carbon donation for synthesis of thymidylate, purines, methionine and serine, remethylation of homocysteine to form methionine, and provision of methyl donors for multiple methyltransferase enzymes [29].
Regulation (target) of MTX associated with methotrexate
7) Confidence 0.19 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958653 Disease Relevance 0.31 Pain Relevance 0.41
Additionally, having a better understanding of how cellular folate concentrations and patterns change with age may also help explain the variation seen in MTX response.
Regulation (response) of MTX associated with methotrexate
8) Confidence 0.19 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958653 Disease Relevance 0.17 Pain Relevance 0.14
The unusual databases from Jyväskylä, Finland and by T.P. in Nashville, TN, USA, provided an opportunity to document changes in MTX therapy over the years.
Regulation (changes) of MTX
9) Confidence 0.17 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2544432 Disease Relevance 0.40 Pain Relevance 0
RESULTS: The effects of MTX, SSZ and BUC on clinical parameters were monitored over the first three months, and in particular, NPJs and NSJs were found to decrease significantly during single agent MTX or BUC treatment over 108 months.
Regulation (effects) of MTX
10) Confidence 0.17 Published 2006 Journal Clin. Exp. Rheumatol. Section Body Doc Link 16870092 Disease Relevance 0 Pain Relevance 0
In contrast, both MTX [45] and DOX hardly affect the expression of lysozyme by Paneth cells in the crypts (data not shown).
Regulation (affect) of MTX in Paneth cells associated with methotrexate
11) Confidence 0.16 Published 2007 Journal Dig Dis Sci Section Body Doc Link PMC1914222 Disease Relevance 0.33 Pain Relevance 0.29
Studies to date indicate that the most important actions of low-dose MTX are its effects on increasing adenosine level and reducing the pro-inflammatory while simultaneously increasing the anti-inflammatory cytokine levels.
Regulation (effects) of MTX associated with adenocard, inflammation, methotrexate and cytokine
12) Confidence 0.14 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615375 Disease Relevance 1.12 Pain Relevance 0.94
All 544 patients included had inadequate responses to MTX and 3 other DMARDs.
Regulation (responses) of MTX associated with methotrexate
13) Confidence 0.13 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2377247 Disease Relevance 0.48 Pain Relevance 0.95
Two other studies have examined the use of MTX for the induction of remission in WG.
Spec (examined) Regulation (use) of MTX associated with methotrexate
14) Confidence 0.12 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165064 Disease Relevance 0.66 Pain Relevance 0.28
each group (treated and controls of MTX and/or CsA) after a gentle massage of the abdominal
Regulation (controls) of MTX associated with methotrexate
15) Confidence 0.12 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2266974 Disease Relevance 0.09 Pain Relevance 0.18
Efficacy of SLZ and MTX (alone or combination) on the treatment of active sacroiliitis in early AS.
Regulation (Efficacy) of MTX associated with sacroiliitis and methotrexate
16) Confidence 0.10 Published 2009 Journal Rheumatol. Int. Section Title Doc Link 19593568 Disease Relevance 1.15 Pain Relevance 0.62
Moreover, the cell-fate specific affect of MTX on goblet cells causing goblet cells to accumulate in the crypt and at the top of the villus [45, 46] was not seen after DOX treatment.
Regulation (affect) of MTX in goblet cells associated with methotrexate
17) Confidence 0.10 Published 2007 Journal Dig Dis Sci Section Body Doc Link PMC1914222 Disease Relevance 0.22 Pain Relevance 0.31
However, as the superior efficacy of SC administered MTX has been proven in a recent 6-month, multicenter, randomized, double-blind, controlled trial in comparison to oral MTX in 384 MTX-naïve patients with active RA [5], similar clinical results can be expected for the novel HC formulation.
Regulation (controlled) of MTX in superior associated with rheumatoid arthritis and methotrexate
18) Confidence 0.04 Published 2010 Journal The Open Rheumatology Journal Section Body Doc Link PMC2866241 Disease Relevance 0.18 Pain Relevance 0.30

General Comments

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