INT137529

Context Info Confidence 0.30 First Reported 2006 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 3.73 Pain Relevance 0.12

extracellular space (MICA) plasma membrane (MICA) cytoplasm (MICA)

Anatomy Link Frequency epithelial cells 2 MICA (Homo sapiens)

Pain Link Frequency Relevance Heat agonist 11 91.12 corticosteroid 6 87.88 cytokine 30 64.28 spinal inflammation 2 50.00 Multiple sclerosis 158 5.00 Inflammation 43 5.00 Central nervous system 27 5.00 cINOD 7 5.00 Inflammatory response 7 5.00 tolerance 5 5.00

Disease Link Frequency Relevance Heat Stress 21 100.00 Nicotine Addiction 273 98.88 Pulmonary Disease 261 98.48 Cancer 11 94.16 Cytomegalovirus Infection 1 93.36 Sarcoma 1 89.44 Viral Infection 5 86.04 Low Back Pain 2 85.96 Lung Cancer 6 82.32 Disease 74 37.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The frequency of MICA*007 was significantly increased in AS patients, when compared with normal controls (chi-square=10.18, P<0.05, RR=2.50).

Positive_regulation (increased) of MICA

1) Confidence 0.30 Published 2006 Journal Zhonghua Yi Xue Yi Chuan Xue Za Zhi Section Body Doc Link 16883538 Disease Relevance 0.09 Pain Relevance 0

We did not detect an upregulation of MICA in bronchial biopsies from smokers or COPD subjects, and MICB was undetectable in all samples.

Positive_regulation (upregulation) of MICA associated with pulmonary disease and nicotine addiction

2) Confidence 0.21 Published 2010 Journal Respir Res Section Body Doc Link PMC2955660 Disease Relevance 1.29 Pain Relevance 0.09

We hypothesize that the bronchial epithelium is not activated in terms of MICA or MICB, in our subjects with stable COPD.

Positive_regulation (activated) of MICA in epithelium associated with pulmonary disease

3) Confidence 0.15 Published 2010 Journal Respir Res Section Body Doc Link PMC2955660 Disease Relevance 1.07 Pain Relevance 0

The NKG2 D ligands, MICA and B, are stress-inducible and primarily expressed on epithelial cells [32].

Positive_regulation (inducible) of MICA in epithelial cells associated with stress

4) Confidence 0.14 Published 2010 Journal Respir Res Section Body Doc Link PMC2955660 Disease Relevance 0.69 Pain Relevance 0

-UTR sequences and maintains expression of MICA and MICB protein under a certain threshold and facilitates acute upregulation of MICA and MICB during cellular stres [142].

Positive_regulation (upregulation) of MICA

5) Confidence 0.08 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.60 Pain Relevance 0.03

General Comments

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