INT137616

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Context Info
Confidence 0.67
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 9.37
Pain Relevance 2.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (Cd38) plasma membrane (Cd38) nucleus (Cd38)
Anatomy Link Frequency
smooth muscle 1
lymphocyte 1
Cd38 (Mus musculus)
Pain Link Frequency Relevance Heat
Intracerebroventricular 2 99.98 Very High Very High Very High
Potency 1 99.08 Very High Very High Very High
Antinociceptive 2 98.92 Very High Very High Very High
Morphine 9 98.56 Very High Very High Very High
tolerance 6 95.88 Very High Very High Very High
cytokine 87 95.68 Very High Very High Very High
antinociception 3 95.32 Very High Very High Very High
agonist 47 89.44 High High
Inflammation 72 84.80 Quite High
adenocard 22 82.24 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 455 99.80 Very High Very High Very High
Renal Disease 352 98.64 Very High Very High Very High
Leukemia 11 97.76 Very High Very High Very High
Hyperinsulinism 11 97.72 Very High Very High Very High
Heart Rate Under Development 20 95.80 Very High Very High Very High
Neuroblastoma 15 94.20 High High
Diabetes Complications 77 93.16 High High
Asthma 35 93.12 High High
Chronic Renal Failure 55 91.96 High High
Hyperglycemia 22 91.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We first showed that morphine's antinociceptive potency was increased by the intracerebroventricular injection of CD38 substrate beta-NAD(+) in mice.
Gene_expression (injection) of CD38 associated with intracerebroventricular, antinociceptive, potency and morphine
1) Confidence 0.67 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20551293 Disease Relevance 0.12 Pain Relevance 1.29
The transmembrane glycoprotein CD38 in airway smooth muscle is the source of cyclic-ADP ribose, an intracellular calcium-releasing molecule, and is subject to regulatory effects of cytokines such as interleukin (IL)-13, a cytokine implicated in asthma.
Gene_expression (source) of CD38 in smooth muscle associated with asthma and cytokine
2) Confidence 0.65 Published 2006 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 16891391 Disease Relevance 0.17 Pain Relevance 0.19
surface expression of CD38 [46].
Gene_expression (expression) of CD38
3) Confidence 0.63 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2656910 Disease Relevance 0.70 Pain Relevance 0.11
CD38 is strongly expressed in lymphocyte
Gene_expression (expressed) of CD38 in lymphocyte
4) Confidence 0.63 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2656910 Disease Relevance 0.65 Pain Relevance 0.10
In addition, CD38 expression has been reported
Gene_expression (expression) of CD38
5) Confidence 0.63 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2656910 Disease Relevance 0.76 Pain Relevance 0.12
CD38 autoantibodies possibly stimulate both insulin rsecretion resulting in hyperinsulinemia, the prominent
Gene_expression (autoantibodies) of CD38 associated with hyperinsulinism
6) Confidence 0.54 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2656910 Disease Relevance 0.86 Pain Relevance 0
In

PBMCs, binding of agonistic anti-CD38 antibodies, which stimulate ADPRCA,

Gene_expression (antibodies) of CD38
7) Confidence 0.54 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2656910 Disease Relevance 1.01 Pain Relevance 0.17
factors independent of diabetes, including CD38 genetic polymorphisms and
Gene_expression (polymorphisms) of CD38 associated with diabetes mellitus
8) Confidence 0.54 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2656910 Disease Relevance 0.83 Pain Relevance 0
anti-CD38 autoantibodies in type 2 diabetic patients was associated with
Gene_expression (autoantibodies) of CD38 associated with diabetes mellitus
9) Confidence 0.54 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2656910 Disease Relevance 0.53 Pain Relevance 0
effects of CD38 and CD157 and increased numbers of differentiated cells.
Gene_expression (effects) of CD38
10) Confidence 0.54 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2656910 Disease Relevance 0.58 Pain Relevance 0.05
relationship between CD38 autoantibodies and diabetic vasculopathy as agonistic
Gene_expression (autoantibodies) of CD38 associated with diabetes mellitus
11) Confidence 0.54 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2656910 Disease Relevance 0.80 Pain Relevance 0
anti-CD38 autoantibodies should show lower frequencies of diabetic nephropathy,
Gene_expression (autoantibodies) of CD38 associated with renal disease
12) Confidence 0.54 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2656910 Disease Relevance 0.90 Pain Relevance 0
ADP-ribosyl-cyclase activity (ADPRCA) of CD38, CD157, and other
Gene_expression (activity) of CD38
13) Confidence 0.54 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2656910 Disease Relevance 0.71 Pain Relevance 0.16
Cells were analyzed for the expression of surface markers like Annexin V, CD34, CD38, Bcl-2, CD33, CD19 and CD3 (BD pharmingen- San Jose, California).
Spec (analyzed) Gene_expression (expression) of CD38
14) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923186 Disease Relevance 0.18 Pain Relevance 0.03
and IL-13 also upregulated CD38 expression and function in HASMCs [48,53-56].
Gene_expression (expression) of CD38
15) Confidence 0.30 Published 2010 Journal Respir Res Section Body Doc Link PMC2922094 Disease Relevance 0 Pain Relevance 0.25
10, Dako), mouse anti-human CD42b:RPE-Cy5 and mouse anti-human CD38:RPE or mouse anti-human CD66:RPE.
Gene_expression (anti) of CD38
16) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0.17 Pain Relevance 0.03
100, to detect the activated GPIIb/IIIa receptor, Becton Dickinson, San Jose, CA), mouse anti-human CD42b:RPE-Cy5 and mouse anti-human CD38:RPE (1?
Gene_expression (human) of CD38
17) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0.16 Pain Relevance 0
100, BD Biosciences) [18], mouse anti-human tissue factor CD142:RPE and mouse anti-human CD42b:FITC or mouse anti-human CD38:FITC, alternatively mouse anti-human CD66:FITC, simultaneously or isotype controls IgG1:FITC and IgG1:PE (all from BD Biosciences).


Gene_expression (anti) of CD38
18) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0.07 Pain Relevance 0.04
100, to detect the activated GPIIb/IIIa receptor, Becton Dickinson, San Jose, CA), mouse anti-human CD42b:RPE-Cy5 and mouse anti-human CD38:RPE (1?
Gene_expression (human) of CD38
19) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0.16 Pain Relevance 0

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