INT137670

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Context Info
Confidence 0.68
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 3.42
Pain Relevance 1.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpv4) plasma membrane (Trpv4) cilium (Trpv4)
transmembrane transport (Trpv4)
Anatomy Link Frequency
neurons 2
skin 2
oocytes 2
Trpv4 (Mus musculus)
Pain Link Frequency Relevance Heat
Dorsal horn neuron 2 98.04 Very High Very High Very High
Hyperalgesia 29 97.64 Very High Very High Very High
central sensitization 4 96.24 Very High Very High Very High
Pain 16 88.56 High High
spinal dorsal horn 38 83.36 Quite High
Spinal cord 16 83.36 Quite High
dorsal root ganglion 92 80.16 Quite High
TRP channel 119 78.80 Quite High
Hippocampus 12 73.96 Quite High
imagery 27 70.44 Quite High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 48 99.80 Very High Very High Very High
Hyperalgesia 42 97.64 Very High Very High Very High
Disease 13 90.40 High High
Pain 13 88.56 High High
Diabetes Mellitus 4 88.24 High High
Ganglion Cysts 92 80.16 Quite High
Hypersensitivity 6 69.84 Quite High
Targeted Disruption 34 69.44 Quite High
INFLAMMATION 25 68.84 Quite High
Depression 8 62.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To address the question of whether the TRPP2 effect on swelling-activated currents is simply mediated through increased surface expression of TRPV4, we inserted a V5 tag into the first extracellular loop of TRPV4 and TRPP2, respectively, and monitored either ion channel at the cell surface using a modified ELISA system (Wegierski et al., 2006).
Positive_regulation (increased) of Gene_expression (expression) of TRPV4 associated with pressure and volume under development
1) Confidence 0.68 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.41 Pain Relevance 0
To address the question of whether the TRPP2 effect on swelling-activated currents is simply mediated through increased surface expression of TRPV4, we inserted a V5 tag into the first extracellular loop of TRPV4 and TRPP2, respectively, and monitored either ion channel at the cell surface using a modified ELISA system (Wegierski et al., 2006).
Positive_regulation (mediated) of Gene_expression (expression) of TRPV4 associated with pressure and volume under development
2) Confidence 0.68 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.41 Pain Relevance 0
However, flow-induced Ca2+ signals were virtually abolished in the same cells after the induction of TRPV4 siRNA expression by tetracycline (Fig. 3, C, E, G, and H).
Positive_regulation (induction) of Gene_expression (expression) of TRPV4
3) Confidence 0.68 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.07 Pain Relevance 0
Thus, the increases in swelling-induced conductance are not the result of increased TRPV4 surface expression but rather caused by altered channel properties through formation of TRPP2/TRPV4 heteromers.
Neg (not) Positive_regulation (increased) of Gene_expression (expression) of TRPV4 associated with pressure and volume under development
4) Confidence 0.68 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.18 Pain Relevance 0.04
Therefore, enhanced expression and function of TRPV4 will result in increased excitability of spinal dorsal horn neurons, which may contribute to central sensitization.
Positive_regulation (enhanced) of Gene_expression (expression) of TRPV4 in neurons associated with central sensitization and dorsal horn neuron
5) Confidence 0.59 Published 2009 Journal Mol Pain Section Body Doc Link PMC2650694 Disease Relevance 0.38 Pain Relevance 0.45
This compound also activated TRPV4 currents in cell-free outside-out patches from HEK293T cells overexpressing TRPV4 cDNA, suggesting that BAA can activate the channel in a membrane-delimited manner.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of TRPV4
6) Confidence 0.50 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16899456 Disease Relevance 0 Pain Relevance 0.13
Interestingly, coexpression of TRPV4 significantly increased TRPP2 surface expression (Fig. 2 G), whereas TRPP2 reduced both TRPV4 surface expression and TRPV4 total protein levels (Fig. 2 I).
Positive_regulation (increased) of Gene_expression (coexpression) of TRPV4
7) Confidence 0.49 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.29 Pain Relevance 0.03
A somewhat unexpected observation in this study was the increased ubiquitination of TRPV4 upon ?
Positive_regulation (increased) of Gene_expression (upon) of TRPV4
8) Confidence 0.47 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0
Coexpression of TRPV4 and TRPP2 significantly augmented the swelling-activated currents in X. laevis oocytes, whereas steady-state currents remained unchanged (Fig. 2 A).
Positive_regulation (augmented) of Gene_expression (Coexpression) of TRPV4 in oocytes associated with pressure and volume under development
9) Confidence 0.46 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.45 Pain Relevance 0
However, whether TRPV4 expression is required in skin cells or DRGs is unsettled [27].
Positive_regulation (required) of Gene_expression (expression) of TRPV4 in skin
10) Confidence 0.44 Published 2007 Journal Mol Pain Section Body Doc Link PMC2222610 Disease Relevance 0.69 Pain Relevance 0.69
PKC activation by phorbol ester derivatives induced Ca2+ influx in HEK 293 cells transfected with human TRPV4 cDNA and exposure to a hypotonic solution after phorbol myristate acetate incubation further increased intracellular Ca2+ [32].
Positive_regulation (transfected) of Gene_expression (transfected) of TRPV4
11) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2650694 Disease Relevance 0.55 Pain Relevance 0.41
In addition TRPV4 transcripts were found at high levels in these two organs.
Positive_regulation (levels) of Gene_expression (found) of TRPV4
12) Confidence 0.37 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0 Pain Relevance 0.03

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