INT137671

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Context Info
Confidence 0.58
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.25
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpv4) plasma membrane (Trpv4) cilium (Trpv4)
transmembrane transport (Trpv4)
Trpv4 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 5 86.32 High High
TRP channel 9 76.48 Quite High
Pain 7 68.24 Quite High
Hyperalgesia 23 65.84 Quite High
qutenza 4 52.96 Quite High
Lasting pain 1 41.12 Quite Low
Inflammation 7 38.88 Quite Low
nociceptor 4 32.24 Quite Low
Neuropathic pain 2 19.92 Low Low
allodynia 2 16.96 Low Low
Disease Link Frequency Relevance Heat
Pain 6 68.24 Quite High
Hyperalgesia 26 65.84 Quite High
Nociception 6 51.52 Quite High
INFLAMMATION 7 38.88 Quite Low
Injury 2 25.08 Quite Low
Neuropathic Pain 4 19.92 Low Low
Burns 1 14.24 Low Low
Stress 4 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another related compound, andrographolide, found in abundance in the plant Andrographis was unable to activate or block activation of TRPV4 channels.
Negative_regulation (block) of Positive_regulation (activation) of TRPV4
1) Confidence 0.58 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16899456 Disease Relevance 0 Pain Relevance 0.11
-arrestin 1 inhibits the angiotensin-induced increase in the interaction between TRPV4 and AIP4.
Negative_regulation (inhibits) of Positive_regulation (increase) of TRPV4
2) Confidence 0.40 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0
M, AP18 was unable to appreciably block activation of TRPV1, TRPV2, TRPV3, TRPV4, or TRPM8 (Figure 2).
Negative_regulation (block) of Positive_regulation (activation) of TRPV4
3) Confidence 0.27 Published 2007 Journal Mol Pain Section Body Doc Link PMC2222610 Disease Relevance 0.25 Pain Relevance 0.37

General Comments

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