INT1378

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Context Info
Confidence 0.43
First Reported 1977
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 27
Total Number 29
Disease Relevance 9.16
Pain Relevance 9.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Prl)
Anatomy Link Frequency
plasma 6
hypothalamus 4
PES 2
face 2
endocrine systems 2
Prl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
methadone 18 100.00 Very High Very High Very High
fluoxetine 14 100.00 Very High Very High Very High
antagonist 15 99.98 Very High Very High Very High
Cluster headache 6 99.92 Very High Very High Very High
Dynorphin 8 99.84 Very High Very High Very High
dexamethasone 4 99.84 Very High Very High Very High
opiate 11 99.42 Very High Very High Very High
withdrawal 2 99.40 Very High Very High Very High
Serotonin 27 99.28 Very High Very High Very High
drug abuse 2 98.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 14 100.00 Very High Very High Very High
Prolactinoma 6 99.92 Very High Very High Very High
Cluster Headache 6 99.92 Very High Very High Very High
Obesity 12 99.84 Very High Very High Very High
Coronary Artery Disease 18 99.72 Very High Very High Very High
Eating Disorder 14 99.24 Very High Very High Very High
Pituitary Cancer 2 99.04 Very High Very High Very High
Heart Rate Under Development 1 98.94 Very High Very High Very High
Drug Dependence 2 98.68 Very High Very High Very High
Empty Sella Syndrome 6 97.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both the prolactin (Prl) response to ether and the Prl response to mating were suppressed by L-dopa.
Negative_regulation (suppressed) of Regulation (response) of Prl
1) Confidence 0.43 Published 1979 Journal Neuroendocrinology Section Abstract Doc Link 440533 Disease Relevance 0.17 Pain Relevance 0.19
Combinations of formalin injection with immobilization also show an attenuated PRL response.
Negative_regulation (attenuated) of Regulation (response) of PRL
2) Confidence 0.43 Published 2007 Journal Neuroendocrinology Section Abstract Doc Link 17556846 Disease Relevance 0.41 Pain Relevance 0
Depletion of serotonin stores by pretreatment with p-chloro-phenylalanine methyl-ester (PCPA; 3 x 300 mg/kg ip) significantly prevent the effect of quipazine on prolactin levels.
Negative_regulation (prevent) of Regulation (effect) of prolactin associated with serotonin
3) Confidence 0.43 Published 1988 Journal Pol J Pharmacol Pharm Section Abstract Doc Link 2467272 Disease Relevance 0 Pain Relevance 0.48
Both fluoxetine and indalpine inhibited the effect of fenfluramine on plasma prolactin levels, but did not modify the effect of fenfluramine on plasma corticosterone levels.
Negative_regulation (inhibited) of Regulation (effect) of prolactin in plasma associated with fluoxetine
4) Confidence 0.43 Published 1985 Journal Neuroendocrinology Section Abstract Doc Link 2931613 Disease Relevance 0 Pain Relevance 0.52
There was a 34% inhibition of the effect of fenfluramine on plasma prolactin levels, but this effect was not statistically significant.
Negative_regulation (inhibition) of Regulation (effect) of prolactin in plasma
5) Confidence 0.43 Published 1985 Journal Neuroendocrinology Section Abstract Doc Link 2931613 Disease Relevance 0 Pain Relevance 0.49
On a second trial but with workload maintained at reference values (222 +/- 9 W), a significant bradycardia was observed with face cooling; furthermore, plasma PRL response to exercise was significantly reduced (to 31% of original response).
Negative_regulation (reduced) of Regulation (response) of PRL in face associated with heart rate under development
6) Confidence 0.43 Published 1989 Journal Eur J Appl Physiol Occup Physiol Section Abstract Doc Link 2527748 Disease Relevance 0.25 Pain Relevance 0.03
PRL responses was blunted in group A (p < 0.001) and significantly decreased in group B (p < 0.05).
Negative_regulation (decreased) of Regulation (responses) of PRL
7) Confidence 0.43 Published 1995 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 8868205 Disease Relevance 0.27 Pain Relevance 0.43
Further, the sympatholytic action of icv-PRL in anesthetized rats prevented the effect on ductal tone of both icv-PRL in conscious rats and of ISOP in anesthetized rats.
Negative_regulation (prevented) of Regulation (effect) of PRL
8) Confidence 0.43 Published 2001 Journal Physiol. Behav. Section Abstract Doc Link 11564459 Disease Relevance 0 Pain Relevance 0.09
Naloxone caused a modest, though significant, attenuation of the PRL surge during nursing. beta-FNA and nor-BNI inhibited suckling-induced PRL release in a dose-related fashion, and at sufficient doses, both antagonists abolished the PRL response.
Negative_regulation (abolished) of Regulation (response) of PRL associated with antagonist and narcan
9) Confidence 0.43 Published 1991 Journal Brain Res. Section Abstract Doc Link 1667901 Disease Relevance 0.06 Pain Relevance 0.56
Prior intracerebroventricular (i.c.v.) infusion of the 5-HT(1A) antagonists WAY-100635 and LY-206130 inhibited PRL and ACTH responses to i.c.v. infusion of 8-OH-DPAT, 5-HT as well as to 5-HTP administered systemically in combination with the 5-HT reuptake inhibitor fluoxetine (Flx).
Negative_regulation (inhibited) of Regulation (responses) of PRL associated with antagonist, intracerebroventricular and fluoxetine
10) Confidence 0.42 Published 2001 Journal Neuroendocrinology Section Abstract Doc Link 11399905 Disease Relevance 0.15 Pain Relevance 0.54
On day 13, ketanserin and pCPA had no effect on serum prolactin levels, but after increasing serotoninergic transmission by injecting fluoxetine and 5-hydroxytryptophan, serum prolactin levels were decreased.
Negative_regulation (decreased) of Neg (no) Regulation (effect) of prolactin associated with fluoxetine
11) Confidence 0.42 Published 1988 Journal J. Endocrinol. Section Abstract Doc Link 2969029 Disease Relevance 0 Pain Relevance 0.25
Contrary to findings with LHRH and LH, repeated injections of a small dose (10 ng) of TRH in the afternoon of proestrus abolished PRL and TSH responses to subsequent injection of the neurohormone.
Negative_regulation (abolished) of Regulation (responses) of PRL
12) Confidence 0.41 Published 1977 Journal Endocrinology Section Abstract Doc Link 192538 Disease Relevance 0 Pain Relevance 0.07
The aim of this study was to examine prolactin (PRL) regulation of preproenkephalin and proopiomelanocortin (POMC) gene expression in the hypothalamus during lactation.
Spec (examine) Negative_regulation (examine) of Spec (examine) Regulation (regulation) of prolactin in hypothalamus
13) Confidence 0.41 Published 2003 Journal Endocrine Section Abstract Doc Link 12668876 Disease Relevance 0.14 Pain Relevance 0
The aim of this study was to examine prolactin (PRL) regulation of preproenkephalin and proopiomelanocortin (POMC) gene expression in the hypothalamus during lactation.
Spec (examine) Negative_regulation (examine) of Spec (examine) Regulation (regulation) of PRL in hypothalamus
14) Confidence 0.41 Published 2003 Journal Endocrine Section Abstract Doc Link 12668876 Disease Relevance 0.14 Pain Relevance 0
NAL blocked the GH rise and depressed TSH levels, but did not significantly inhibit the PRL or beta-END-LI response.
Negative_regulation (inhibit) of Regulation (response) of PRL associated with narcan
15) Confidence 0.41 Published 1984 Journal Endocrinology Section Abstract Doc Link 6323136 Disease Relevance 0 Pain Relevance 0.60
Tolerance in some endocrine systems appears to be quite long-lasting, as CS, TSH and PRL responses to METH challenge were still decreased 3 weeks after withdrawal from the ID regimen.
Negative_regulation (decreased) of Regulation (responses) of PRL in endocrine systems associated with tolerance, methadone and withdrawal
16) Confidence 0.40 Published 1985 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 4040169 Disease Relevance 0 Pain Relevance 0.75
On the basis of these data and the known suppressive action of PRL on the corticosterone response to stress in the rat, we suggest that the suppressive action of beta-End on cortisol secretion in stressed sheep could be caused by the action of PRL.
Negative_regulation (suppressive) of Regulation (response) of PRL associated with stress
17) Confidence 0.39 Published 1993 Journal Neuroendocrinology Section Abstract Doc Link 8479608 Disease Relevance 0.54 Pain Relevance 0.10
Prolactin values were reduced in all cases, becoming either normalized or suppressed in 12.
Negative_regulation (reduced) of Regulation (values) of Prolactin
18) Confidence 0.39 Published 1993 Journal Acta Endocrinol. Section Abstract Doc Link 8098891 Disease Relevance 0.66 Pain Relevance 0.17
Prolactin values were reduced in all cases, becoming either normalized or suppressed in 12.
Negative_regulation (suppressed) of Regulation (values) of Prolactin
19) Confidence 0.39 Published 1993 Journal Acta Endocrinol. Section Abstract Doc Link 8098891 Disease Relevance 0.69 Pain Relevance 0.18
This conclusion is based on the following findings: 1) The minimum effective IV dose of clonidine or UK 14304 was four times larger for activation of PRL than GH secretion and had already manifest extracentral effects (elevation of arterial BP). 2) Subcutaneous injection of UK 14304 (220 micrograms/kg) elevated plasma GH but not PRL levels indicating that an effective activation of the central alpha 2 receptors does not stimulate PRL release. 3) Peripherally acting alpha 2 agonists (p-aminoclonidine, oxymetazoline) had no effect on GH secretion but stimulated PRL release in a manner identical with the effect of clonidine or UK 14304. 4) The peripherally acting alpha 2 antagonist DG-5128 blocked only the PRL secretory response to UK 14304 whereas the peripherally and centrally active yohimbine blocked the PRL and GH responses.
Negative_regulation (blocked) of Regulation (responses) of PRL in plasma associated with antagonist, agonist and clonidine
20) Confidence 0.34 Published 1989 Journal Brain Res. Bull. Section Abstract Doc Link 2575439 Disease Relevance 0 Pain Relevance 0.43

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