INT138051

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Context Info
Confidence 0.57
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.84
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SRC) cytoplasm (SRC) cytosol (SRC)
signal transduction (SRC) cell adhesion (SRC) nucleus (SRC)
Anatomy Link Frequency
microglia 2
SRC (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropathic pain 2 96.68 Very High Very High Very High
intrathecal 1 69.16 Quite High
Dorsal horn 1 65.32 Quite High
Peripheral nerve injury 1 61.48 Quite High
Spinal cord 1 58.16 Quite High
antagonist 10 55.32 Quite High
opiate 9 54.88 Quite High
long-term potentiation 1 54.84 Quite High
qutenza 3 50.00 Quite Low
Opioid 5 49.08 Quite Low
Disease Link Frequency Relevance Heat
Hypersensitivity 6 98.52 Very High Very High Very High
Neuropathic Pain 2 96.68 Very High Very High Very High
Multiple Myeloma 1 77.28 Quite High
Nervous System Injury 4 75.28 Quite High
Appetite Loss 1 38.68 Quite Low
Thrombocytopenia 1 37.56 Quite Low
Hyperglycemia 1 36.84 Quite Low
Anaemia 1 36.24 Quite Low
Pressure And Volume Under Development 1 35.92 Quite Low
Vomiting 1 35.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The activation of Janus-activated kinase 1 and c-Src, implicated in STAT3 activation, was also inhibited by the vanilloid, with no effect on extracellular signal-regulated kinase 1/2 activation.
Negative_regulation (inhibited) of Positive_regulation (activation) of c-Src
1) Confidence 0.57 Published 2007 Journal Clin. Cancer Res. Section Body Doc Link 17505005 Disease Relevance 0.08 Pain Relevance 0
Therefore, preventing the activation of the Src/ERK signaling cascade in microglia might provide a fruitful strategy for treating neuropathic pain.
Negative_regulation (preventing) of Positive_regulation (activation) of Src in microglia associated with neuropathic pain
2) Confidence 0.42 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16928856 Disease Relevance 0.76 Pain Relevance 0.25
The synergistic mechanism involves MNTX activation of tyrosine phosphatase activity with consequent inhibition of VEGF-induced Src activation.
Negative_regulation (inhibition) of Positive_regulation (activation) of Src
3) Confidence 0.29 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0 Pain Relevance 0.08

General Comments

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