INT138125

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Context Info
Confidence 0.49
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.04
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (MMP14)
Anatomy Link Frequency
skin 1
osteoclast 1
nucleus pulposus 1
MMP14 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 16 100.00 Very High Very High Very High
palliative 45 93.56 High High
backache 1 64.56 Quite High
TRP channel 1 61.92 Quite High
cytokine 2 45.36 Quite Low
Pain 10 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Analgesic 3 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Fibrositis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Prostate Cancer 70 99.88 Very High Very High Very High
Cancer 75 99.84 Very High Very High Very High
Metastasis 70 99.64 Very High Very High Very High
Hepatocellular Cancer 58 90.64 High High
Injury 33 87.12 High High
Osteolysis 8 86.68 High High
Necrosis 1 84.16 Quite High
Malignant Neoplastic Disease 2 77.48 Quite High
Aggression 2 70.32 Quite High
Lifespan 8 69.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We demonstrate that in nucleus pulposus cells, the p38 and JNK pathways regulate induction of MMP-1 and -3; p38, JNK, and NF-kappaB regulate the induction of MMP-13; and ERK regulates the up-regulation of MT1-MMP mRNA in response to TNFalpha.
Positive_regulation (up-regulation) of MT1-MMP in nucleus pulposus
1) Confidence 0.49 Published 2006 Journal Matrix Biol. Section Abstract Doc Link 16934445 Disease Relevance 0.29 Pain Relevance 0.06
The alteration of endostatin (a potent angiogenesis inhibitor) and MT1-MMP (an activator of MMP2) was minor, which indicated that elevated tumor VEGF and increased MMP2 activity were not directly due to endostatin and MT1-MMP, whose detailed molecular mechanism remains to be elucidated.
Positive_regulation (activator) of MT1-MMP associated with cancer
2) Confidence 0.49 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2976755 Disease Relevance 1.13 Pain Relevance 0.38
We conducted a series of studies to assess the contribution of prostate cancer cell–derived mt1-mmp to bone metastasis.
Positive_regulation (derived) of mt1-mmp associated with prostate cancer and metastasis
3) Confidence 0.14 Published 2008 Journal Current Oncology Section Body Doc Link PMC2528310 Disease Relevance 1.42 Pain Relevance 0
We further showed that mt1-mmp upregulation in cancer cells resulted in the release of one or more factors that promoted osteoclast differentiation in vitro.
Positive_regulation (upregulation) of mt1-mmp in osteoclast associated with cancer
4) Confidence 0.14 Published 2008 Journal Current Oncology Section Body Doc Link PMC2528310 Disease Relevance 1.05 Pain Relevance 0
For wIRA with appropriate therapeutic irradiances and doses it could not only be demonstrated, that it is harmless for human skin (no induction of matrix metalloproteinase 1) [13], [24], but that it has cell protective effects against the damages caused by UV radiation [23], [24], [25].
Positive_regulation (induction) of matrix metalloproteinase 1 in skin associated with metalloproteinase
5) Confidence 0.09 Published 2007 Journal GMS Krankenhaushygiene Interdisziplinar Section Body Doc Link PMC2831244 Disease Relevance 0.16 Pain Relevance 0.08

General Comments

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