INT138216

Context Info Confidence 0.37 First Reported 2003 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 13 Total Number 14 Disease Relevance 9.66 Pain Relevance 4.55

nucleus (PER1) protein binding transcription factor activity (PER1) cytoplasm (PER1) signal transducer activity (PER1)

Anatomy Link Frequency nerve 1 median nerve 1 autonomic 1 PER1 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 33 100.00 transcutaneous nerve stimulation 26 99.98 Autonomic response 2 99.98 Pain 79 99.56 addiction 20 96.36 depression 52 95.52 tricyclic antidepressant 6 87.16 cytokine 9 85.28 Lasting pain 1 80.20 Acupuncture 110 79.84

Disease Link Frequency Relevance Heat Rhinitis 51 100.00 INFLAMMATION 45 100.00 Weight Loss 43 100.00 Psychosis 37 100.00 Sleep Disorders 21 100.00 Dengue 2 99.98 Stress 26 99.76 Pain 75 99.56 Asthma 89 99.40 Injury 35 99.38

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

TENS was administered over the right median nerve for 10 min at 100 pulses per second (pps) and an intensity which elicited mild tingling in the hand.

Negative_regulation (administered) of pulses per second in median nerve associated with transcutaneous nerve stimulation

1) Confidence 0.37 Published 2006 Journal Clin Physiol Funct Imaging Section Abstract Doc Link 16939510 Disease Relevance 0.35 Pain Relevance 1.17

Of note, community size was also found to be significantly associated with malaria persistence due to both malaria species in jungle regions but not in coast and mountain regions, which is in agreement with dengue persistence in Perú [58].

Negative_regulation (persistence) of Per associated with malaria and dengue

2) Confidence 0.35 Published 2009 Journal Malar J Section Body Doc Link PMC2714521 Disease Relevance 0.81 Pain Relevance 0

An interesting finding is that Per1 and Per2 are upregulated in the morning in hSkM (Figure 2), and downregulated in the morning in mSkM (Figure 3b).

Negative_regulation (downregulated) of Per1

3) Confidence 0.34 Published 2003 Journal Genome Biol Section Body Doc Link PMC328450 Disease Relevance 0 Pain Relevance 0

As with previous studies, it is not possible to say how much of the apparent failure of these tools is due to the failure of the tool per se, or to failures of the patient monitoring processes within the study.

Negative_regulation (failure) of per se

4) Confidence 0.31 Published 2003 Journal Crit Care Section Body Doc Link PMC270726 Disease Relevance 0.38 Pain Relevance 0.04

This study compared TENS delivered at 3 pulses per second (pps) and 80 pps on blunt pressure pain in human participants when TENS intensity was standardized at a strong nonpainful level.

Negative_regulation (delivered) of pulses per second associated with pain and transcutaneous nerve stimulation

5) Confidence 0.26 Published 2010 Journal J Pain Section Abstract Doc Link 19665936 Disease Relevance 0.50 Pain Relevance 1.40

Reduction of drug driving and drug related trauma likely require policies which reduce drug use per se, and are not limited to harm reduction measures alone.

Negative_regulation (reduce) of per se associated with injury

6) Confidence 0.11 Published 2008 Journal Subst Abuse Treat Prev Policy Section Abstract Doc Link PMC2396610 Disease Relevance 0.60 Pain Relevance 0.21

Investigating the relative contribution of changes in BMI, physical activity, and diet will provide evidence of whether the underlying mechanism for improvement in asthma control is related to weight loss per se or not.

Spec (whether) Negative_regulation (loss) of per se associated with asthma, weight loss and obesity

7) Confidence 0.06 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2860346 Disease Relevance 1.42 Pain Relevance 0.07

Treatment for the schizoaffective patients in contrast should focus additionally on the reduction of psychosis per se in addition to the reduction of negative symptoms.

Negative_regulation (reduction) of per se associated with psychosis

8) Confidence 0.04 Published 2007 Journal Ann Gen Psychiatry Section Body Doc Link PMC1845151 Disease Relevance 1.56 Pain Relevance 0.03

Just before randomisation, participants will be informed that they will be assigned to one of three groups, including two that have the potential to reduce PER symptoms and a waitlist for treatment.

Negative_regulation (reduce) of PER associated with rhinitis

9) Confidence 0.04 Published 2009 Journal Trials Section Body Doc Link PMC2715403 Disease Relevance 0.10 Pain Relevance 0.10

For all other forms of intervention, however, and for all attempts to diminish grief per se, no consistent pattern of treatment benefit has been established across well-designed experimental studies.

Negative_regulation (diminish) of per se

10) Confidence 0.04 Published 2004 Journal BMC Palliat Care Section Body Doc Link PMC503393 Disease Relevance 0.10 Pain Relevance 0.05

Sleep deprivation per se is a stress condition, which causes the inappropriate activation of the hypothalamic?

Negative_regulation (deprivation) of per se associated with stress and sleep disorders

11) Confidence 0.02 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2999703 Disease Relevance 1.78 Pain Relevance 0.22

Low level production of NO by the constitutive forms of NOS may relieve pain by increasing vasodilatation and improving circulation as well as by reducing nerve irritation and inflammation per se.

Negative_regulation (reducing) of per se in nerve associated with pain, inflammation and increased venous pressure under development

12) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582806 Disease Relevance 1.74 Pain Relevance 1.21

No differences were detected demonstrating that the decrease in the enzymatic activity of the Ile170Val TPI variant is based on reduced enzymatic activity per se (data not shown).

Negative_regulation (reduced) of per se

13) Confidence 0.01 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762313 Disease Relevance 0.11 Pain Relevance 0

As is mentioned before, although the top-down control of physiological responses are disrupted, autonomic responses per se are not impaired in people with high alexithymia [10], [14].

Negative_regulation (impaired) of per se in autonomic associated with autonomic response

14) Confidence 0.00 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2577735 Disease Relevance 0.22 Pain Relevance 0.05

General Comments

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