INT138466

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|-
 
|-
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| First Reported
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| First Reported
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 2006
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2006|2006]]
 
|-
 
|-
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Last Reported
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Last Reported
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 2010
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2010|2010]]
 
|-
 
|-
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Negated
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| Negated
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style=filled,
 
style=filled,
 
fillcolor=yellow,
 
fillcolor=yellow,
URL=Regulation
+
URL="http://wikipaints.org/vhosts/wikipaints/mediawiki-1.19.1/index.php?title=E:Regulation"
 
];
 
];
 
node2
 
node2
Line 54: Line 54:
 
fillcolor=green,
 
fillcolor=green,
 
label="Gene\nexpression",
 
label="Gene\nexpression",
URL=Gene_expression
+
URL="http://wikipaints.org/vhosts/wikipaints/mediawiki-1.19.1/index.php?title=E:Gene_expression"
 
];
 
];
 
node3
 
node3
Line 62: Line 62:
 
fontcolor=white,
 
fontcolor=white,
 
label="Ryr2",
 
label="Ryr2",
URL="Ryr2"
+
URL="http://wikipaints.org/vhosts/wikipaints/mediawiki-1.19.1/index.php?title=G:689560"
 
];
 
];
 
subgraph cluster_0 {
 
subgraph cluster_0 {
Line 82: Line 82:
 
{| cellspacing=5 cellpadding=2
 
{| cellspacing=5 cellpadding=2
 
|-
 
|-
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[protein complex]] ([[Ryr2]])
+
| style="color: black; background:#F7F7CD; border: 1px solid lightgray; white-space:wrap;"| [[GOS:protein complex|protein complex]] ([[G:689560|Ryr2]])
 
|-
 
|-
 
|}
 
|}
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{| cellpadding=3 cellspacing=0  
 
{| cellpadding=3 cellspacing=0  
 
|-
 
|-
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Anatomy Mention
+
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"| Anatomy Link
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;" align="center"| Frequency
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;" align="center"| Frequency
 
|-
 
|-
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| [[anat:1543|cardiomyocytes]]
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"| [[A:cardiomyocytes|cardiomyocytes]]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"|2
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"|2
 
|-
 
|-
Line 109: Line 109:
 
{| cellspacing=1 cellpadding=5 align=center
 
{| cellspacing=1 cellpadding=5 align=center
 
|-
 
|-
! style="color: black; background:#AAFCFB; white-space:wrap;"| Pain Term
+
! style="color: black; background:#AAFCFB; white-space:wrap;"| Pain Link
 
! style="color: black; background:#AAFCFB; white-space:wrap;"| Frequency
 
! style="color: black; background:#AAFCFB; white-space:wrap;"| Frequency
! style="color: black; background:#AAFCFB; white-space:wrap;"| Confidence
+
! style="color: black; background:#AAFCFB; white-space:wrap;"| Relevance
 
! style="color: black; background:#AAFCFB; white-space:wrap;"| Heat
 
! style="color: black; background:#AAFCFB; white-space:wrap;"| Heat
 
|-
 
|-
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[antiarrhythmic agent]]
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:antiarrhythmic agent|antiarrhythmic agent]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 3
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 3
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 88.72
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 88.72
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|High}} {{#icon: chilli.png|High}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|High}} {{#icon: chilli.png|High}}
 
|-
 
|-
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[tolerance]]
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:tolerance|tolerance]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 2
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 2
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 79.76
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 79.76
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}}
 
|-
 
|-
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[lidocaine]]
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:lidocaine|lidocaine]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 2
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 2
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 72.64
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 72.64
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}}
 
|-
 
|-
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[ischemia]]
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:ischemia|ischemia]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 3
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 3
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 67.28
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 67.28
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}}
 
|-
 
|-
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Bioavailability]]
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:Bioavailability|Bioavailability]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 1
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 1
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 62.68
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 62.68
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}}
 
|-
 
|-
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[imagery]]
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:imagery|imagery]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 9
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 9
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 57.52
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 57.52
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}}
 
|-
 
|-
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[tetrodotoxin]]
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:Calcium channel|Calcium channel]]
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 1
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 2
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 5.00
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 5.00
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
 
|-
 
|-
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[ketamine]]
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:tetrodotoxin|tetrodotoxin]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 1
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 1
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 5.00
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 5.00
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
 
|-
 
|-
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[fibrosis]]
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:ketamine|ketamine]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 1
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 1
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 5.00
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 5.00
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
 
|-
 
|-
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[depression]]
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[P:fibrosis|fibrosis]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 1
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 1
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 5.00
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 5.00
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{| cellspacing=1 cellpadding=5 align=center
 
{| cellspacing=1 cellpadding=5 align=center
 
|-
 
|-
! style="color: black; background:#AAFCFB; white-space:wrap;"| Disease Term
+
! style="color: black; background:#AAFCFB; white-space:wrap;"| Disease Link
 
! style="color: black; background:#AAFCFB; white-space:wrap;"| Frequency
 
! style="color: black; background:#AAFCFB; white-space:wrap;"| Frequency
! style="color: black; background:#AAFCFB; white-space:wrap;"| Confidence
+
! style="color: black; background:#AAFCFB; white-space:wrap;"| Relevance
 
! style="color: black; background:#AAFCFB; white-space:wrap;"| Heat
 
! style="color: black; background:#AAFCFB; white-space:wrap;"| Heat
 
|-
 
|-
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Hypoxia]]
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[D:Hypoxia|Hypoxia]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 52
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 52
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 99.84
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 99.84
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
|-
 
|-
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Hypertrophy]]
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[D:Hypertrophy|Hypertrophy]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 80
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 80
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 98.80
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 98.80
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
|-
 
|-
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Ventricular Tachycardia]]
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[D:Ventricular Tachycardia|Ventricular Tachycardia]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 1
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 1
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 97.68
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 97.68
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}} {{#icon: chilli.png|Very High}}
 
|-
 
|-
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Malignant Neoplastic Disease]]
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[D:Malignant Neoplastic Disease|Malignant Neoplastic Disease]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 1
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 1
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 81.68
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 81.68
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}}
 
|-
 
|-
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Cv Unclassified Under Development]]
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[D:Cv Unclassified Under Development|Cv Unclassified Under Development]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 8
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 8
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 67.28
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 67.28
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}}
 
|-
 
|-
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Apoptosis]]
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[D:Apoptosis|Apoptosis]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 25
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 25
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 56.72
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 56.72
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: chilli.png|Quite High}}
 
|-
 
|-
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Myocardial Infarction]]
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[D:Myocardial Infarction|Myocardial Infarction]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 32
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 32
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 39.36
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 39.36
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Quite Low}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Quite Low}}
 
|-
 
|-
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Lymphatic System Cancer]]
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[D:Lymphatic System Cancer|Lymphatic System Cancer]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 1
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 1
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 23.12
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 23.12
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Low}} {{#icon: cold.png|Low}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Low}} {{#icon: cold.png|Low}}
 
|-
 
|-
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[B-cell Acute Lymphoblastic Leukemia]]
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[D:B-cell Acute Lymphoblastic Leukemia|B-cell Acute Lymphoblastic Leukemia]]
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 1
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 1
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 22.76
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 22.76
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Low}} {{#icon: cold.png|Low}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Low}} {{#icon: cold.png|Low}}
 
|-
 
|-
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[Fibrosis]]
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| [[D:Injury|Injury]]
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 1
+
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 16
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 5.00
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| 5.00
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
 
| style="background:#E0FFFF; border: 1px solid white; white-space:wrap;"| {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}} {{#icon: cold.png|Very Low}}
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{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
|  <span style="color:#000080">'''Regulation'''</span> (<span style="color:#000080">undergoes</span>) of <span style="color:#000080">'''Gene_expression'''</span> (<span style="color:#000080">coupling</span>) of <span style="color:#800000">'''RyR'''</span> associated with <span style="color:#FF0000">'''hypertrophy'''</span>
+
[[E:Regulation|<span style="color:#000080">'''Regulation'''</span>]] (<span style="color:#000080">undergoes</span>) of [[E:Gene_expression|<span style="color:#000080">'''Gene_expression'''</span>]] (<span style="color:#000080">coupling</span>) of [[G:689560|<span style="color:#800000">'''RyR'''</span>]] associated with <span style="color:#FF0000">'''hypertrophy'''</span>
 
|-
 
|-
 
|}
 
|}
Line 260: Line 260:
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.28
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.28
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 2007
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2007|2007]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:PLoS Biology|PLoS Biology]]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:PLoS Biology|PLoS Biology]]
Line 280: Line 280:
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
|  Neg (not) <span style="color:#000080">'''Regulation'''</span> (<span style="color:#000080">altered</span>) of <span style="color:#000080">'''Gene_expression'''</span> (<span style="color:#000080">expressions</span>) of <span style="color:#800000">'''RyR'''</span> in <span style="color:#808000">cardiomyocytes</span> associated with <span style="color:#FF0000">'''hypoxia'''</span>
+
|  Neg (not) [[E:Regulation|<span style="color:#000080">'''Regulation'''</span>]] (<span style="color:#000080">altered</span>) of [[E:Gene_expression|<span style="color:#000080">'''Gene_expression'''</span>]] (<span style="color:#000080">expressions</span>) of [[G:689560|<span style="color:#800000">'''RyR'''</span>]] in [[A:cardiomyocytes|<span style="color:#808000">cardiomyocytes</span>]] associated with <span style="color:#FF0000">'''hypoxia'''</span>
 
|-
 
|-
 
|}
 
|}
Line 291: Line 291:
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.27
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.27
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 2010
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2010|2010]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:Yonsei Medical Journal|Yonsei Medical Journal]]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:Yonsei Medical Journal|Yonsei Medical Journal]]
Line 311: Line 311:
 
{| cellpadding=4 cellspacing=2  
 
{| cellpadding=4 cellspacing=2  
 
|-
 
|-
|  <span style="color:#000080">'''Regulation'''</span> (<span style="color:#000080">abnormal</span>) of <span style="color:#000080">'''Gene_expression'''</span> (<span style="color:#000080">expression</span>) of <span style="color:#800000">'''ryanodine receptor type 2'''</span> associated with <span style="color:#FF0000">'''ventricular tachycardia'''</span>
+
[[E:Regulation|<span style="color:#000080">'''Regulation'''</span>]] (<span style="color:#000080">abnormal</span>) of [[E:Gene_expression|<span style="color:#000080">'''Gene_expression'''</span>]] (<span style="color:#000080">expression</span>) of [[G:689560|<span style="color:#800000">'''ryanodine receptor type 2'''</span>]] associated with <span style="color:#FF0000">'''ventricular tachycardia'''</span>
 
|-
 
|-
 
|}
 
|}
Line 322: Line 322:
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.11
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 0.11
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Published
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| 2006
+
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[Y:2006|2006]]
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 
! style="color: black; background:#AAFCFB; border: 1px solid lightgray; white-space:nowrap;"|    Journal
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:Cardiovasc Drug Rev|Cardiovasc Drug Rev]]
 
| style="color: black; background:#F1FEFE; border: 1px solid lightgray; white-space:nowrap;"  align="center"| [[J:Cardiovasc Drug Rev|Cardiovasc Drug Rev]]

Latest revision as of 13:55, 20 September 2012

Context Info
Confidence 0.28
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.62
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex (Ryr2)
Anatomy Link Frequency
cardiomyocytes 2
Ryr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antiarrhythmic agent 3 88.72 High High
tolerance 2 79.76 Quite High
lidocaine 2 72.64 Quite High
ischemia 3 67.28 Quite High
Bioavailability 1 62.68 Quite High
imagery 9 57.52 Quite High
Calcium channel 2 5.00 Very Low Very Low Very Low
tetrodotoxin 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 52 99.84 Very High Very High Very High
Hypertrophy 80 98.80 Very High Very High Very High
Ventricular Tachycardia 1 97.68 Very High Very High Very High
Malignant Neoplastic Disease 1 81.68 Quite High
Cv Unclassified Under Development 8 67.28 Quite High
Apoptosis 25 56.72 Quite High
Myocardial Infarction 32 39.36 Quite Low
Lymphatic System Cancer 1 23.12 Low Low
B-cell Acute Lymphoblastic Leukemia 1 22.76 Low Low
Injury 16 5.00 Very Low Very Low Very Low

[edit] Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, our data provide unequivocal evidence that LCC-RyR coupling undergoes a progressive failure during hypertrophy.
Regulation (undergoes) of Gene_expression (coupling) of RyR associated with hypertrophy
1) Confidence 0.28 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1764437 Disease Relevance 0.75 Pain Relevance 0.07
In addition, phospholamban (PLB) and ryanodine receptor (RyR) expressions were not altered in hypoxia-reoxygenated cardiomyocytes treated with thiopental.
Neg (not) Regulation (altered) of Gene_expression (expressions) of RyR in cardiomyocytes associated with hypoxia
2) Confidence 0.27 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824862 Disease Relevance 0.62 Pain Relevance 0
The abnormal expression of the ryanodine receptor type 2 (RyR2) and of FKBP12.6 is reduced by CPU80617 during its ventricular tachyarrhythmia-suppressing action.
Regulation (abnormal) of Gene_expression (expression) of ryanodine receptor type 2 associated with ventricular tachycardia
3) Confidence 0.11 Published 2006 Journal Cardiovasc Drug Rev Section Abstract Doc Link 16961724 Disease Relevance 0.25 Pain Relevance 0.32

[edit] General Comments

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