INT138548

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Context Info
Confidence 0.41
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.85
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Adrb2) plasma membrane (Adrb2) nucleus (Adrb2)
cytoplasm (Adrb2) signal transducer activity (Adrb2)
Anatomy Link Frequency
muscle 2
Adrb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
interstitial cystitis 10 98.04 Very High Very High Very High
tricyclic antidepressant 5 97.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Overactive Bladder 1 99.68 Very High Very High Very High
Interstitial Cystitis 10 98.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, these results suggest that the Arg16Gly polymorphism of ADRB2 is related to down-regulation of ADRB2 expression in the detrusor muscle, so that the response of IC to tricyclic antidepressant therapy depends on the Arg16Gly polymorphism.
Negative_regulation (down-regulation) of Gene_expression (expression) of ADRB2 in muscle associated with overactive bladder, tricyclic antidepressant and interstitial cystitis
1) Confidence 0.41 Published 2006 Journal Biomed. Res. Section Abstract Doc Link 16971769 Disease Relevance 0.85 Pain Relevance 0.96

General Comments

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