INT138548

Context Info Confidence 0.41 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.85 Pain Relevance 0.96

endosome (Adrb2) plasma membrane (Adrb2) nucleus (Adrb2) cytoplasm (Adrb2) signal transducer activity (Adrb2)

Anatomy Link Frequency muscle 2 Adrb2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat interstitial cystitis 10 98.04 tricyclic antidepressant 5 97.80

Disease Link Frequency Relevance Heat Overactive Bladder 1 99.68 Interstitial Cystitis 10 98.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Therefore, these results suggest that the Arg16Gly polymorphism of ADRB2 is related to down-regulation of ADRB2 expression in the detrusor muscle, so that the response of IC to tricyclic antidepressant therapy depends on the Arg16Gly polymorphism.

Negative_regulation (down-regulation) of Gene_expression (expression) of ADRB2 in muscle associated with overactive bladder, tricyclic antidepressant and interstitial cystitis

1) Confidence 0.41 Published 2006 Journal Biomed. Res. Section Abstract Doc Link 16971769 Disease Relevance 0.85 Pain Relevance 0.96

General Comments

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