INT138606

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Context Info
Confidence 0.12
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.54
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (F2) extracellular space (F2) extracellular region (F2)
plasma membrane (F2)
Anatomy Link Frequency
hepatocyte 2
F2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Leflunomide 8 98.30 Very High Very High Very High
Paracetamol 8 92.52 High High
Calcium channel 1 23.24 Low Low
Dismenorea 1 19.12 Low Low
Inflammation 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
cOX1 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 5 99.34 Very High Very High Very High
Death 3 93.28 High High
Apoptosis 1 82.24 Quite High
Stress 1 39.68 Quite Low
Disease 1 31.44 Quite Low
Dysmenorrhea 1 19.12 Low Low
Pre-term Labor 1 16.52 Low Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Y-27632 decreased both basal and thrombin induced contractility.
Negative_regulation (decreased) of Positive_regulation (induced) of thrombin
1) Confidence 0.12 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2645409 Disease Relevance 0 Pain Relevance 0
In conclusion, these findings are consistent with our hypothesis that leflunomide protects from protoxicant-induced hepatocyte injury by inhibiting JNK signaling and preventing mPT induction.
Negative_regulation (preventing) of Positive_regulation (induction) of mPT in hepatocyte associated with injury and leflunomide
2) Confidence 0.02 Published 2006 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 16979204 Disease Relevance 0.54 Pain Relevance 0.74

General Comments

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