INT138714

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Context Info
Confidence 0.18
First Reported 2006
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.39
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Polg) aging (Polg)
Anatomy Link Frequency
Poly 1
Polg (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 3 49.36 Quite Low
Migraine 1 34.88 Quite Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 4 89.60 High High
Aging 2 62.32 Quite High
Lymphatic System Cancer 1 52.28 Quite High
Female Infertility 1 50.52 Quite High
Telangiectasia 5 46.48 Quite Low
Neurological Disease 1 37.36 Quite Low
Dna Damage 1 36.56 Quite Low
Headache 1 34.88 Quite Low
Epilepsy 1 34.08 Quite Low
Parkinson's Disease 1 33.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The transcript levels of Polg and Lig3 (solid circles on Figure 2), evaluated by Real Time PCR, were unchanged compared to the levels observed in non-induced (NI) samples; however, at 9 days post induction, the levels of both these transcripts were significantly decreased.
Neg (unchanged) Positive_regulation (unchanged) of Polg
1) Confidence 0.18 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2715231 Disease Relevance 0 Pain Relevance 0
The maintenance of mitochondrial DNA (mtDNA) is critically dependent upon polymerase-gamma (pol-gamma), encoded by the nuclear gene POLG.
Positive_regulation (dependent) of pol-gamma
2) Confidence 0.08 Published 2006 Journal Hum. Mol. Genet. Section Abstract Doc Link 16987890 Disease Relevance 0.23 Pain Relevance 0
Poly(ADP-ribose) polymerase (PARP-1) is a nuclear enzyme which is activated in response to genotoxic insults by binding damaged DNA and attaching polymers of ADP-ribose to nuclear proteins at the expense of its substrate NAD+.
Positive_regulation (activated) of polymerase in Poly
3) Confidence 0.01 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1868035 Disease Relevance 0.17 Pain Relevance 0

General Comments

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