INT138782

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Context Info
Confidence 0.31
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.21
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Lcn2) extracellular space (Lcn2) extracellular region (Lcn2)
Anatomy Mention Frequency
nerve 1
neurons 1
Lcn2 (Rattus norvegicus)
Pain Term Frequency Confidence Heat
Inflammation 2 100.00 Very High Very High Very High
Dorsal horn neuron 6 100.00 Very High Very High Very High
Pain 1 98.60 Very High Very High Very High
Hyperalgesia 3 98.52 Very High Very High Very High
Sciatic nerve 4 96.12 Very High Very High Very High
Spinal cord 4 95.84 Very High Very High Very High
allodynia 1 93.20 High High
peripheral neuropathy 1 89.44 High High
intrathecal 2 88.80 High High
Dorsal horn 1 84.84 Quite High
Disease Term Frequency Confidence Heat
Nociception 1 100.00 Very High Very High Very High
INFLAMMATION 2 100.00 Very High Very High Very High
Poisoning 1 99.58 Very High Very High Very High
Pain 1 98.60 Very High Very High Very High
Cv General 3 Under Development 4 98.56 Very High Very High Very High
Hyperalgesia 3 98.52 Very High Very High Very High
Neuropathic Pain 4 93.20 High High
Acute Renal Failure 2 5.00 Very Low Very Low Very Low
Renal Disease 2 5.00 Very Low Very Low Very Low
Peripheral Neuropathy 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MATERIAL AND METHODS: We measured serum NGAL, urinary NGAL and L-FABP using commercially available kits before and after 2, 4, 12, 24 and 48 hours following PCI in 25 patients.
Negative_regulation (measured) of NGAL
1) Confidence 0.31 Published 2009 Journal Adv Med Sci Section Body Doc Link 19875355 Disease Relevance 0.10 Pain Relevance 0
MATERIAL AND METHODS: We measured serum NGAL, urinary NGAL and L-FABP using commercially available kits before and after 2, 4, 12, 24 and 48 hours following PCI in 25 patients.
Negative_regulation (measured) of NGAL
2) Confidence 0.31 Published 2009 Journal Adv Med Sci Section Body Doc Link 19875355 Disease Relevance 0.10 Pain Relevance 0
Thus, HD intoxication was associated with deregulation of CDK5 and its activator p35 or p25 in nerve tissues.
Negative_regulation (deregulation) of p25 in nerve associated with poisoning
3) Confidence 0.25 Published 2008 Journal Toxicology Section Abstract Doc Link 18423835 Disease Relevance 0.28 Pain Relevance 0.42
We conclude that Cdk5/p35 and Cdk5/p25 complexes in primary sensory and dorsal horn neurons may potentially be involved in nociceptive transmission after inflammation and may be employed in synaptic plasticity underlying pain hypersensitization.
Negative_regulation (employed) of p25 in neurons associated with nociception, pain, inflammation and dorsal horn neuron
4) Confidence 0.19 Published 2007 Journal Pain Section Abstract Doc Link 16996690 Disease Relevance 0.73 Pain Relevance 0.92

General Comments

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