INT138802

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Context Info
Confidence 0.70
First Reported 2006
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 36
Total Number 39
Disease Relevance 18.80
Pain Relevance 7.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (CFTR) ATPase activity (CFTR) plasma membrane (CFTR)
enzyme binding (CFTR) protein complex (CFTR) transmembrane transport (CFTR)
Anatomy Link Frequency
T84 3
epithelial cells 3
HT-29 2
osteoblasts 2
nasal 2
CFTR (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 627 100.00 Very High Very High Very High
agonist 76 99.88 Very High Very High Very High
Chronic pancreatitis 201 99.84 Very High Very High Very High
cytokine 281 99.40 Very High Very High Very High
sodium channel 121 96.80 Very High Very High Very High
Analgesic 3 91.48 High High
Bioavailability 7 86.24 High High
cINOD 19 83.60 Quite High
depression 2 82.80 Quite High
backache 2 81.96 Quite High
Disease Link Frequency Relevance Heat
Cystic Fibrosis 624 100.00 Very High Very High Very High
Targeted Disruption 100 99.88 Very High Very High Very High
Pancreatitis 306 99.84 Very High Very High Very High
Diarrhoea 109 99.54 Very High Very High Very High
Syndrome 11 99.32 Very High Very High Very High
Epstein-barr Virus 36 99.04 Very High Very High Very High
Rhinitis 39 99.00 Very High Very High Very High
Intestinal Obstruction 4 98.96 Very High Very High Very High
Exocrine Pancreatic Insufficiency 61 98.68 Very High Very High Very High
Nasal Polyps 19 98.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CFTR is also expressed in endothelial cells where it functions as a cyclic nucleotide-regulated chloride channel [66].
Gene_expression (expressed) of CFTR in endothelial cells
1) Confidence 0.70 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC1995617 Disease Relevance 0.07 Pain Relevance 0.04
It is noteworthy that CFTR is expressed in vascular smooth muscle cells and activation of CFTR chloride channels regulates contraction and relaxation of smooth muscle cells; disruption of the CFTR gene prevents cAMP-dependent vasorelaxation in experimental studies [65].
Gene_expression (expressed) of CFTR in smooth muscle cells
2) Confidence 0.70 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC1995617 Disease Relevance 0.05 Pain Relevance 0.03
Patch-clamp recordings were performed in two lines of human airway epithelial cells: IB3-8-3-7 cells, which express wild-type CFTR; and IB3-1 cells, which express the variant CFTR with deletion of phenylalanine 580 (DeltaF580CFTR).
Gene_expression (express) of CFTR in IB3-1
3) Confidence 0.68 Published 2008 Journal Eur. Respir. J. Section Abstract Doc Link 18385167 Disease Relevance 0.54 Pain Relevance 0.38
Acute pancreatitis in association with Campylobacter jejuni-associated diarrhea in a 15-year-old with CFTR mutations: is there a link?
Gene_expression (mutations) of CFTR associated with diarrhoea and pancreatitis
4) Confidence 0.65 Published 2006 Journal JOP Section Title Doc Link 16998246 Disease Relevance 0.67 Pain Relevance 0.12
Although it is well known that chronic pancreatitis is predisposed by heterozygosity for CFTR mutations, little is known about the combination of CFTR mutations with PRSS1 or SPINK1 mutations.
Gene_expression (mutations) of CFTR associated with chronic pancreatitis
5) Confidence 0.64 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2970583 Disease Relevance 0.48 Pain Relevance 0.10
However, P2X agonists, the CFTR activator, and NO-producing drugs did not have a beneficial effect on nasal polyps in situ.



Gene_expression (producing) of CFTR activator in nasal associated with agonist and nasal polyps
6) Confidence 0.62 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671790 Disease Relevance 0.51 Pain Relevance 0.18
Glafenine increased the surface expression of Delta Phe508-CFTR in baby hamster kidney (BHK) cells to approximately 40% of that observed for wild-type CFTR, comparable with the known CFTR corrector 4-cyclohexyloxy-2-{1-[4-(4-methoxybenzensulfonyl)-piperazin-1-yl]-ethyl}-quinazoline (VRT-325).
Gene_expression (expression) of CFTR in kidney
7) Confidence 0.60 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20200141 Disease Relevance 0.26 Pain Relevance 0.30
Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator (CFTR) gene, which encodes a cAMP-activated anion channel expressed in epithelial cells.
Gene_expression (expressed) of CFTR in epithelial cells associated with fibrosis and cystic fibrosis
8) Confidence 0.60 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20200141 Disease Relevance 0.37 Pain Relevance 0.25
G542X is a Class I mutation that results in the complete failure to synthesize functional cystic fibrosis transmembrane conductance regulator (CFTR) and is usually associated with pancreatic insufficiency.
Neg (failure) Gene_expression (synthesize) of CFTR associated with fibrosis, exocrine pancreatic insufficiency and cystic fibrosis
9) Confidence 0.58 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2936924 Disease Relevance 1.39 Pain Relevance 0.35
Patch-clamp recordings were performed in two lines of human airway epithelial cells: IB3-8-3-7 cells, which express wild-type CFTR; and IB3-1 cells, which express the variant CFTR with deletion of phenylalanine 580 (DeltaF580CFTR).
Gene_expression (express) of CFTR in IB3-1
10) Confidence 0.53 Published 2008 Journal Eur. Respir. J. Section Abstract Doc Link 18385167 Disease Relevance 0.49 Pain Relevance 0.38
Partial correction was confirmed by the appearance of mature CFTR in Western blots and by two assays of halide permeability in unpolarized BHK and human embryonic kidney cells.
Gene_expression (appearance) of CFTR in embryonic kidney
11) Confidence 0.52 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20200141 Disease Relevance 0.07 Pain Relevance 0.21
kb YAC [21], express CFTR in an appropriate tissue specific manner and complement the cftr defect in null mice.
Gene_expression (express) of CFTR
12) Confidence 0.48 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.47 Pain Relevance 0.05
Another cytokine, which was found to increase CFTR expression in human bronchial epithelial cells is IL-1 beta and this was associated with an increase in short circuit current in the Ussing chambers [24].
Gene_expression (expression) of CFTR in epithelial cells associated with cytokine
13) Confidence 0.46 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0 Pain Relevance 0.10
Interleukin-4 in contrast to the genetically closely linked interleukin -13 was able to reduce chloride secretion as assessed by 125 I efflux assay by down regulation of CFTR expression in the human intestinal cell line T84 in vitro [93].


Gene_expression (expression) of CFTR in T84
14) Confidence 0.46 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.53 Pain Relevance 0
This cytokine is also a potent upregulator of CFTR protein expression and function in vitro [49,50].
Gene_expression (expression) of CFTR protein associated with cytokine
15) Confidence 0.46 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0 Pain Relevance 0.10
It upregulated CFTR mRNA levels at a dose of 0.25 ng/ml and inhibited CFTR mRNA and protein expression at higher doses [1 ng/ml] in T 84 cells [86].
Gene_expression (expression) of CFTR mRNA
16) Confidence 0.46 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.14 Pain Relevance 0.08
Other cytokines which have been found to reduce CFTR mRNA and intracellular CFTR protein expression and integration in the apical membrane leading to a reduced epithelial secretory response in colonic epithelia [T84 and HT-29] were TGF beta 1 and interleukin-4 [83].
Gene_expression (expression) of CFTR protein in T84 associated with cytokine
17) Confidence 0.46 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.07 Pain Relevance 0.05
Expression of epithelial inducible nitric oxide synthase and NO production was reduced in a human trachea epithelial cell line where CFTR activity was blocked by the over-expression of the CFTR regulatory domain.
Gene_expression (expression) of CFTR in epithelial cell
18) Confidence 0.46 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.44 Pain Relevance 0.22
A dichotomous effect on CFTR expression was noted for Interleukin 1beta.
Gene_expression (expression) of CFTR
19) Confidence 0.46 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.09 Pain Relevance 0.08
In summary, CFTR mutations alone are not sufficient for the pathogenesis of chronic pancreatitis in most patients and further studies are needed to elucidate the role of CFTR in the pathogenesis of chronic pancreatitis.


Gene_expression (mutations) of CFTR associated with chronic pancreatitis
20) Confidence 0.44 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 1.03 Pain Relevance 0.72

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