INT139366

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Context Info
Confidence 0.77
First Reported 2005
Last Reported 2011
Negated 4
Speculated 9
Reported most in Body
Documents 98
Total Number 107
Disease Relevance 67.84
Pain Relevance 3.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PROM1) cilium (PROM1)
Anatomy Link Frequency
stem cell 18
brain 7
stem 4
hematopoietic stem cells 3
neural 2
PROM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nav1.7 3 100.00 Very High Very High Very High
Angina 2 97.04 Very High Very High Very High
Inflammation 217 94.68 High High
chemokine 29 92.32 High High
Pain 10 91.12 High High
Central nervous system 269 89.84 High High
Demyelination 4 89.28 High High
palliative 67 87.48 High High
Spinal cord 58 83.36 Quite High
cytokine 141 81.92 Quite High
Disease Link Frequency Relevance Heat
Muscular Dystrophy 1330 100.00 Very High Very High Very High
Cancer 2121 99.96 Very High Very High Very High
Glioma 1990 99.96 Very High Very High Very High
Disease 466 99.82 Very High Very High Very High
Rheumatoid Arthritis 67 99.74 Very High Very High Very High
Fever 3 99.60 Very High Very High Very High
Brain Tumor 249 99.32 Very High Very High Very High
Adhesions 195 99.32 Very High Very High Very High
Coronary Artery Disease 33 98.52 Very High Very High Very High
Conjunctiva Disease 96 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our small series of cases, Nestin and CD133 expression was associated with a poor prognosis and correlated better with clinical course than the histological grading.
Gene_expression (expression) of CD133
1) Confidence 0.77 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2633002 Disease Relevance 0.68 Pain Relevance 0.09
The results by pairwise comparisons showed that there is a significant difference in survival rates between patients with Nestin and CD133 strong positive expression and any of the other two groups (p < 0.01).
Gene_expression (expression) of CD133
2) Confidence 0.77 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2633002 Disease Relevance 0.51 Pain Relevance 0
While the prognostic significance of the histological diagnosis strongly depends on the experience of the respective neuropathologist, analysis of both available data sets revealed that Nestin and CD133 expression was superior in predicting the patient's survival.
Gene_expression (expression) of CD133 in superior
3) Confidence 0.77 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2633002 Disease Relevance 0.47 Pain Relevance 0.04
Therefore, the purpose of this study is to determine the correlation of Nestin and CD133 expression with the grading of gliomas and their predictive efficiency in clinical outcome of patients.


Gene_expression (expression) of CD133 associated with glioma
4) Confidence 0.77 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2633002 Disease Relevance 0.51 Pain Relevance 0
It has been reported that TSC expressing the markers Nestin and CD133 in a variety of brain tumors [13].
Gene_expression (expressing) of CD133 in brain associated with brain tumor
5) Confidence 0.77 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2633002 Disease Relevance 0.60 Pain Relevance 0
Furthermore, according to the conjoined expression of Nestin/CD133, the patients were categorized into four groups: Nestin-/CD133-, Nestin-/CD133+, Nestin+/CD133-, and Nestin+/CD133+.
Gene_expression (expression) of CD133
6) Confidence 0.77 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2633002 Disease Relevance 0.45 Pain Relevance 0
The association of Nestin and CD133 expression with the 5-year survival rate of patients with gliomas was analyzed using Kaplan-Meier analysis.
Spec (analyzed) Gene_expression (expression) of CD133 associated with glioma
7) Confidence 0.77 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2633002 Disease Relevance 0.66 Pain Relevance 0
CD133 (also named as Prominin) is a cell surface marker expressed on normal human NSC and acutely dissociated brain tumor cells [11].
Gene_expression (expressed) of CD133 in brain associated with brain tumor
8) Confidence 0.77 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2633002 Disease Relevance 0.70 Pain Relevance 0
To evaluate whether a correlation between the expression of Nestin, CD133 and the pathological grades of gliomas could be observed a bi-variate correlation analysis (Pearson correlation coefficients) was done.
Gene_expression (expression) of CD133 associated with glioma
9) Confidence 0.77 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2633002 Disease Relevance 0.78 Pain Relevance 0
The Chi-square value by Mantel-Cox indicated a significant difference among different groups with regard to the expression status of Nestin and CD133 (p < 0.01) (Table 3, Figure 2A and 2B).
Gene_expression (expression) of CD133
10) Confidence 0.77 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2633002 Disease Relevance 0.56 Pain Relevance 0
Prognostic implications of Nestin and CD133 expression in human gliomas
Gene_expression (expression) of CD133 associated with glioma
11) Confidence 0.77 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2633002 Disease Relevance 0.66 Pain Relevance 0
The fraction of tumour cells expressing CD133 (Prominin-1), a marker for both neural stem cells and brain cancer stem cells, is enriched after radiation in gliomas.
Gene_expression (expressing) of Prominin-1 in stem cells associated with cancer, glioma and brain tumor
12) Confidence 0.72 Published 2006 Journal Nature Section Abstract Doc Link 17051156 Disease Relevance 1.24 Pain Relevance 0.09
The fraction of tumour cells expressing CD133 (Prominin-1), a marker for both neural stem cells and brain cancer stem cells, is enriched after radiation in gliomas.
Gene_expression (expressing) of CD133 in stem cells associated with cancer, glioma and brain tumor
13) Confidence 0.72 Published 2006 Journal Nature Section Abstract Doc Link 17051156 Disease Relevance 1.24 Pain Relevance 0.09
In both cell culture and the brains of immunocompromised mice, CD133-expressing glioma cells survive ionizing radiation in increased proportions relative to most tumour cells, which lack CD133.
Gene_expression (expressing) of CD133 in brains associated with cancer and glioma
14) Confidence 0.72 Published 2006 Journal Nature Section Abstract Doc Link 17051156 Disease Relevance 1.40 Pain Relevance 0.08
CD133-expressing tumour cells isolated from both human glioma xenografts and primary patient glioblastoma specimens preferentially activate the DNA damage checkpoint in response to radiation, and repair radiation-induced DNA damage more effectively than CD133-negative tumour cells.
Gene_expression (expressing) of CD133 associated with glioblastoma, cancer and glioma
15) Confidence 0.72 Published 2006 Journal Nature Section Abstract Doc Link 17051156 Disease Relevance 1.60 Pain Relevance 0.07
Furthermore, the Spearman correlations (rs) were 0.89 (p = 0.02) indicating that the expression level of Nestin was positively correlated with that of CD133 significantly.


Gene_expression (expression) of CD133
16) Confidence 0.67 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2633002 Disease Relevance 0.74 Pain Relevance 0
Statistically significant correlations between the percentages of immunostained cells and pathological grades of gliomas were found for Nestin (cp = 0.592, p < 0.01) and CD133 (cp = 0.563, p = 0.01), which means that with higher malignant grades of gliomas, higher protein expression could be found.
Gene_expression (found) of CD133 associated with malignant neoplastic disease and glioma
17) Confidence 0.67 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2633002 Disease Relevance 0.86 Pain Relevance 0
CD133 (also named as Prominin) is a cell surface marker expressed on normal human NSC and acutely dissociated brain tumor cells [11].
Gene_expression (expressed) of Prominin in brain associated with brain tumor
18) Confidence 0.60 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2633002 Disease Relevance 0.70 Pain Relevance 0
Expression of Nestin and CD133 in Human Glioma tissue
Gene_expression (Expression) of CD133 associated with glioma
19) Confidence 0.60 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2633002 Disease Relevance 0.70 Pain Relevance 0
The expression levels of Nestin and CD133 in glioma tissues were analyzed by immunohistochemical staining.
Spec (analyzed) Gene_expression (expression) of CD133 associated with glioma
20) Confidence 0.60 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2633002 Disease Relevance 1.17 Pain Relevance 0

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