INT13952

Context Info Confidence 0.65 First Reported 1986 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 11 Total Number 14 Disease Relevance 6.40 Pain Relevance 2.93

Anatomy Link Frequency NIL 3 pars tuberalis 2 NIL 2 blood 1 hypothalamus 1 Nil (Mus musculus)

Pain Link Frequency Relevance Heat Enkephalin 22 99.92 Clonidine 10 98.86 agonist 68 98.52 fibrosis 11 97.40 cocaine 10 95.76 opiate 1 93.04 Neurotransmitter 28 75.00 Dynorphin 2 75.00 Dopamine 41 73.52 antagonist 119 66.80

Disease Link Frequency Relevance Heat Mycobacterial Infection 692 99.70 Pancreatic Cancer 4 98.44 Cystic Fibrosis 4 97.40 Alcoholic Pancreatitis 4 96.72 Rheumatoid Arthritis 27 86.52 Acquired Immune Deficiency Syndrome Or Hiv Infection 268 80.48 Metaplasia 1 78.16 Hyperplasia 19 76.96 Pleurisy 100 76.08 Pleural Tuberculosis 12 75.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

M allosteric iNOS inhibitor L-NIL, as expected, almost completely inhibited NO release.

Gene_expression (expected) of NIL

1) Confidence 0.65 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0 Pain Relevance 0

The NIL were found in 55 of 164 randomly selected cases, with age-related frequency, in 21 of 30 cases of chronic alcoholic pancreatitis, in 2 of 2 cases of cystic fibrosis, and in 25 of 32 cases of pancreatic carcinoma.

Gene_expression (found) of NIL in NIL associated with fibrosis, pancreatic cancer, cystic fibrosis and alcoholic pancreatitis

2) Confidence 0.59 Published 1994 Journal Pathol. Int. Section Abstract Doc Link 7952149 Disease Relevance 1.17 Pain Relevance 0.16

Although the NIL was found to contain much more immunoreactive OT and AVP than MENK or DYN, under basal conditions the release of MENK was equal to or greater than the release of OT, while the release of DYN approached that of AVP.

Gene_expression (found) of NIL in NIL associated with enkephalin

3) Confidence 0.29 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1682832 Disease Relevance 0 Pain Relevance 0.68

Methionine (Met) enkephalin is detectable in rat hypothalamic and neurointermediate lobe (NIL) tissue extracts using a specific radioimmunoassay.

Gene_expression (detectable) of NIL in NIL associated with enkephalin

4) Confidence 0.16 Published 1990 Journal Brain Res. Section Abstract Doc Link 2364280 Disease Relevance 0 Pain Relevance 0.32

Beta-endorphin was the major form of IR-BE released by the AP and the sole constituent and secretory product of the NIL.

Gene_expression (product) of NIL in NIL

5) Confidence 0.11 Published 1988 Journal Life Sci. Section Abstract Doc Link 2969443 Disease Relevance 0 Pain Relevance 0.39

The NIL only expresses RALDH3 and no expression was found in the pars tuberalis (?

Gene_expression (expresses) of NIL in pars tuberalis

6) Confidence 0.06 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.58 Pain Relevance 0

It is known for many years from the work of Nira Ben-Jonathan and Georges Nagy that the NIL produces PRL releasing factors that appear to be important for the suckling-induced PRL release (627).

Gene_expression (produces) of NIL in NIL

7) Confidence 0.06 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.06

The NIL only expresses RALDH3 and no expression was found in the pars tuberalis (?

Gene_expression (expresses) of NIL in pars tuberalis

8) Confidence 0.06 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.58 Pain Relevance 0

Chronic treatment with the alpha-adrenergic agonist, clonidine (CLON), increased, whereas treatment with EB decreased, IR-BE levels in the AP, NIL and hypothalamus.

Gene_expression (levels) of NIL in hypothalamus associated with agonist and clonidine

9) Confidence 0.04 Published 1986 Journal Peptides Section Abstract Doc Link 2948165 Disease Relevance 0 Pain Relevance 0.64

The test was positive if the TB antigen minus Nil value was ?

Gene_expression (value) of Nil associated with mycobacterial infection

10) Confidence 0.04 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2279134 Disease Relevance 0.88 Pain Relevance 0

responses in blood (p = 0.046) and Nil IFN-?

Gene_expression (responses) of Nil in blood

11) Confidence 0.03 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2279134 Disease Relevance 1.81 Pain Relevance 0

8 IU/ml and PHA (positive control) minus Nil had to be ?

Gene_expression (had) of Nil

12) Confidence 0.03 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2279134 Disease Relevance 0.87 Pain Relevance 0

Still, the Nil IFN-?

Gene_expression (Still) of Nil

13) Confidence 0.03 Published 2008 Journal BMC Infect Dis Section Abstract Doc Link PMC2279134 Disease Relevance 0.51 Pain Relevance 0.03

Chronic treatment with the alpha-adrenergic agonist, clonidine (CLON), increased, whereas treatment with EB decreased, IR-BE levels in the AP, NIL and hypothalamus.

Gene_expression (levels) of NIL in NIL associated with agonist and clonidine

14) Confidence 0.01 Published 1986 Journal Peptides Section Abstract Doc Link 2948165 Disease Relevance 0 Pain Relevance 0.64

General Comments

This test has worked.