INT139625

Context Info Confidence 0.50 First Reported 2005 Last Reported 2010 Negated 2 Speculated 0 Reported most in Body Documents 5 Total Number 8 Disease Relevance 3.59 Pain Relevance 1.32

ATPase activity (Cftr) enzyme binding (Cftr) molecular_function (Cftr) protein complex (Cftr) transmembrane transport (Cftr) cytoplasm (Cftr)

Anatomy Link Frequency lymphocytes 2 biliary tract 2 Cftr (Rattus norvegicus)

Pain Link Frequency Relevance Heat Inflammation 126 99.88 Prostatitis 272 99.60 fibrosis 51 99.56 cytokine 52 88.16 agonist 14 5.00 Central nervous system 8 5.00 Inflammatory response 8 5.00 addiction 7 5.00 adenocard 6 5.00 TRP channel 6 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 134 99.88 Cystic Fibrosis 51 99.84 Prostatitis 272 99.60 Constipation 39 92.92 Benign Prostatic Hypertrophy 12 91.80 Bacterial Infection 92 86.96 Spasticity 2 69.68 Disease 15 56.48 Bacterial Respiratory Disease 12 46.72 Pressure And Volume Under Development 31 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Additionally, western blot experiments showed that there was no difference in CFTR expression between the control (data not shown), loperamide and NAR-treated loperamide-administered group, implying the direct modulation of naringenin on the CFTR function rather than expression.

Neg (no) Regulation (difference) of Gene_expression (expression) of CFTR

1) Confidence 0.50 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2553183 Disease Relevance 0.75 Pain Relevance 0

The expression of CFTR and CAII is up-regulated in human prostatitis

Regulation (regulated) of Gene_expression (expression) of CFTR associated with prostatitis

2) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2998414 Disease Relevance 0.38 Pain Relevance 0.15

Compared to the tissue without inflammation, the expression of CFTR in the prostate glands evident of lymphocytes infiltration (Figure 9B) was much stronger, indicating that the expression of CFTR was up-regulated in human prostatitis.

Regulation (regulated) of Gene_expression (expression) of CFTR in lymphocytes associated with inflammation and prostatitis

3) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2998414 Disease Relevance 0.82 Pain Relevance 0.32

As shown in Figure 3B and 3C, mRNA and protein expression of CFTR and CAII were significantly up-regulated upon stimulation of E.coli-LPS, respectively.

Regulation (regulated) of Gene_expression (expression) of CFTR

4) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2998414 Disease Relevance 0.69 Pain Relevance 0.43

In order to investigate the role of CFTR in prostatitis, we first examined its expression in rat prostate since CFTR expression in the prostate has not been demonstrated in any species other than the human.

Neg (not) Regulation (demonstrated) of Gene_expression (expression) of CFTR associated with prostatitis

5) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2998414 Disease Relevance 0.44 Pain Relevance 0.20

The expression of carbonic anhydrase and CFTR remained unaltered when inflammatory signs were not detected in histological examinations.

Regulation (unaltered) of Gene_expression (expression) of CFTR

6) Confidence 0.26 Published 2006 Journal Pancreas Section Body Doc Link 17079941 Disease Relevance 0 Pain Relevance 0

The ATP release was affected by mutations in the CFTR protein, and it did not need Cl?

Regulation (affected) of Gene_expression (mutations) of CFTR protein

7) Confidence 0.24 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096548 Disease Relevance 0 Pain Relevance 0

CFTR is expressed in organ systems affected by cystic fibrosis, e.g. airways epithelia, the exocrine pancreas, the small intestine, the biliary tract and the male reproductive tract [37].

Regulation (affected) of Gene_expression (expressed) of CFTR in biliary tract associated with fibrosis and cystic fibrosis

8) Confidence 0.14 Published 2007 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2072944 Disease Relevance 0.49 Pain Relevance 0.22

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