INT139678

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Context Info
Confidence 0.68
First Reported 2006
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 23
Total Number 24
Disease Relevance 23.94
Pain Relevance 1.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hspb8) intracellular (Hspb8) response to stress (Hspb8)
cytoplasm (Hspb8)
Anatomy Link Frequency
hearts 2
blood 1
B-lymphocytes 1
lymphocytes 1
Hspb8 (Mus musculus)
Hspb8 - R120G (1)
Pain Link Frequency Relevance Heat
cytokine 94 99.98 Very High Very High Very High
Inflammation 277 95.60 Very High Very High Very High
fibrosis 60 92.16 High High
tolerance 20 88.12 High High
qutenza 4 85.16 High High
Central nervous system 12 82.08 Quite High
Inflammatory mediators 8 78.20 Quite High
Neuritis 2 75.00 Quite High
Neuropeptide 5 73.60 Quite High
Demyelination 1 67.24 Quite High
Disease Link Frequency Relevance Heat
Coronary Heart Disease 360 99.84 Very High Very High Very High
Targeted Disruption 1154 99.80 Very High Very High Very High
Nicotine Addiction 491 99.60 Very High Very High Very High
Rheumatoid Arthritis 27 99.28 Very High Very High Very High
Asthma 673 99.12 Very High Very High Very High
Immunization 26 97.96 Very High Very High Very High
Stress 88 97.92 Very High Very High Very High
Emphysema 12 97.88 Very High Very High Very High
Hypersensitivity 283 97.76 Very High Very High Very High
Sprains And Strains 125 97.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cardiac-specific TG mice expressing HSPB8 also inhibit the progression of cardiomyopathy in the R120G TG mice, suggesting that the induction of HSPB8 may play a role in inhibiting the development of DRM.
Positive_regulation (induction) of HSPB8 associated with targeted disruption and coronary heart disease
1) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 1.42 Pain Relevance 0.05
The present study confirms that induction of HSPB8 is beneficial for inhibiting DRM progression and that HSPB8 may play a critical role in mediating the protective effect of GGA.
Positive_regulation (induction) of HSPB8 associated with coronary heart disease
2) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 1.22 Pain Relevance 0.03
In contrast to NTG mice, GGA treatment markedly enhanced the induction of HSPB8 and HSPB1 in R120G TG mice (Figure 2D and E) with a slight induction of HSP70 (Figure 2D and E).
Positive_regulation (induction) of HSPB8 associated with targeted disruption
3) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 1.54 Pain Relevance 0.03
Further studies are needed to elucidate the underlying mechanism of HSPB8 induction in DRM.



Positive_regulation (induction) of HSPB8 associated with coronary heart disease
4) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 0.43 Pain Relevance 0
To clarify the functional role of HSPB8 induction on the development of HSPB5 R120G cardiomyopathy and test sufficiency, we generated a TG mouse, in which HSPB8 is overexpressed in a cardiac-specific manner using the inducible ?
Positive_regulation (induction) of HSPB8 associated with targeted disruption and coronary heart disease
5) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 1.45 Pain Relevance 0.03
HSP70 was significantly increased in NTG mice by oral administration of GGA (Figure 2D and E), whereas no obvious induction of small HSPs such as HSPB8, HSPB1 or HSPB5 was observed.
Neg (no) Positive_regulation (induction) of HSPB8 associated with targeted disruption
6) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 1.45 Pain Relevance 0
In the model tested here, we found that long-term treatment with GGA results in HSPB8 induction and a similar level of overexpression of HSPB8 via transgenic manipulation recapitulates the protective effect of GGA in HSPB5 R120G cardiomyopathy.
Positive_regulation (induction) of HSPB8 associated with targeted disruption and coronary heart disease
7) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 0.94 Pain Relevance 0
These studies suggest that HSP70 may play a role in HSPB8 induction in the hearts of HSPB5 R120G TG mice.
Positive_regulation (induction) of HSPB8 in hearts associated with targeted disruption
8) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 0.47 Pain Relevance 0
Further studies must address the effect of GGA on small HSP induction.
Positive_regulation (induction) of small HSP
9) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 1.27 Pain Relevance 0.04
HSP70 expression was significantly increased in the hearts of NTG mice treated with GGA, but there was no obvious induction in other small HSPs such as HSPB8, HSPB1 and HSPB5.
Neg (no) Positive_regulation (induction) of HSPB8 in hearts associated with targeted disruption
10) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 1.60 Pain Relevance 0.04
While GGA increased the expression levels of HSPB8 and HSPB1 as well as HSP70 in a dose-dependent manner, no induction of HSPB5 was observed (Figure 1A and B).
Positive_regulation (increased) of HSPB8
11) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 0.43 Pain Relevance 0
To evaluate the effect of HSPB8 on the development of the cardiac disease caused by the HSPB5 R120G mutation, HSPB5 R120G TG mice were crossbred with tTA/HSPB8 double transgenic (tTA/HSPB8 TG) mice to generate tTA/HSPB8/R120G triple transgenic mice (Triple TG).
Positive_regulation (generate) of HSPB8 (R120G) associated with targeted disruption and heart disease
12) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 1.55 Pain Relevance 0
Total and specific IgE are increased after treatment with all-transretinoic acid
Positive_regulation (increased) of IgE
13) Confidence 0.02 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2773769 Disease Relevance 0.25 Pain Relevance 0.03
Th2 cytokine induction and total IgE in airways by all transretinoic acid
Positive_regulation (induction) of IgE associated with cytokine
14) Confidence 0.02 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2773769 Disease Relevance 0.45 Pain Relevance 0.14
Levels of total and specific-IgE in sera were increased in all groups of RA treated OVA/OVA and HDM/HDM mice.
Positive_regulation (increased) of IgE associated with rheumatoid arthritis
15) Confidence 0.02 Published 2009 Journal Nutr Metab (Lond) Section Abstract Doc Link PMC2773769 Disease Relevance 1.20 Pain Relevance 0
were detected in supernatant of lymphocytes from BALB/c, BP/2, A/J, C57Bl/6 and CBA mice cultured with concanavaline A, along with an increase in total serum IgE.


Positive_regulation (increase) of IgE in lymphocytes
16) Confidence 0.01 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2935354 Disease Relevance 0.51 Pain Relevance 0.08
Increases in IL-4 were associated with increases in the total amount of B-lymphocytes and with proportional increases in total serum IgE.
Positive_regulation (increases) of IgE in B-lymphocytes
17) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935354 Disease Relevance 0.66 Pain Relevance 0.08
Because IgE levels in BALF are dependent upon IL-4, IL-5, IL-13 and may be considered
Positive_regulation (dependent) of IgE
18) Confidence 0.01 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.28 Pain Relevance 0.13
Maternal diets high in linoleic acid have been associated with increased cord blood IgE levels and increased asthma.
Positive_regulation (increased) of IgE in blood associated with asthma
19) Confidence 0.01 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440793 Disease Relevance 0.59 Pain Relevance 0.05
In contrast, the OSP-induced Abs were predominantly directed against OSP22-46; these Abs were mostly of IgG1 isotype, but high levels of IgG2a and IgG2b and significant levels of IgE were also observed.
Positive_regulation (levels) of IgE
20) Confidence 0.01 Published 2006 Journal J. Immunol. Section Abstract Doc Link 17082656 Disease Relevance 0.69 Pain Relevance 0.24

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