INT139764

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Context Info
Confidence 0.58
First Reported 2005
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 6.57
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CAV1) mitochondrion (CAV1) small molecule metabolic process (CAV1)
Golgi apparatus (CAV1) endoplasmic reticulum (CAV1) intracellular (CAV1)
Anatomy Link Frequency
chondrocytes 1
HPAF-II 1
CAV1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 3 99.46 Very High Very High Very High
antagonist 2 97.92 Very High Very High Very High
Kinase C 9 96.10 Very High Very High Very High
agonist 4 96.06 Very High Very High Very High
Inflammation 13 95.12 Very High Very High Very High
cytokine 5 94.08 High High
fibrosis 5 90.08 High High
Osteoarthritis 1 87.36 High High
adenocard 1 75.00 Quite High
Angina 1 61.04 Quite High
Disease Link Frequency Relevance Heat
Breast Cancer 5 99.96 Very High Very High Very High
Cancer 157 99.84 Very High Very High Very High
Targeted Disruption 6 99.64 Very High Very High Very High
INFLAMMATION 5 99.36 Very High Very High Very High
Metastasis 115 99.28 Very High Very High Very High
Aging 62 97.96 Very High Very High Very High
Adenocarcinoma 256 93.16 High High
Osteoarthritis 3 92.04 High High
Apoptosis 4 90.56 High High
Skin Cancer 5 90.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Administration of H2O2 to these chondrocytes induced cellular senescence via expression of the caveolin-1 protein, a mechanism reversed by antisense oligonucleotide-mediated downregulation of the caveolin-1 gene [19].
Negative_regulation (downregulation) of caveolin-1 gene in chondrocytes associated with aging
1) Confidence 0.58 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575636 Disease Relevance 1.33 Pain Relevance 0.20
In a tumor progression model of breast cancer, loss of cav-1 corresponded to increased metastasis, while ectopic expression of cav-1 inhibited metastasis[8].
Negative_regulation (loss) of cav-1 associated with cancer, breast cancer and metastasis
2) Confidence 0.56 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 1.09 Pain Relevance 0
Next we sought to establish whether loss of cav-1 was responsible for the increased migratory and invasive capabilities of the HPAF-II cells.
Spec (whether) Negative_regulation (loss) of cav-1 in HPAF-II
3) Confidence 0.56 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.38 Pain Relevance 0
These results suggest that high cav-1 expression may be associated with primary tumors, while loss of cav-1 may be associated with metastases.
Negative_regulation (loss) of cav-1 associated with cancer and metastasis
4) Confidence 0.56 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 1.20 Pain Relevance 0.05
Previous studies demonstrated that activation of p42/p44 extracellular regulated kinase (Erk) decreased cav-1 protein levels in constitutively-active Ras transformed NIH3T3 cells [38].
Negative_regulation (decreased) of cav-1 protein
5) Confidence 0.41 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.16 Pain Relevance 0.03
Furthermore, disruption of the Cav-1 gene in transgenic mice promotes mammary tumorigenesis and increased formation of metastases[9].
Negative_regulation (disruption) of Cav-1 associated with targeted disruption and metastasis
6) Confidence 0.41 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 1.26 Pain Relevance 0
Overall, our data suggest that a combination of COX-2 and HMG-R inhibitors synergistically inhibits caveolin-1 and its associated signaling pathways.
Negative_regulation (inhibits) of caveolin-1
7) Confidence 0.31 Published 2009 Journal Int. J. Oncol. Section Abstract Doc Link 19787257 Disease Relevance 0.18 Pain Relevance 0
Importantly, we demonstrated that activation of PKC-epsilon caused internalization of K(ATP) channels, the effect that was blocked by depletion of cholesterol with methyl-beta-cyclodextrin, expression of dominant-negative dynamin mutant K44E, or knockdown of caveolin-1 with small interfering RNA.
Negative_regulation (knockdown) of caveolin-1 associated with kinase c
8) Confidence 0.25 Published 2008 Journal Hypertension Section Abstract Doc Link 18663158 Disease Relevance 0.18 Pain Relevance 0.44
Moreover, hormones regulate the number of caveolae, with estrogen decreasing caveolin levels and thereby the number of caveolae, and progesterone having the opposite effect [25].
Negative_regulation (decreasing) of caveolin
9) Confidence 0.03 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2785819 Disease Relevance 0 Pain Relevance 0
In addition, these PPARgamma agonists modulate a number of antiproliferative and proapoptotic responses, including induction of p27, activating transcription factor 3, and nonsteroidal anti-inflammatory drug-activated gene-1 and down-regulation of cyclin D1 and caveolin-1.
Negative_regulation (regulation) of caveolin-1 associated with inflammation, cinod and agonist
10) Confidence 0.03 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17093136 Disease Relevance 0.43 Pain Relevance 0.24
Thus, this series of methylene-substituted diindolylmethane derivatives simultaneously activate multiple pathways in LNCaP cells, including ablation of androgen-responsiveness and down-regulation of caveolin-1.
Negative_regulation (regulation) of caveolin-1
11) Confidence 0.03 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17093136 Disease Relevance 0.35 Pain Relevance 0.18

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