INT139786

Context Info Confidence 0.12 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.89 Pain Relevance 0.11

cytoplasm (TNFAIP8, IKBKG) cytosol (IKBKG) nucleus (IKBKG) signal transducer activity (IKBKG)

TNFAIP8 (Homo sapiens) IKBKG (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 1 75.00 cINOD 1 70.24

Disease Link Frequency Relevance Heat Multiple Myeloma 7 97.52 Hypercalcemia 2 92.72 Chronic Lymphoid Leukemia 1 79.84 INFLAMMATION 2 75.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

SDX-308 effectively suppressed TNF-alpha-induced IKK-gamma and IkappaB-alpha phosphorylation and degradation and subsequent NF-kappaB activation in human multiple myeloma cells.

TNF-alpha-induced Positive_regulation (induced) of Phosphorylation (phosphorylation) of IKK-gamma associated with multiple myeloma

1) Confidence 0.12 Published 2007 Journal Blood Section Abstract Doc Link 17095620 Disease Relevance 0.89 Pain Relevance 0.11

General Comments

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