INT139927

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Context Info
Confidence 0.74
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.10
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gnrhr) plasma membrane (Gnrhr) signal transducer activity (Gnrhr)
Anatomy Link Frequency
primary neurons 1
brain 1
gonads 1
patterning 1
Gnrhr (Mus musculus)
Pain Link Frequency Relevance Heat
Action potential 8 98.44 Very High Very High Very High
Hippocampus 2 91.76 High High
Neurotransmitter 4 76.16 Quite High
tetrodotoxin 15 75.00 Quite High
gABA 7 75.00 Quite High
agonist 38 67.00 Quite High
GABAergic 8 53.52 Quite High
potassium channel 1 51.76 Quite High
Calcium channel 15 41.84 Quite Low
sodium channel 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Targeted Disruption 5 99.04 Very High Very High Very High
Primary Sclerosing Cholangitis 4 40.88 Quite Low
Reprotox - General 3 2 29.92 Quite Low
Hot Flashes 10 26.44 Quite Low
Uterine Cancer 1 23.56 Low Low
Cancer 5 5.00 Very Low Very Low Very Low
Breast Cancer 4 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 4 5.00 Very Low Very Low Very Low
Infection 3 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ovulation is initiated by a surge of gonadotropin-releasing hormone (GnRH) secretion by the brain.
Localization (secretion) of gonadotropin-releasing hormone in brain
1) Confidence 0.74 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17314287 Disease Relevance 0 Pain Relevance 0.12
Secretion from gonadotropin-releasing hormone (GnRH) neurons is necessary for the production of gametes and hormones from the gonads.
Localization (Secretion) of gonadotropin-releasing hormone in gonads
2) Confidence 0.60 Published 2010 Journal Brain Res. Section Abstract Doc Link 20580637 Disease Relevance 0 Pain Relevance 0.07
The brain controls fertility through release of gonadotropin-releasing hormone (GnRH), but the mechanisms underlying action potential patterning and GnRH release are not understood.
Localization (release) of gonadotropin-releasing hormone in patterning associated with action potential
3) Confidence 0.54 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 17108170 Disease Relevance 0 Pain Relevance 0.21
Besides using primary neurons or brain slices from animals, a neuronal cell line that can be continuously maintained in culture is the GT-1 cell line, which is an immortalized gonadotropin-releasing hormone (GnRH)-secreting cell line derived from transgenic mice [36].
Localization (secreting) of gonadotropin-releasing hormone in primary neurons associated with targeted disruption
4) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910705 Disease Relevance 0.10 Pain Relevance 0.18

General Comments

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