INT139976

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Context Info
Confidence 0.44
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 6.49
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Tp53) mitochondrion (Tp53) aging (Tp53)
endoplasmic reticulum (Tp53) enzyme binding (Tp53) protein complex assembly (Tp53)
Anatomy Link Frequency
brain 1
lung 1
nervous system 1
Tp53 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 5 97.38 Very High Very High Very High
Pain 2 79.36 Quite High
imagery 5 75.52 Quite High
Neuronal nitric oxide synthase 1 73.72 Quite High
anesthesia 14 72.16 Quite High
Spinal cord 17 68.08 Quite High
Inflammation 8 5.00 Very Low Very Low Very Low
ketamine 6 5.00 Very Low Very Low Very Low
dorsal root ganglion 6 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 133 100.00 Very High Very High Very High
Aging 41 99.98 Very High Very High Very High
Cancer 313 99.84 Very High Very High Very High
Pancreatic Cancer 5 99.58 Very High Very High Very High
Lung Cancer 12 99.34 Very High Very High Very High
Nervous System Malformation 1 99.08 Very High Very High Very High
Adenocarcinoma 1 98.40 Very High Very High Very High
Colon Cancer 25 98.16 Very High Very High Very High
Disease 54 97.36 Very High Very High Very High
Death 27 97.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prior to dilution, the Ad5CMV-p53 vials remained frozen at -60?
Regulation (frozen) of p53
1) Confidence 0.44 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816308 Disease Relevance 0.17 Pain Relevance 0
Many studies have been done to see the effect of p53 gene therapy on various tumors.
Regulation (effect) of p53 associated with cancer
2) Confidence 0.44 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816308 Disease Relevance 1.59 Pain Relevance 0
Zhang et al. assessed the infectivity and cytotoxicity of Ad5CMV-p53 on human lung cancer cells and suggested that Ad5CMV-p53 at a dose that is effective in cancer cells is not detrimental to normal cells (26).
Regulation (effective) of p53 in lung associated with lung cancer and cancer
3) Confidence 0.44 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816308 Disease Relevance 0.42 Pain Relevance 0
Nitrous oxide discretely up-regulates nNOS and p53 in neonatal rat brain.
Regulation (regulates) of p53 in brain
4) Confidence 0.33 Published 2010 Journal Minerva Anestesiol Section Title Doc Link 20473255 Disease Relevance 0.54 Pain Relevance 0.11
The cells were infected with Ad5CMV-p53 (5×108 vp), Ad5CMV (5×108 vp) or PBS as a control at days 1, 2, 3, 4, and 5 of incubation at 37?.
Regulation (control) of p53
5) Confidence 0.23 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816308 Disease Relevance 0.25 Pain Relevance 0
Twelve of 16 of the other genes demonstrating a significant difference in expression regulate axonal branching (Nf1; [39]); are various neuropeptides/neuropeptide receptors (Hcrt, Npffr2, Npy1r, Npy, Ppyr1); regulate transcription (Fus, Stat1 and Zfp110); modulate cellular signalling (Frs2); regulate apoptosis (Tp53); or is involved with nervous system development (Fgfr1).
Regulation (regulate) of Tp53 in nervous system associated with nervous system malformation, neuropeptide and apoptosis
6) Confidence 0.10 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 0.30 Pain Relevance 0.13
Pancreatic cancer is characterized by alterations in K-Ras, INK4a, Tp53 and SMAD4.
Regulation (alterations) of Tp53 associated with pancreatic cancer
7) Confidence 0.10 Published 2006 Journal Praxis Section Abstract Doc Link 17111879 Disease Relevance 1.40 Pain Relevance 0.15
Aging alters p53 function [51] and p53-related mechanisms are clearly involved in HD, possibly leading to mitochondrial anomalies [52].
Spec (possibly) Regulation (alters) of p53 associated with aging and disease
8) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645678 Disease Relevance 1.82 Pain Relevance 0

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