INT14

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Context Info
Confidence 0.57
First Reported 1976
Last Reported 2010
Negated 8
Speculated 1
Reported most in Body
Documents 22
Total Number 25
Disease Relevance 15.26
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (LDHA) small molecule metabolic process (LDHA) oxidoreductase activity (LDHA)
cytoplasm (LDHA)
Anatomy Link Frequency
PGE2 2
liver 1
muscle 1
pericytes 1
HGF 1
LDHA (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 7 100.00 Very High Very High Very High
anesthesia 10 97.92 Very High Very High Very High
lidocaine 5 97.36 Very High Very High Very High
Pain 61 85.96 High High
Angina 31 78.92 Quite High
halothane 2 75.00 Quite High
ischemia 52 73.32 Quite High
imagery 25 71.68 Quite High
Inflammatory response 3 71.00 Quite High
Inflammation 63 66.00 Quite High
Disease Link Frequency Relevance Heat
Chronic Hepatitis 62 100.00 Very High Very High Very High
Cirrhosis 115 99.76 Very High Very High Very High
Alagille Syndrome 52 99.56 Very High Very High Very High
Hypersensitivity 38 99.32 Very High Very High Very High
Injury 26 99.32 Very High Very High Very High
Necrosis 39 98.96 Very High Very High Very High
Hepatitis 75 98.76 Very High Very High Very High
Death 79 98.48 Very High Very High Very High
Diffuse Large B-cell Lymphoma 25 98.48 Very High Very High Very High
Hepatitis A Virus Infection 1 97.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our studies demonstrate that in human muscle: (1) total enzymatic activities and the expression of MSIs of GP and PGAM are regulated by neuronal effect(s); (2) total enzymatic activities of CK, LDH, and AChE depend mainly on muscle contractile activity; and (3) MSIs of CK and LDH are regulated predominantly by neuronal factors and to a much lesser degree by muscle contractile activity.
Regulation (regulated) of LDH in muscle
1) Confidence 0.57 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2152794 Disease Relevance 0.37 Pain Relevance 0.06
Some more interesting observations include the down-regulation of LDHA and FGF9 in HDM-allergic subjects after exposure to DEHPhigh house dust.
Regulation (regulation) of LDHA associated with hypersensitivity
2) Confidence 0.50 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2592268 Disease Relevance 0.43 Pain Relevance 0
After 3 h of stimulation the supernatant fluids were harvested and evaluated for prostaglandin E2 (PGE2), leukotriene B4 (LTB4), and lactate dehydrogenase (LDH).
Regulation (evaluated) of LDH in PGE2
3) Confidence 0.45 Published 1993 Journal Med Sci Sports Exerc Section Abstract Doc Link 8388071 Disease Relevance 0.54 Pain Relevance 0.10
After 3 h of stimulation the supernatant fluids were harvested and evaluated for prostaglandin E2 (PGE2), leukotriene B4 (LTB4), and lactate dehydrogenase (LDH).
Regulation (evaluated) of lactate dehydrogenase in PGE2
4) Confidence 0.45 Published 1993 Journal Med Sci Sports Exerc Section Abstract Doc Link 8388071 Disease Relevance 0.54 Pain Relevance 0.10
The immobilization of the NSAID ibuprofen (Hibp) and the Cu(II)-ibp compound on magnesium-aluminum layered double hydroxides (Mg3Al-LDH) is described.
Regulation (immobilization) of LDH associated with cinod
5) Confidence 0.44 Published 2005 Journal J Pharm Sci Section Abstract Doc Link 15793807 Disease Relevance 0 Pain Relevance 0.10
Together this suggests that HGF-mediated regeneration in human cirrhosis is similarly affected in canine CH, LDH, and CIRR.
Regulation (affected) of LDH in HGF associated with chronic hepatitis and cirrhosis
6) Confidence 0.35 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 1.43 Pain Relevance 0
Lactate dehydrogenase, hydroxybutyrate dehydrogenase and gamma-glutamyltransferase activities did not change significantly.
Neg (not) Regulation (change) of Lactate dehydrogenase
7) Confidence 0.30 Published 1976 Journal Clin. Chem. Section Abstract Doc Link 2391 Disease Relevance 0 Pain Relevance 0.58
Laboratory tests showed liver function tests normal (before the initial surgery however, after the surgery SGOT, SGPT, LDH were altered three times the normal range) hepatitis markers of HAV, HBV, HCV, and HIV were negative and alpha-fetoprotein (AFP) was 35 ng/ml.
Regulation (altered) of LDH in liver associated with acquired immune deficiency syndrome or hiv infection, hepatitis b virus infection, hepatitis c virus infection, hepatitis a virus infection and hepatitis
8) Confidence 0.26 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1403776 Disease Relevance 1.25 Pain Relevance 0.10
All three amines that inhibited NK activity also reduced the intracellular concentration of the lysosomal enzyme beta-glucuronidase without affecting the activity of the cytoplasmic enzyme lactate dehydrogenase.
Neg (without) Regulation (affecting) of lactate dehydrogenase
9) Confidence 0.25 Published 1983 Journal J. Immunol. Section Abstract Doc Link 6863915 Disease Relevance 0.08 Pain Relevance 0.41
A LDH level greater than 300 mg/dl is 98% sensitive for exudate; and levels of fluid/serum LDH greater than 0.6 is 94% sensitive for exudate.3,5,17
Regulation (sensitive) of LDH
10) Confidence 0.21 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2688157 Disease Relevance 0.70 Pain Relevance 0.38
Serum LDH is a sensitive marker for cell injury, but is a non specific test since the concentration is elevated in different circumstances of cell injury caused by ischaemia, as by excess heat or cold, starvation, dehydration, injury, exposure to bacterial toxins, after ingestion of certain drugs, and from chemical poisonings [25].
Regulation (sensitive) of Serum LDH associated with starvation, volume depletion and dehydration, cv unclassified under development, injury and poisoning
11) Confidence 0.20 Published 2010 Journal Respir Res Section Body Doc Link PMC2907324 Disease Relevance 1.10 Pain Relevance 0.03
Considerable changes were observed in total protein, albumin, lactate dehydrogenase (LDH), and C-reactive protein values in all macaques over time, but the changes were similar for all groups on days ?
Regulation (values) of LDH
12) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2942837 Disease Relevance 0.12 Pain Relevance 0
For comparison, LDH values from 63 NIH subjects with sequence verified hemoglobin SC disease or sickle ?
Regulation (values) of LDH associated with disease
13) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2330070 Disease Relevance 0.91 Pain Relevance 0.05
In the canine samples, an up regulation of the levels of phosphorylated ERK1/2 was observed in CH and LDH.
Regulation (regulation) of LDH associated with chronic hepatitis
14) Confidence 0.13 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 1.69 Pain Relevance 0.07
In NIH patients, LDH values were measured during steady state at initial evaluation with no acute crises or transfusion in the 2 weeks prior to evaluation.
Regulation (values) of LDH
15) Confidence 0.13 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2330070 Disease Relevance 0.92 Pain Relevance 0.05
The distribution of median LDH values for 451 subjects identified 113 in the top quartile and 111 in the bottom quartile (Figure 2C).
Regulation (values) of LDH
16) Confidence 0.13 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2330070 Disease Relevance 0.78 Pain Relevance 0.09
Of the 27 tests in which the target lactate levels were reached (at least 4 mM at t = 6 or 8 min, and remaining below 8 mM), the resulting exercise levels were too low in 7 and too high in 2.


Regulation (target) of lactate
17) Confidence 0.07 Published 2007 Journal Dig Dis Sci Section Body Doc Link PMC1914298 Disease Relevance 0 Pain Relevance 0
DPPH had no effect on media LDH levels in AGS cells but significantly raised levels in IEC-18 cells (Table 4).
Neg (no) Regulation (effect) of LDH in IEC-18 associated with alagille syndrome
18) Confidence 0.03 Published 2001 Journal BMC Complement Altern Med Section Body Doc Link PMC61450 Disease Relevance 1.38 Pain Relevance 0
Neither peroxynitrite or H2O2 at the concentrations chosen affected LDH levels in either AGS or IEC-18 cells, indicating that cell death by necrosis was minimal.
Regulation (affected) of LDH in AGS associated with necrosis, alagille syndrome and death
19) Confidence 0.03 Published 2001 Journal BMC Complement Altern Med Section Body Doc Link PMC61450 Disease Relevance 1.26 Pain Relevance 0.03
No affects were noted for lactate dehydrogenase (LDH).
Neg (No) Regulation (affects) of LDH
20) Confidence 0.03 Published 2007 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2206056 Disease Relevance 0 Pain Relevance 0

General Comments

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