INT140191

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 25
Total Number 26
Disease Relevance 13.47
Pain Relevance 9.71

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peptidase activity (Mmp13) extracellular space (Mmp13) extracellular region (Mmp13)
Golgi apparatus (Mmp13) proteinaceous extracellular matrix (Mmp13) lysosome (Mmp13)
Anatomy Mention Frequency
cartilage 12
chondrocytes 6
joints 6
TMJ 4
MEFs 2
Mmp13 (Mus musculus)
Pain Term Frequency Confidence Heat
rheumatoid arthritis 431 100.00 Very High Very High Very High
metalloproteinase 491 100.00 Very High Very High Very High
Snapping jaw 36 99.84 Very High Very High Very High
Osteoarthritis 635 99.84 Very High Very High Very High
cytokine 137 94.40 High High
Arthritis 285 92.00 High High
antagonist 18 83.84 Quite High
Inflammation 213 77.60 Quite High
Kinase C 1 67.52 Quite High
fibrosis 15 59.96 Quite High
Disease Term Frequency Confidence Heat
Rheumatoid Arthritis 431 100.00 Very High Very High Very High
Keloid Scars 50 99.90 Very High Very High Very High
Temporomandibular Joint Syndrome 36 99.84 Very High Very High Very High
Osteoarthritis 671 99.84 Very High Very High Very High
Injury 38 99.30 Very High Very High Very High
Burns 5 97.04 Very High Very High Very High
Cicatrix 14 96.64 Very High Very High Very High
Hypertrophy 32 93.52 High High
Osteogenic Sarcomas 1 93.44 High High
Arthritis 305 92.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: Results indicate that partial discectomy induces early-onset OA in mouse TMJ and that increased expression of Mmp-13, likely due to the elevated expression of Ddr2, may be one of the factors responsible for the early-onset OA in mouse TMJ.


Positive_regulation (increased) of Gene_expression (expression) of Mmp-13 in TMJ
1) Confidence 0.67 Published 2009 Journal Osteoarthr. Cartil. Section Body Doc Link 19230720 Disease Relevance 0.11 Pain Relevance 0
We conclude that, similar to previous observations in knee joints, the overexpression of Ddr2 and Mmp-13 may be responsible for the OA-like change in TM joints in mutant mice.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Mmp-13 in joints associated with osteoarthritis
2) Confidence 0.67 Published 2007 Journal Arch. Oral Biol. Section Abstract Doc Link 17125729 Disease Relevance 0.39 Pain Relevance 0.31
Age-dependent increase of discoidin domain receptor 2 and matrix metalloproteinase 13 expression in temporomandibular joint cartilage of type IX and type XI collagen-deficient mice.
Positive_regulation (increase) of Gene_expression (expression) of metalloproteinase 13 in temporomandibular joint associated with snapping jaw and metalloproteinase
3) Confidence 0.58 Published 2007 Journal Arch. Oral Biol. Section Title Doc Link 17125729 Disease Relevance 0.36 Pain Relevance 0.35
We also found that the overexpression of matrix metalloproteinase 13 (Mmp-13) was probably due to the up-regulation of a collagen receptor, discoidin domain receptor 2 (Ddr2), which was responsible for knee cartilage degeneration in mutant mice.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Mmp-13 in cartilage associated with metalloproteinase
4) Confidence 0.58 Published 2007 Journal Arch. Oral Biol. Section Abstract Doc Link 17125729 Disease Relevance 0.35 Pain Relevance 0.30
Mechanical compression of the wound may induce excessive scarring and influence the release of PGE2 and the expression of collagenases.
Positive_regulation (influence) of Gene_expression (expression) of collagenase associated with injury and keloid scars
5) Confidence 0.49 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2910481 Disease Relevance 1.96 Pain Relevance 0.27
The objective of our study was to determine whether the expression of Mmp-3, Mmp-13 and Ddr2 was increased in OA-like TM joints in mutant mice using immunohistochemistry.
Spec (whether) Positive_regulation (increased) of Spec (whether) Gene_expression (expression) of Mmp-13 in joints associated with osteoarthritis
6) Confidence 0.48 Published 2007 Journal Arch. Oral Biol. Section Abstract Doc Link 17125729 Disease Relevance 0.35 Pain Relevance 0.32
We found that the staining for Ddr2, Mmp-13 and Mmp-derived type II collagen fragments in tissue sections from 6-month-old mice was increased in TM joints of the mutant mice.
Positive_regulation (increased) of Gene_expression (staining) of Mmp-13 in joints
7) Confidence 0.48 Published 2007 Journal Arch. Oral Biol. Section Abstract Doc Link 17125729 Disease Relevance 0.33 Pain Relevance 0.32
All three hormone treatments increased the expression of procollagenase-1 in the presence of GM6001 or its control analog similarly to that shown in Fig. 1a,1b,1c.
Positive_regulation (increased) of Gene_expression (expression) of collagenase
8) Confidence 0.45 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064880 Disease Relevance 0 Pain Relevance 0.03
We also found that the overexpression of matrix metalloproteinase 13 (Mmp-13) was probably due to the up-regulation of a collagen receptor, discoidin domain receptor 2 (Ddr2), which was responsible for knee cartilage degeneration in mutant mice.
Positive_regulation (overexpression) of Gene_expression (overexpression) of metalloproteinase 13 in cartilage associated with metalloproteinase
9) Confidence 0.42 Published 2007 Journal Arch. Oral Biol. Section Abstract Doc Link 17125729 Disease Relevance 0.35 Pain Relevance 0.30
Cleaved fragments of collagen type II again can further induce MMP-13 gene expression and result in a cycle of collagen degradation.
Positive_regulation (induce) of Gene_expression (expression) of MMP-13
10) Confidence 0.41 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2925150 Disease Relevance 0.79 Pain Relevance 0.29
An increased propensity for extracellular matrix (ECM) remodeling is suggested by elevated expression of matrix metalloproteinases (Mmp3, Mmp9 and Mmp13), urokinase-type plasminogen activator (Plau) and secreted protease inhibitors (Serpina3g, Serpin2 and Lcn2).
Positive_regulation (elevated) of Gene_expression (expression) of Mmp13 in extracellular matrix associated with metalloproteinase
11) Confidence 0.30 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2529338 Disease Relevance 0.43 Pain Relevance 0.09
These observations indicate that ALK1 signaling can induce a chondrocyte phenotype similar to that found in OA cartilage, a phenotype with simultaneous enhanced expression of matrix molecules and MMP-13.
Positive_regulation (enhanced) of Gene_expression (expression) of MMP-13 in cartilage associated with osteoarthritis
12) Confidence 0.25 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.35 Pain Relevance 0.09
Moreover, chondrocytes in OA cartilage express high levels of matrix metalloproteinase 13 (MMP-13), the enzyme most potently degrading type II collagen [6].
Positive_regulation (levels) of Gene_expression (express) of matrix metalloproteinase 13 in cartilage associated with metalloproteinase and osteoarthritis
13) Confidence 0.25 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 1.02 Pain Relevance 0.51
To induce MMP-13 expression MEFs were treated for 5 hrs with 5 ng/ml PMA.


Positive_regulation (induce) of Gene_expression (expression) of MMP-13 in MEFs
14) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2781169 Disease Relevance 0.22 Pain Relevance 0.05
In addition, overexpression of constitutive active ALK5 (Smad2/3) results in increased expression of aggrecan while constitutive ALK1 (Smad1/5/8) expression leads to elevated expression of MMP-13.
Positive_regulation (elevated) of Gene_expression (expression) of MMP-13
15) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.25 Pain Relevance 0.06
Blocking ALK5 expression using siRNA resulted in elevated expression of MMP-13 [85].
Positive_regulation (elevated) of Gene_expression (expression) of MMP-13
16) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.26 Pain Relevance 0.06
Moreover, chondrocytes in OA cartilage express high levels of matrix metalloproteinase 13 (MMP-13), the enzyme most potently degrading type II collagen [6].
Positive_regulation (levels) of Gene_expression (express) of MMP-13 in cartilage associated with metalloproteinase and osteoarthritis
17) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 1.02 Pain Relevance 0.51
In conclusion, loss of the Smad2/3 signaling and relatively enhanced Smad1/5/8 signaling can explain the enigmatic observation in OA cartilage of elevated expression of both matrix molecules and proteolytic enzymes, like MMP-13.
Positive_regulation (elevated) of Gene_expression (expression) of MMP-13 in cartilage associated with osteoarthritis
18) Confidence 0.17 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.79 Pain Relevance 0.17
In our studies we observed maximal MMP-13 production (mean ± SEM) in RA FLS 24 hours after stimulation with IL-1?
Positive_regulation (after) of Gene_expression (production) of MMP-13 associated with rheumatoid arthritis and metalloproteinase
19) Confidence 0.15 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888198 Disease Relevance 0.61 Pain Relevance 1.04
However, not all MMPs were stimulated by gal-3 in chondrocytes, since collagenase-3 (MMP-13) was unaffected (data not shown).
Positive_regulation (since) of Neg (unaffected) Gene_expression (unaffected) of MMP-13 in chondrocytes associated with metalloproteinase
20) Confidence 0.12 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0.33 Pain Relevance 0.24

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