INT140336

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.64
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Csf1) extracellular space (Csf1) extracellular region (Csf1)
plasma membrane (Csf1)
Anatomy Link Frequency
macrophage 4
Csf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 19 98.96 Very High Very High Very High
withdrawal 10 93.40 High High
Peripheral nerve injury 3 79.60 Quite High
anesthesia 1 71.76 Quite High
Inflammatory response 2 42.00 Quite Low
Hippocampus 8 5.00 Very Low Very Low Very Low
Pyramidal cell 6 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 1 99.88 Very High Very High Very High
INFLAMMATION 20 98.96 Very High Very High Very High
Vasculitis 2 98.36 Very High Very High Very High
Cancer 84 97.84 Very High Very High Very High
Stress 6 97.32 Very High Very High Very High
Polyps 5 93.92 High High
Hypertension 4 92.08 High High
Pigmented Villonodular Synovitis 24 91.40 High High
Intestinal Polyposis 3 89.32 High High
Myxoid Liposarcoma 1 85.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Homozygous osteopetrotic (Op/Op) mice, deficient in macrophage colony-stimulating factor (m-CSF), exhibit reduced inflammation.
Negative_regulation (deficient) of macrophage colony-stimulating factor in macrophage associated with inflammation
1) Confidence 0.43 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 17142347 Disease Relevance 0.71 Pain Relevance 0.21
This model can be used to test the effects of a new generation of drug agents designed to block CSF1-recruited macrophage infiltration.
Negative_regulation (block) of CSF1-recruited in macrophage
2) Confidence 0.42 Published 2010 Journal Sarcoma Section Body Doc Link PMC2957133 Disease Relevance 1.53 Pain Relevance 0
Although it remains to be elucidated as to whether the loss of the CSF-1 function affects tumorigenesis, these results suggest that macrophages were required for the growth of Wnt/?
Spec (whether) Negative_regulation (loss) of CSF-1 in macrophages
3) Confidence 0.34 Published 2008 Journal EMBO J Section Body Doc Link PMC2413189 Disease Relevance 1.03 Pain Relevance 0
Similarly, studies in the op/op mice, a strain that lacks functional macrophage CSF-1 (colony stimulating factor-1), showed that in the absence of this growth factor, although microglia do not proliferate after peripheral nerve transection, synaptic withdrawal or removal still takes place (Kalla et al., 2001).
Negative_regulation (lacks) of CSF-1 in macrophage associated with sprains and strains and withdrawal
4) Confidence 0.16 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2954441 Disease Relevance 0.37 Pain Relevance 0.15

General Comments

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