INT140337

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Context Info
Confidence 0.50
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 42
Total Number 43
Disease Relevance 25.40
Pain Relevance 3.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cells 27
thymus 3
macrophages 2
B cells 2
anterior chamber 1
Cd8a (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 530 99.62 Very High Very High Very High
Prostatitis 28 98.36 Very High Very High Very High
rheumatoid arthritis 92 98.00 Very High Very High Very High
Demyelination 123 97.84 Very High Very High Very High
cytokine 322 97.16 Very High Very High Very High
agonist 28 81.36 Quite High
Central nervous system 36 77.32 Quite High
Spinal cord 33 65.52 Quite High
addiction 2 58.28 Quite High
tolerance 76 50.60 Quite High
Disease Link Frequency Relevance Heat
Hypersensitivity 121 100.00 Very High Very High Very High
Frailty 68 99.84 Very High Very High Very High
Immunization 183 99.64 Very High Very High Very High
INFLAMMATION 573 99.62 Very High Very High Very High
Necrosis 22 99.54 Very High Very High Very High
Cancer 215 99.36 Very High Very High Very High
Infection 750 99.02 Very High Very High Very High
Sprains And Strains 492 98.76 Very High Very High Very High
Aging 26 98.76 Very High Very High Very High
Reprotox - General 1 30 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that the induced expression of CD94 molecule is associated with the inhibitory effect of CD8+T cells following OVA inoculation into the anterior chamber.
Negative_regulation (effect) of CD8 in anterior chamber
1) Confidence 0.50 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0 Pain Relevance 0.10
As shown in Figure 5C, neutralization of TGF-beta1 was able to decrease the CD8+CD94+T cell suppressive activity by 27.4%.
Negative_regulation (decrease) of CD8 in T cell
2) Confidence 0.37 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.13 Pain Relevance 0
As both intracameral inoculation and conventional immunization could upregulate CD94-NKG2A expression, we examined the inhibitory effect of CD8+CD94+T cells from ACAID mice and immunized mice on the proliferation of splenic MNC in vitro.
Spec (examined) Negative_regulation (effect) of CD8 in T cells associated with immunization
3) Confidence 0.37 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.10 Pain Relevance 0
Given the different suppressive activity between CD8+CD94+T and CD8+CD94-T cells in ACAID mice, we thinks that CD8+Treg are mainly distributed in CD94+T subpopulation in ACAID.
Negative_regulation (distributed) of CD8 in T cells
4) Confidence 0.37 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0 Pain Relevance 0.07
Given the different suppressive activity between CD8+CD94+T and CD8+CD94-T cells in ACAID mice, we thinks that CD8+Treg are mainly distributed in CD94+T subpopulation in ACAID.
Negative_regulation (suppressive) of CD8 in T cells
5) Confidence 0.37 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0 Pain Relevance 0.08
A positive selection was performed and both CD8+CD94+T and CD8+CD94-T cells were isolated as described by the manufacturer.
Negative_regulation (isolated) of CD8 in T cells
6) Confidence 0.37 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0 Pain Relevance 0.07
Given the different suppressive activity between CD8+CD94+T and CD8+CD94-T cells in ACAID mice, we thinks that CD8+Treg are mainly distributed in CD94+T subpopulation in ACAID.
Negative_regulation (suppressive) of CD8 in T cells
7) Confidence 0.37 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0 Pain Relevance 0.08
In contrast, we found that OVA-AC-induced CD8+CD94+T cells did not influence the proliferation of splenic MNC from naive mice when exposed to polyclonal stimulation, this result seems to suggest a property of antigen-specific suppression of CD8+CD94+T cells in ACAID.
Negative_regulation (suppression) of CD8 in T cells
8) Confidence 0.37 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.06 Pain Relevance 0
A positive selection was performed and both CD8+CD94+T and CD8+CD94-T cells were isolated as described by the manufacturer.
Negative_regulation (isolated) of CD8 in T cells
9) Confidence 0.37 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0 Pain Relevance 0.07
It is tempting to propose here that the higher decrease in CD4+ and CD8+ populations on the thymus (associated with the comparatively larger stress-period, i.e. larger thymic-involution), would counteract the effect of the increased peripheral demand of T cells from thymus for these two cell subsets.
Negative_regulation (decrease) of CD8 in T cells associated with stress
10) Confidence 0.32 Published 2001 Journal BMC Immunol Section Body Doc Link PMC37547 Disease Relevance 0.57 Pain Relevance 0
Lymphopenic InsHA mice, coinjected with equal numbers of Clone 4 CD8+ and HNT CD4+ T cells, were treated every other day with 0,5 mg of the MR1 mAb.
Negative_regulation (numbers) of CD8 in T cells
11) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939396 Disease Relevance 0.27 Pain Relevance 0.03
Comparison of these respective peaks on day 12 to subsequent time points following immunization then indicates a decrease in CD4+ and CD8+ T cell populations.
Negative_regulation (decrease) of CD8 in T cell associated with immunization
12) Confidence 0.18 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2605729 Disease Relevance 0.44 Pain Relevance 0
The reduction of CD8+ T cell percentages in the spleen in addition to the suppression of their proliferation points to the possibility that important functional changes may be taking place in effector CD8+ T cells during the expression of ACAID.
Negative_regulation (reduction) of CD8 in T cells
13) Confidence 0.18 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2605729 Disease Relevance 0.14 Pain Relevance 0
-MSH to MC-1R was required for the reduction of contact allergy CD8+ T cells from C57BL/6Je/e mice were stimulated with ?
Negative_regulation (reduction) of CD8 in T cells associated with hypersensitivity
14) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813861 Disease Relevance 0.98 Pain Relevance 0
As shown in Fig. 3i–j, a great reduction in NRP-V7+CD8+CD19?
Negative_regulation (reduction) of CD8
15) Confidence 0.12 Published 2010 Journal Diabetologia Section Body Doc Link PMC2910887 Disease Relevance 0.67 Pain Relevance 0.14
This reduction was associated with a loss of CD4+CD8+ DP cells (Fig. 7D).
Negative_regulation (loss) of CD8 in DP cells
16) Confidence 0.12 Published 2007 Journal Virol J Section Body Doc Link PMC1810241 Disease Relevance 1.70 Pain Relevance 0
Severe thymus atrophy with a reduction of CD4 and CD8 double positive T cells was also observed in the lethal infection.


Negative_regulation (reduction) of CD8 in thymus associated with frailty and infection
17) Confidence 0.12 Published 2007 Journal Virol J Section Abstract Doc Link PMC1810241 Disease Relevance 1.75 Pain Relevance 0
Lethal infection with WR strain resulted in fewer lymphocytes and an altered phenotype of T cells in the lung compared to non-lethal infection and uninfected controls, and induced severe thymus atrophy with a marked reduction of CD4 and CD8 double positive (DP) T cells.


Negative_regulation (reduction) of CD8 in thymus associated with frailty, sprains and strains and infection
18) Confidence 0.12 Published 2007 Journal Virol J Section Body Doc Link PMC1810241 Disease Relevance 2.07 Pain Relevance 0
CD8 T cells were depleted in a similar manner using the anti-mouse CD8 MAb, TIB 210.
Negative_regulation (depleted) of CD8 in T cells
19) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743193 Disease Relevance 0.32 Pain Relevance 0
R deficient mice, due to a sharp decrease in CD8+ population recruited in the brain.
Negative_regulation (decrease) of CD8 in brain
20) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2442868 Disease Relevance 0.66 Pain Relevance 0.06

General Comments

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