INT140531

Context Info Confidence 0.72 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 1.83 Pain Relevance 1.34

signal transduction (Ngf) extracellular space (Ngf) aging (Ngf) extracellular region (Ngf) molecular_function (Ngf)

Anatomy Link Frequency nerve 1 Ngf (Rattus norvegicus) DYT10 (Homo sapiens)

Pain Link Frequency Relevance Heat Hyperalgesia 9 100.00 Kinase C 5 100.00 Nerve growth factor 3 100.00 Inflammation 1 98.84 Neuropathic pain 1 98.16 intrathecal 1 82.00 Pain 3 81.80 Analgesic 1 46.96

Disease Link Frequency Relevance Heat Hyperalgesia 9 100.00 Burns 9 100.00 INFLAMMATION 1 98.84 Neuropathic Pain 1 98.16 Injury 5 88.72 Pain 3 81.80

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Because nerve growth factor (NGF), which is elevated in burn-injured tissue, produces mechanical hyperalgesia and activates protein kinase C (PKC)-epsilon, a key mediator in inflammatory and neuropathic pain, we used this model to evaluate the role of the NGF receptor, tyrosine-receptor kinase A (TrkA), and PKC-epsilon in burn-induced primary mechanical hyperalgesia.

NGF Positive_regulation (activates) of PKC in nerve associated with kinase c, hyperalgesia, inflammation, nerve growth factor, burns and neuropathic pain

1) Confidence 0.72 Published 2006 Journal J Pain Section Abstract Doc Link 17157774 Disease Relevance 1.83 Pain Relevance 1.34

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