INT14054

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Context Info
Confidence 0.69
First Reported 1987
Last Reported 2008
Negated 1
Speculated 1
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 2.98
Pain Relevance 6.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (H2-Ab1) plasma membrane (H2-Ab1) intracellular (H2-Ab1)
transcription factor binding (H2-Ab1)
Anatomy Link Frequency
macrophages 1
neurons 1
nerves 1
sensory nerve 1
dorsal horn 1
H2-Ab1 (Mus musculus)
Pain Link Frequency Relevance Heat
Abeta 13 100.00 Very High Very High Very High
c fibre 11 100.00 Very High Very High Very High
Adelta 8 100.00 Very High Very High Very High
opioid receptor 3 100.00 Very High Very High Very High
Inflammation 44 99.92 Very High Very High Very High
Dorsal horn neuron 2 99.28 Very High Very High Very High
noradrenaline 4 99.12 Very High Very High Very High
Pain 7 98.08 Very High Very High Very High
spinal dorsal horn 1 97.88 Very High Very High Very High
Opioid 1 97.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 61 99.92 Very High Very High Very High
Ganglion Cysts 1 99.90 Very High Very High Very High
Injury 2 98.74 Very High Very High Very High
Convulsion 4 98.56 Very High Very High Very High
Pain 5 98.08 Very High Very High Very High
Herpes Simplex Virus Infection 5 97.88 Very High Very High Very High
Neuropathic Pain 5 96.36 Very High Very High Very High
Nociception 7 94.44 High High
Aging 17 93.84 High High
Hyperalgesia 2 81.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been used in patients to selectively activate Abeta-, Adelta- and C-fibres in the primary afferents at different stimulus frequencies (2000, 250 and 5 Hz, respectively).
Positive_regulation (activate) of Abeta associated with c fibre, adelta and abeta
1) Confidence 0.69 Published 2008 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 18380919 Disease Relevance 0.06 Pain Relevance 0.43
METHODS: The authors developed a nociception assay for mice using electrical stimuli at 2,000, 250, and 5 Hz that reportedly stimulate Abeta, Adelta, and C sensory nerve fibers, respectively.
Positive_regulation (stimulate) of Abeta in sensory nerve
2) Confidence 0.49 Published 2006 Journal Anesthesiology Section Body Doc Link 16871071 Disease Relevance 0.19 Pain Relevance 0
This may reflect an injury-induced maintenance of a normal developmental process whereby Abeta stimulation elicits c-fos in dorsal horn neurons.
Positive_regulation (stimulation) of Abeta in neurons associated with injury, dorsal horn neuron and abeta
3) Confidence 0.43 Published 2000 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 10675774 Disease Relevance 0.25 Pain Relevance 0.37
Abeta-, Adelta- and C-fibres were activated by transcutaneous electrical stimulation which also induced wind-up and post-discharge.
Positive_regulation (activated) of Abeta associated with c fibre, adelta and abeta
4) Confidence 0.43 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 11078928 Disease Relevance 0 Pain Relevance 0.63
Viral propagation in the sensory ganglion may induce mu-opioid receptor expression in Abeta fibers, which may be responsible for the inhibitory action of local opioids on mechanical allodynia in mice with herpetic pain.
Spec (may) Positive_regulation (induce) of Abeta in sensory ganglion associated with ganglion cysts, pain, allodynia, opioid receptor, herpes simplex virus infection, opioid and abeta
5) Confidence 0.37 Published 2008 Journal Neuroreport Section Abstract Doc Link 18521004 Disease Relevance 1.22 Pain Relevance 1.58
Specifically, the stimulation of A-beta, A-delta, and C-fibers is looked into, and responses from each of three different stimuli (5 Hz, 250 Hz, and 2000 Hz) are compared.
Positive_regulation (stimulation) of A-beta associated with c fibre
6) Confidence 0.37 Published 2008 Journal Int. J. Neurosci. Section Abstract Doc Link 18576211 Disease Relevance 0 Pain Relevance 0.20
Using extracellular recordings from single units, we demonstrate that large myelinated (Abeta) fibers are unchanged in prevalence and receptive properties.
Neg (unchanged) Positive_regulation (unchanged) of Abeta associated with abeta
7) Confidence 0.31 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10493751 Disease Relevance 0.08 Pain Relevance 0.72
The pro-convulsant action of alpha 2-adrenoceptor antagonists could be explained in terms of two mechanisms: a) blockade of endogenous noradrenaline which may normally exert a tonic anti-convulsant influence on seizure threshold, through post-synaptic alpha 2-receptors and/or b) increased activation of alpha 1- and beta-adrenoceptors by elevated synaptic noradrenaline levels following blockade of pre-synaptic alpha 2-adrenoceptors.
Positive_regulation (activation) of beta-adrenoceptors associated with convulsion, antagonist and noradrenaline
8) Confidence 0.10 Published 1991 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 1685254 Disease Relevance 0.31 Pain Relevance 0.61
-mediated induction of the MHC II gene (H2-Ab1) is impaired in macrophages from aged mice due to the decreased binding of transcription factors to the promoter [64].
Positive_regulation (induction) of H2-Ab1 in macrophages
9) Confidence 0.09 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2615427 Disease Relevance 0.13 Pain Relevance 0.08
Stimulation of Abeta fibers alone never evoked internalization in the superficial or deep dorsal horn.
Positive_regulation (Stimulation) of Abeta in dorsal horn associated with dorsal horn and abeta
10) Confidence 0.01 Published 1999 Journal J. Neurophysiol. Section Abstract Doc Link 10085363 Disease Relevance 0.46 Pain Relevance 0.94
All neurons also responded to electrical stimulation of hindlimb cutaneous nerves supramaximal for the activation of A-beta-, delta-, and C-fibers.
Positive_regulation (activation) of A-beta in nerves associated with c fibre
11) Confidence 0.01 Published 1987 Journal J. Neurophysiol. Section Abstract Doc Link 3655871 Disease Relevance 0.27 Pain Relevance 0.70

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