INT140888

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Context Info
Confidence 0.34
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.39
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (UCN3) extracellular region (UCN3)
Anatomy Link Frequency
intestine 1
UCN3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 12 98.44 Very High Very High Very High
antagonist 6 91.36 High High
spastic colon 3 75.76 Quite High
Disease Link Frequency Relevance Heat
Stress 3 99.00 Very High Very High Very High
Sensation Disorders 3 86.48 High High
Carcinoid 3 77.88 Quite High
Functional Bowel Disorder 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The CRF1/2 ligand, rat/human (r/h)CRF (EC50 = 233 nM), and the selective CRF2 ligand, human urocortin 3 (Ucn 3) (EC50 = 48 nM), induced a dose-dependent increase in cAMP formation.
Ucn 3 Binding (induced) of
1) Confidence 0.34 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17184738 Disease Relevance 0.08 Pain Relevance 0.20
The CRF1/2 ligand, rat/human (r/h)CRF (EC50 = 233 nM), and the selective CRF2 ligand, human urocortin 3 (Ucn 3) (EC50 = 48 nM), induced a dose-dependent increase in cAMP formation.
urocortin 3 Binding (induced) of
2) Confidence 0.34 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17184738 Disease Relevance 0.08 Pain Relevance 0.20
This suggests that EC cells may be a target for CRF and/or Ucn 3 in the intestine during stress-related responses.
Ucn 3 Binding (target) of in intestine associated with stress
3) Confidence 0.33 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17184738 Disease Relevance 0.24 Pain Relevance 0.33

General Comments

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