INT140888

Context Info Confidence 0.34 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 3 Disease Relevance 0.39 Pain Relevance 0.73

extracellular space (UCN3) extracellular region (UCN3)

Anatomy Link Frequency intestine 1 UCN3 (Homo sapiens)

Pain Link Frequency Relevance Heat Serotonin 12 98.44 antagonist 6 91.36 spastic colon 3 75.76

Disease Link Frequency Relevance Heat Stress 3 99.00 Sensation Disorders 3 86.48 Carcinoid 3 77.88 Functional Bowel Disorder 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The CRF1/2 ligand, rat/human (r/h)CRF (EC50 = 233 nM), and the selective CRF2 ligand, human urocortin 3 (Ucn 3) (EC50 = 48 nM), induced a dose-dependent increase in cAMP formation.

Ucn 3 Binding (induced) of

1) Confidence 0.34 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17184738 Disease Relevance 0.08 Pain Relevance 0.20

The CRF1/2 ligand, rat/human (r/h)CRF (EC50 = 233 nM), and the selective CRF2 ligand, human urocortin 3 (Ucn 3) (EC50 = 48 nM), induced a dose-dependent increase in cAMP formation.

urocortin 3 Binding (induced) of

2) Confidence 0.34 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17184738 Disease Relevance 0.08 Pain Relevance 0.20

This suggests that EC cells may be a target for CRF and/or Ucn 3 in the intestine during stress-related responses.

Ucn 3 Binding (target) of in intestine associated with stress

3) Confidence 0.33 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17184738 Disease Relevance 0.24 Pain Relevance 0.33

General Comments

This test has worked.