INT141014

From wiki-pain
Revision as of 21:31, 23 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.68
First Reported 2003
Last Reported 2011
Negated 1
Speculated 2
Reported most in Body
Documents 46
Total Number 48
Disease Relevance 47.63
Pain Relevance 13.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il18) extracellular region (Il18) cytoplasm (Il18)
Anatomy Link Frequency
microglia 14
brain 6
optic nerve 6
macrophages 4
ciliary body 4
Il18 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 822 100.00 Very High Very High Very High
cytokine 742 100.00 Very High Very High Very High
Hippocampus 178 100.00 Very High Very High Very High
ischemia 112 100.00 Very High Very High Very High
Dorsal horn 21 99.68 Very High Very High Very High
Arthritis 238 99.32 Very High Very High Very High
rheumatoid arthritis 190 99.20 Very High Very High Very High
Eae 42 99.16 Very High Very High Very High
psoriasis 3 98.72 Very High Very High Very High
chemokine 59 98.42 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 947 100.00 Very High Very High Very High
Arthritis 243 100.00 Very High Very High Very High
Cv Unclassified Under Development 76 100.00 Very High Very High Very High
Infection 121 99.98 Very High Very High Very High
Eczema 325 99.84 Very High Very High Very High
Brain Hemorrhage 47 99.80 Very High Very High Very High
Alzheimer's Dementia 75 99.72 Very High Very High Very High
Demyelinating Disease 63 99.68 Very High Very High Very High
Death 152 99.60 Very High Very High Very High
Nervous System Injury 63 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-18 overexpression has been variously reported in psoriasis, pulmonary inflammatory diseases, inflammatory bowel diseases, and various tumours, and therapeutic utility likely extends to a range of inflammatory conditions.
Positive_regulation (overexpression) of Gene_expression (overexpression) of IL-18 in bowel associated with psoriasis, inflammation, cancer and disease
1) Confidence 0.68 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064903 Disease Relevance 1.13 Pain Relevance 0.52
Moreover local overexpression of IL-18 binding protein c by adenoviral delivery also ameliorates articular destruction [5].
Positive_regulation (overexpression) of Gene_expression (overexpression) of IL-18 in articular
2) Confidence 0.68 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064903 Disease Relevance 0.75 Pain Relevance 0.34
Although other studies showed no differences in circulating IL-18 levels measured between AD patients (both mild cognitive impairment and severe AD patients) and controls [106,110,111], a significant increased production of IL-18 was obtained from stimulated blood mononuclear cells or macrophages of peripheral blood of AD patients [111,112].
Positive_regulation (increased) of Gene_expression (production) of IL-18 in macrophages associated with cognitive disorder and disease
3) Confidence 0.66 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 1.71 Pain Relevance 0.16
In addition, nerve injury induced a striking increase in IL-18 and IL-18R expression in the dorsal horn, and IL-18 and IL-18R were upregulated in hyperactive microglia and astrocytes, respectively [47,88].
Positive_regulation (increase) of Gene_expression (expression) of IL-18 in microglia associated with nervous system injury and dorsal horn
4) Confidence 0.66 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 1.05 Pain Relevance 0.58
For instance, infection of microglia lines with Theiler's murine encephalomyelitis virus (which causes the development of a chronic-progressive autoimmune demyelinating disease) significantly upregulates the expression of cytokines involved in innate immunity, including IL-18 [102].


Positive_regulation (upregulates) of Gene_expression (expression) of IL-18 in microglia associated with encephalitis, demyelinating disease, infection and cytokine
5) Confidence 0.66 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 1.90 Pain Relevance 0.42
In addition, IL-18 expression was elevated by restraint stress in the neurons of the medial habenula [56].
Positive_regulation (elevated) of Gene_expression (expression) of IL-18 in neurons associated with stress
6) Confidence 0.66 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.56 Pain Relevance 0.26
Our present study demonstrates that IL-18 gene and protein expression increase significantly with age in retina and optic nerve of DBA/2J mice.
Positive_regulation (increase) of Gene_expression (expression) of IL-18 in optic nerve
7) Confidence 0.64 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 1.11 Pain Relevance 0.21
We previously demonstrated that IL-18 gene and protein expression is significantly increased with age in iris/ciliary body and aqueous humor of DBA/2J mice.
Positive_regulation (increased) of Gene_expression (expression) of IL-18 in ciliary body
8) Confidence 0.64 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 1.18 Pain Relevance 0.22
In our previous work with DBA/2J mice, we demonstrated a correlation between elevated expression of interleukin-18 (IL-18) and the death of RGC [21].
Positive_regulation (elevated) of Gene_expression (expression) of interleukin-18 associated with death
9) Confidence 0.64 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 1.57 Pain Relevance 0.12
These data imply that a minor penetrating injury by i.c.v. injection of a small volume of buffer solution represents a procedure which is sensitive enough to induce significant IL-18 production in murine brains within 24 hours.
Positive_regulation (induce) of Gene_expression (production) of IL-18 in brains associated with injury
10) Confidence 0.62 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC506787 Disease Relevance 0.47 Pain Relevance 0.10
/IL-1 deficient mice, Joosten and colleagues subsequently demonstrated that whilst IL-18-induced joint inflammation is independent of IL-1, cartilage degradation requires IL-18 induced IL-1?
Neg (independent) Positive_regulation (independent) of Gene_expression (inflammation) of IL-18-induced in cartilage associated with inflammation and arthritis
11) Confidence 0.49 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064903 Disease Relevance 0.81 Pain Relevance 0.38
Upon IL-12 stimulation, native T cells develop into TH1 cells, expressing the IL-18R?
Positive_regulation (Upon) of Gene_expression (expressing) of IL-18 in T cells
12) Confidence 0.49 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.51 Pain Relevance 0.18
Work on IL-18 null, and on IL-18BP overexpressing mice indicated that IL-18 is anorexigenic and can modulate feeding, but also energy homeostasis, influencing obesity and insulin resistance [10,11].
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of IL-18 associated with metabolic syndrome and insulin resistance
13) Confidence 0.48 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.69 Pain Relevance 0.21
Thus, alternative IL-18R?
Positive_regulation (alternative) of Gene_expression (alternative) of IL-18R
14) Confidence 0.48 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 1.56 Pain Relevance 0.43
In addition, nerve injury induced a striking increase in IL-18 and IL-18R expression in the dorsal horn, and IL-18 and IL-18R were upregulated in hyperactive microglia and astrocytes, respectively [47,88].
Positive_regulation (increase) of Gene_expression (expression) of IL-18R in microglia associated with nervous system injury and dorsal horn
15) Confidence 0.48 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 1.05 Pain Relevance 0.58
In mouse hippocampus KA elevated IL-18 and IL-18R expression on microglial cells progressively 3 days after treatment [60].
Positive_regulation (elevated) of Gene_expression (expression) of IL-18 in microglial cells associated with hippocampus
16) Confidence 0.48 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.73 Pain Relevance 0.32
Although other studies showed no differences in circulating IL-18 levels measured between AD patients (both mild cognitive impairment and severe AD patients) and controls [106,110,111], a significant increased production of IL-18 was obtained from stimulated blood mononuclear cells or macrophages of peripheral blood of AD patients [111,112].
Positive_regulation (circulating) of Gene_expression (levels) of IL-18 in macrophages associated with cognitive disorder and disease
17) Confidence 0.48 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 1.77 Pain Relevance 0.16
may induce the synthesis of IL-18, and IL-18 kinases involved in tau phosphorylation as a part of the amyloid-associated inflammatory reaction.
Spec (may) Positive_regulation (induce) of Gene_expression (synthesis) of IL-18 associated with inflammation, eae and alzheimer's dementia
18) Confidence 0.48 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 1.54 Pain Relevance 0.32
may induce the synthesis of IL-18, and IL-18 kinases involved in tau phosphorylation as a part of the amyloid-associated inflammatory reaction.
Spec (may) Positive_regulation (induce) of Gene_expression (synthesis) of IL-18 associated with inflammation, eae and alzheimer's dementia
19) Confidence 0.48 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 1.55 Pain Relevance 0.32
is upregulated within 4 h of focal ischemia in rat brain, but IL-18 is upregulated much later, at time points associated with infiltration of peripheral immune cells, thus suggesting different roles for these interleukins in the regulation of glial functions [86].
Positive_regulation (upregulated) of Gene_expression (upregulated) of IL-18 in immune cells associated with ischemia
20) Confidence 0.48 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 1.55 Pain Relevance 0.48

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox