INT141054

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Context Info
Confidence 0.40
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 16
Disease Relevance 3.65
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (NFATC1) DNA binding (NFATC1) cytoplasm (NFATC1)
Anatomy Link Frequency
NFAT 1
NFATC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 7 98.80 Very High Very High Very High
antagonist 16 91.44 High High
agonist 12 88.96 High High
Opioid 4 78.72 Quite High
Morphine 3 78.20 Quite High
cytokine 107 77.36 Quite High
Kappa opioid receptor 1 75.44 Quite High
Paracetamol 3 75.00 Quite High
mu opioid receptor 2 75.00 Quite High
Endocannabinoid 1 71.00 Quite High
Disease Link Frequency Relevance Heat
Respiratory Syncytial Virus 348 99.68 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 987 98.92 Very High Very High Very High
Stress 3 96.24 Very High Very High Very High
Breast Cancer 13 79.52 Quite High
Cancer 97 57.68 Quite High
Hypercalcemia 42 54.96 Quite High
Fibromyalgia 18 49.04 Quite Low
Down Syndrome 4 44.64 Quite Low
Peripheral Arterial Disease 4 32.12 Quite Low
Hyperplasia 4 24.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that AM404 inhibited both the binding to DNA and the transcriptional activity of endogenous NFAT and the transcriptional activity driven by the over expressed fusion protein Gal4-NFAT (1-415).
NFAT Binding (binding) of
1) Confidence 0.40 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17196940 Disease Relevance 0 Pain Relevance 0.24
Interestingly also, NFATc1 and NF-?
NFATc1 Binding (also) of
2) Confidence 0.16 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.42 Pain Relevance 0
NFATc1 is thus downstream of several “signaling modules” and integrates them, whereas NF-?
NFATc1 Binding (integrates) of
3) Confidence 0.16 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.38 Pain Relevance 0
B/NFATc1, which is shown here to respond to the RSV analogues, they do not allow a full understanding of our data.
NFATc1 Binding (respond) of associated with respiratory syncytial virus
4) Confidence 0.16 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.73 Pain Relevance 0.12
NFAT was found to bind to three sequences of the mu-opioid receptor promoter, located at nucleotides -1064, -785, and -486.
NFAT Binding (bind) of in NFAT associated with opioid receptor
5) Confidence 0.15 Published 2008 Journal Mol. Pharmacol. Section Abstract Doc Link 18463202 Disease Relevance 0 Pain Relevance 0.73
The IL-11 promoter region contains two putative NFAT binding sites
NFAT Binding (binding) of
6) Confidence 0.07 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0
Moreover, using a specific inhibitor, INCA-6, which is known to block the interaction between calcineurin and NFAT (Roehrl et al., 2004), we have shown that inhibiting NFAT signalling can block PROK1-PROKR1 mediated expression of IL-11.
NFAT Binding (interaction) of
7) Confidence 0.07 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0.07
flank region we identified two correctly orientated putative NFAT binding sites at 1.642 and 5.138 kb from the start codon for IL-11 (Fig. 1D).


NFAT Binding (binding) of
8) Confidence 0.07 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0
Using a highly stringent search we have identified two correctly orientated putative NFAT binding sites within the IL-11 promoter.
NFAT Binding (binding) of
9) Confidence 0.07 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0.07
In addition to binding to the enhancer, NFAT binding at positions +169 to +181 has been reported to activate transcription [59,60,136].
NFAT Binding (binding) of
10) Confidence 0.06 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.52 Pain Relevance 0
NFAT can bind DNA as a high affinity dimer or as a lower affinity monomer [127-129].
NFAT Binding (bind) of
11) Confidence 0.06 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.14 Pain Relevance 0
Although this site can bind NFAT in vitro, this site was later shown not to be necessary for NFAT-mediated activation of the HIV-1 LTR [131,132].
NFAT Binding (bind) of associated with acquired immune deficiency syndrome or hiv infection
12) Confidence 0.06 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.24 Pain Relevance 0
NFAT binds the NF-?
NFAT Binding (binds) of
13) Confidence 0.06 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.23 Pain Relevance 0
Instead, NFAT binds the NF-?
NFAT Binding (binds) of
14) Confidence 0.06 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.31 Pain Relevance 0
NFAT proteins frequently cooperate with other transcription factor families when bound to adjacent sites within a promoter.
NFAT Binding (bound) of
15) Confidence 0.06 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.17 Pain Relevance 0
In addition to binding to the enhancer, NFAT binding at positions +169 to +181 has been reported to activate transcription [59,60,136].
NFAT Binding (binding) of
16) Confidence 0.04 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.52 Pain Relevance 0

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