INT14106

Context Info Confidence 0.51 First Reported 1991 Last Reported 2006 Negated 0 Speculated 1 Reported most in Abstract Documents 4 Total Number 7 Disease Relevance 3.85 Pain Relevance 2.78

extracellular space (Abp1) oxidoreductase activity (Abp1) extracellular region (Abp1) plasma membrane (Abp1) biological_process (Abp1)

Anatomy Link Frequency blood 2 bladder 1 Abp1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat agonist 4 99.44 Inflammation 123 98.84 fluoxetine 2 98.00 cva 1 96.28 headache 11 88.56 intrathecal 2 85.76 Spinal cord 4 83.76 allodynia 6 83.12 Antihistamine 1 82.96 cerebral cortex 1 81.84

Disease Link Frequency Relevance Heat Nociception 39 99.46 INFLAMMATION 132 98.84 Hemorrhage 1 96.28 Pressure Volume 2 Under Development 1 94.80 Hypertension 4 92.52 Headache Disorders 3 89.20 Neuropathic Pain 6 83.12 Dyspepsia 3 80.20 Disease 2 79.04 Hypotension 2 78.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Unilateral chemical stimulation of the VLPA in these rats increased ABP but it remained within normotensive range.

Positive_regulation (increased) of ABP

1) Confidence 0.51 Published 1991 Journal Brain Res. Section Abstract Doc Link 1686212 Disease Relevance 0.25 Pain Relevance 0.12

It was further observed that ith of 8-OH-DAPT (2.5, 5, 10 micrograms/10 microliters), a 5-HT1A receptor agonist, produced a dose-dependent increase of mABP and lowering of HR.

Positive_regulation (increase) of mABP associated with agonist

2) Confidence 0.46 Published 1991 Journal Sheng Li Xue Bao Section Abstract Doc Link 1796318 Disease Relevance 0.24 Pain Relevance 0.33

Ith administration of fluoxetine (10 micrograms/microliters), one of the presynaptic reuptake inhibitors of 5-HT, produced a marked increase in the mean arterial blood pressure (mABP).

Positive_regulation (increase) of mABP in blood associated with fluoxetine

3) Confidence 0.40 Published 1991 Journal Sheng Li Xue Bao Section Abstract Doc Link 1796318 Disease Relevance 0.21 Pain Relevance 0.29

It is notable that in the present studies there was an apparent temporal dissociation between local tissue inflammatory changes and the enhancement of reflex responses to bladder stimulation: statistically significant evidence of inflammation occurred prior to (4 and 12 hr) the development of robust and statistically significant enhancement of ABP and EMG responses to UBD which only occurred 24 hr after administration of zymosan.

Positive_regulation (responses) of ABP in bladder associated with inflammation

4) Confidence 0.39 Published 2006 Journal BMC Urol Section Body Doc Link PMC1395324 Disease Relevance 0.75 Pain Relevance 0.32

As supportive treatment, a vitamin B6 (pyridoxal phosphate) substitution appears useful in histamine-intolerant patients as pyridoxal phosphate seems to be crucial for diamine oxidase activity.

Spec (seems) Positive_regulation (crucial) of diamine oxidase

5) Confidence 0.32 Published 1996 Journal Int. Arch. Allergy Immunol. Section Abstract Doc Link 8645981 Disease Relevance 0.75 Pain Relevance 0.77

Statistically significant increases in ABP and EMG responses to UBD also occurred 24 hr post-zymosan administration but not at earlier timepoints.

Positive_regulation (increases) of ABP

6) Confidence 0.32 Published 2006 Journal BMC Urol Section Body Doc Link PMC1395324 Disease Relevance 0.56 Pain Relevance 0.59

In the studies of inflammation-induced changes in nociception, arterial blood pressure (ABP) and visceromotor responses to graded distension of the urinary bladder were significantly increased relative to controls 24 hr after zymosan administration.

Positive_regulation (increased) of ABP in blood associated with nociception and inflammation

7) Confidence 0.32 Published 2006 Journal BMC Urol Section Abstract Doc Link PMC1395324 Disease Relevance 1.02 Pain Relevance 0.36

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