INT141082

Context Info Confidence 0.15 First Reported 2005 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 6 Total Number 7 Disease Relevance 3.56 Pain Relevance 1.26

Anatomy Link Frequency CD86 1 thyroid 1 spinal cord 1 brainstem 1 Atp9a (Mus musculus)

Pain Link Frequency Relevance Heat medulla 10 99.20 Spinal cord 10 98.64 metalloproteinase 1 95.32 Pain 2 95.24 Thalamus 2 93.04 Hippocampus 2 92.52 Inflammation 70 50.00 Dorsal horn 2 47.52 cytokine 41 46.80 chemokine 16 27.52

Disease Link Frequency Relevance Heat Candida Infection 274 98.60 Cancer 71 96.24 Disease 36 95.28 Pain 2 95.24 Metastasis 10 73.72 Colitis 37 59.64 Targeted Disruption 23 52.24 INFLAMMATION 63 50.00 Hypersensitivity 59 50.00 Death 6 47.36

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Although CIITA was initially described as a master regulator of MHC class II transcription, it is now clear that it can both activate and suppress transcription of several genes such as collagen (6), matrix metalloproteinase-9 (7), IL-4 (8), Fas ligand (9) and thyroid specific genes (10, 11).

Transcription (transcription) of class II in thyroid associated with metalloproteinase

1) Confidence 0.15 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 0.11 Pain Relevance 0.05

The number of MHC class II+ CD80+ was further greater in the CSBG + OVA group than in the OVA group (P < 0.05).

Transcription (number) of class II associated with candida infection

2) Confidence 0.05 Published 2009 Journal Respir Res Section Body Doc Link PMC2731726 Disease Relevance 1.30 Pain Relevance 0

Furthermore, the number of MHC class II+ CD80+ or MHC class II+ CD86+ cells was also greater in the CSBG + OVA group than in the vehicle group (P < 0.05 for MHC class II+ CD86+, P < 0.01 for MHC class II+ CD80+).

Transcription (number) of class II in CD86 associated with candida infection

3) Confidence 0.05 Published 2009 Journal Respir Res Section Body Doc Link PMC2731726 Disease Relevance 1.32 Pain Relevance 0

Such a correlation was not demonstrated for HER2, Top IIa, Ki 67 or p53.

Neg (not) Transcription (demonstrated) of IIa

4) Confidence 0.04 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410751 Disease Relevance 0.64 Pain Relevance 0

Of the isoforms, sPLA(2)-IIA mRNA expression was highest in the brainstem and spinal cord suggesting that this could be the most relevant isoform in the ascending pain pathway.

Transcription (expression) of IIA in spinal cord associated with pain, medulla and spinal cord

5) Confidence 0.02 Published 2010 Journal J. Chem. Neuroanat. Section Abstract Doc Link 20153419 Disease Relevance 0.10 Pain Relevance 0.61

Compared with normal saline group, COX-1 mRNA expression of the groups (Ia, Ib, Id, IIa, IIb and IId) increased (0.384 +/- 0.031, 0.354 +/- 0.026, 0.753 +/- 0.049, 0.366 +/- 0.035, 0.381 +/- 0.036, 0.766 +/- 0.401, P < 0.001) while COX-2 mRNA expression of the above groups decreased statistically (0.483 +/- 0.056, 0.448 +/- 0.046, 0.461 +/- 0.050, 0.479 +/- 0.032, P < 0.001).

Transcription (expression) of IIa

6) Confidence 0.02 Published 2006 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 17200026 Disease Relevance 0 Pain Relevance 0

Of the isoforms, sPLA(2)-IIA mRNA expression was highest in the brainstem and spinal cord suggesting that this could be the most relevant isoform in the ascending pain pathway.

Transcription (expression) of IIA in brainstem associated with pain, medulla and spinal cord

7) Confidence 0.01 Published 2010 Journal J. Chem. Neuroanat. Section Abstract Doc Link 20153419 Disease Relevance 0.10 Pain Relevance 0.61

General Comments

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