INT141191

Context Info Confidence 0.48 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 2.33 Pain Relevance 1.85

cytosol (Apaf1) Golgi apparatus (Apaf1) nucleus (Apaf1) intracellular (Apaf1) cytoplasm (Apaf1)

Anatomy Link Frequency dorsal horn spinal cord 4 Apaf1 (Mus musculus)

Pain Link Frequency Relevance Heat Dorsal horn 4 99.04 Neuropathic pain 8 99.00 Spinal cord 10 98.56 Eae 12 97.56 Sciatic nerve 6 96.32 Thermal hyperalgesia 2 73.20 allodynia 2 70.32 Pain 6 25.00

Disease Link Frequency Relevance Heat Apoptosis 14 100.00 Neuropathic Pain 10 99.00 Injury 12 96.72 Hyperalgesia 2 73.20

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

RT-PCR analysis showed increased expression of bax, apoptotic protease-activating factor-1 (apaf-1), and caspase-9 in the dorsal horn spinal cord 3 days after chronic constriction injury of sciatic nerve.

Positive_regulation (increased) of Gene_expression (expression) of apaf-1 in dorsal horn spinal cord associated with eae, injury, dorsal horn, sciatic nerve, apoptosis and spinal cord

1) Confidence 0.48 Published 2007 Journal Pharmacol. Res. Section Abstract Doc Link 17207636 Disease Relevance 1.17 Pain Relevance 0.93

RT-PCR analysis showed increased expression of bax, apoptotic protease-activating factor-1 (apaf-1), and caspase-9 in the dorsal horn spinal cord 3 days after chronic constriction injury of sciatic nerve.

Positive_regulation (increased) of Gene_expression (expression) of apoptotic protease-activating factor-1 in dorsal horn spinal cord associated with eae, injury, dorsal horn, sciatic nerve, apoptosis and spinal cord

2) Confidence 0.48 Published 2007 Journal Pharmacol. Res. Section Abstract Doc Link 17207636 Disease Relevance 1.17 Pain Relevance 0.92

General Comments

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