INT141194

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.57
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Tnf) signal transduction (Tnf) extracellular space (Tnf)
extracellular region (Tnf) plasma membrane (Tnf) intracellular (Tnf)
Tnf (Mus musculus)
Pain Link Frequency Relevance Heat
Antinociceptive 4 99.16 Very High Very High Very High
Inflammation 5 98.76 Very High Very High Very High
psoriasis 11 98.40 Very High Very High Very High
rheumatoid arthritis 1 68.40 Quite High
spinal inflammation 1 65.92 Quite High
Arthritis 1 53.12 Quite High
cytokine 1 50.00 Quite Low
Glutamate 1 50.00 Quite Low
Analgesic 3 25.00 Low Low
Etanercept 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Necrosis 3 99.70 Very High Very High Very High
Cancer 3 99.52 Very High Very High Very High
INFLAMMATION 5 98.76 Very High Very High Very High
Psoriasis 14 98.40 Very High Very High Very High
Rheumatoid Arthritis 1 68.40 Quite High
Low Back Pain 1 65.92 Quite High
Crohn's Disease 1 61.68 Quite High
Synovitis 1 59.28 Quite High
Acne 1 58.48 Quite High
Hyperostosis 1 57.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: Our results suggest that inhibition of glutamatergic metabotropic receptors and TNF-alpha may account for the antinociceptive action reported for the HE in models of chemical pain used in this study.


Regulation (account) of Negative_regulation (inhibition) of TNF-alpha
1) Confidence 0.42 Published 2009 Journal J Ethnopharmacol Section Body Doc Link 19429314 Disease Relevance 0 Pain Relevance 0
Taken together, our data indicate that the anti-inflammatory and antinociceptive properties of siegeskaurolic acid may be due to iNOS, COX-2 and TNF-alpha inhibition via the down-regulation of NF-kappaB binding activity.
Regulation (due) of Negative_regulation (inhibition) of TNF-alpha associated with inflammation and antinociceptive
2) Confidence 0.22 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17207792 Disease Relevance 0.45 Pain Relevance 0.23
Tumor necrosis factor-alpha (TNFalpha) inhibition is effective in the treatment of moderate-to-severe psoriasis.
Regulation (effective) of Negative_regulation (inhibition) of TNFalpha associated with psoriasis, necrosis and cancer
3) Confidence 0.11 Published 2008 Journal Am J Clin Dermatol Section Abstract Doc Link 18092839 Disease Relevance 1.12 Pain Relevance 0.25

General Comments

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