INT1415

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Context Info
Confidence 0.16
First Reported 1977
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.30
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (POMC) Golgi apparatus (OPRM1) endoplasmic reticulum (OPRM1)
cell-cell signaling (POMC) cytoplasm (POMC) signal transducer activity (OPRM1)
Anatomy Link Frequency
vas deferens 1
OPRM1 (Homo sapiens)
POMC (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 4 100.00 Very High Very High Very High
opiate 2 100.00 Very High Very High Very High
Morphine 2 99.64 Very High Very High Very High
cytokine 8 85.24 High High
Endogenous opioid 2 82.96 Quite High
Neuropeptide 1 79.20 Quite High
depression 1 64.40 Quite High
Disease Link Frequency Relevance Heat
Necrosis 1 87.64 High High
Cancer 1 87.28 High High
Depression 1 64.40 Quite High
Disease 1 62.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, serum concentrations of IL-6, TNF-alpha, and IFN-gamma were significantly lower and the general health score was significantly higher in carriers of the G allele, who show a strong binding of beta-endorphin to the mu-opioid receptor as compared to individuals without the G allele.
mu-opioid receptor Binding (binding) of beta-endorphin associated with opioid receptor
1) Confidence 0.16 Published 2009 Journal Brain Behav. Immun. Section Abstract Doc Link 19341791 Disease Relevance 0.30 Pain Relevance 0.56
This indicates that alpha-endorphin influences the PFC response via opiate receptor interaction.
opiate receptor Binding (interaction) of alpha-endorphin associated with opiate
2) Confidence 0.13 Published 1986 Journal J. Immunol. Section Abstract Doc Link 2415618 Disease Relevance 0 Pain Relevance 0.14
The morphine-like activity of beta-endorphin is comparable both in the mouse vas deferens bioassay and in the opiate receptor binding assay.
opiate receptor Binding (assay) of beta-endorphin in vas deferens associated with opiate and morphine
3) Confidence 0.09 Published 1977 Journal Can. J. Biochem. Section Abstract Doc Link 195688 Disease Relevance 0 Pain Relevance 0.27

General Comments

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