INT141605

Context Info Confidence 0.34 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.80

histone binding (Ctsl) vacuole (Ctsl) cytoplasm (Ctsl) cell proliferation (MET) peptidase activity (Ctsl) signal transduction (MET)

Ctsl (Mus musculus) MET (Homo sapiens)

Pain Link Frequency Relevance Heat Enkephalin 12 99.96 Neurotransmitter 2 91.08 Neuropeptide 4 82.80 Nicotine 1 80.56 Opioid 1 34.16

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Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Expression of cathepsin L resulted in highly increased cellular levels of (Met)enkephalin, resulting from the conversion of PE to enkephalin-containing intermediates of 23, 18-19, 8-9, and 4.5 kDa that were similar to those present in vivo.

Gene_expression (Expression) of cathepsin L Positive_regulation (resulted) of Positive_regulation (increased) of Met associated with enkephalin

1) Confidence 0.34 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17244622 Disease Relevance 0 Pain Relevance 0.80

General Comments

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