INT141706

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.87
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DRB1) Golgi apparatus (HLA-DRB1) endoplasmic reticulum (HLA-DRB1)
plasma membrane (HLA-DRB1)
Anatomy Link Frequency
immune cells 1
Lym-1 1
body 1
cytotoxic T lymphocytes 1
HLA-DRB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 7 98.76 Very High Very High Very High
Inflammation 10 89.56 High High
imagery 26 72.80 Quite High
headache 9 66.20 Quite High
Central nervous system 9 64.84 Quite High
Enkephalin 1 59.84 Quite High
potassium channel 1 55.52 Quite High
Multiple sclerosis 51 52.48 Quite High
positron emission tomography 1 46.52 Quite Low
Inflammatory mediators 1 11.68 Low Low
Disease Link Frequency Relevance Heat
Pleural Effusion 6 97.24 Very High Very High Very High
Dengue Hemorrhagic Fever 278 96.48 Very High Very High Very High
Lymphatic System Cancer 8 95.92 Very High Very High Very High
Fatigue 3 92.16 High High
Infection 84 89.60 High High
INFLAMMATION 11 89.56 High High
Dengue 42 88.00 High High
Hepatitis B Virus Infection 2 87.32 High High
Hepatitis 4 86.80 High High
Hepatitis C Virus Infection 4 86.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sequencing of HLA-DRB1 alleles
Localization (Sequencing) of HLA-DRB1
1) Confidence 0.75 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2743806 Disease Relevance 0 Pain Relevance 0
Determination of HLA-DRB1 allele
Localization (Determination) of HLA-DRB1
2) Confidence 0.75 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2743806 Disease Relevance 1.01 Pain Relevance 0.07
Even though the extent of linkage disequilibrium between HLA-A3 and HLA-DRB1*1501 is modest (D?
Localization (disequilibrium) of HLA-DRB1
3) Confidence 0.51 Published 2008 Journal Brain Section Body Doc Link PMC2639203 Disease Relevance 0.05 Pain Relevance 0.03
Phenotype frequencies of HLA-A, HLA-B and HLA-DRB1
Localization (frequencies) of HLA-DRB1
4) Confidence 0.49 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2553281 Disease Relevance 0.74 Pain Relevance 0
Possibly there is a common primary associated gene closely located to DRB1 locus, such as HLA-DQB1 and HLA-DRB4, for those alleles (DRB1*07 and DRB1*04) and Vietnamese DRB1*0901.
Localization (located) of DRB1
5) Confidence 0.49 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2553281 Disease Relevance 1.53 Pain Relevance 0
Created as radionuclide targeting molecules, these SHALs were intended to have the human leukocyte antigen-DR (HLA-DR) selectivity of Lym-1 mAb and the pharmacokinetics of a small molecule.
Localization (selectivity) of antigen-DR in Lym-1
6) Confidence 0.36 Published 2006 Journal Cancer Biother. Radiopharm. Section Abstract Doc Link 17257080 Disease Relevance 0.27 Pain Relevance 0.06
Surgery rehearsal with prototypes allowed us to choose the best location of the DRB, thereby increasing rigid body visibility.
Localization (location) of DRB in body
7) Confidence 0.33 Published 2010 Journal Sarcoma Section Body Doc Link PMC2993049 Disease Relevance 0.11 Pain Relevance 0.04
These included genes encoding proteins involved in intracellular antigen processing and transport for eventual surface presentation to immune cells (PSMB8, TAP1), antigen presentation proteins, including HLA class I molecules (HLA-A, HLA-C, HLA-F, and HLA-G) and HLA class II molecules (HLA-DRB1, DRB4, DRB5, DPA1, and DPB1), cytokines involved in the recruitment of monocytes (SCYA3, SCYA4, CD14), and cytokine receptors (IL1R2, IL4R, and IL6R).
Localization (molecules) of HLA-DRB1 in immune cells associated with cytokine
8) Confidence 0.08 Published 2005 Journal Genome Biol Section Body Doc Link PMC1242209 Disease Relevance 0.30 Pain Relevance 0.12
An increased number of CD8+ cytotoxic T lymphocytes and CD38 and HLA-DR activation markers have been reported, and a decrease in CD11b expression associated with an increased expression of CD28+ T subsets has been observed.
Localization (number) of HLA-DR in cytotoxic T lymphocytes
9) Confidence 0.02 Published 2009 Journal Autoimmun Rev Section Abstract Doc Link 18801465 Disease Relevance 0.87 Pain Relevance 0.16

General Comments

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