INT141936

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Context Info
Confidence 0.80
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 10.59
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mapt) cytoskeleton (Mapt) nucleus (Mapt)
enzyme binding (Mapt) cytoplasm (Mapt)
Anatomy Link Frequency
brain 2
covering 1
neurons 1
Mapt (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 22 100.00 Very High Very High Very High
Central nervous system 5 97.92 Very High Very High Very High
Hippocampus 20 96.96 Very High Very High Very High
Inflammation 45 94.00 High High
Pyramidal cell 72 92.32 High High
anesthesia 3 88.72 High High
amygdala 9 83.40 Quite High
alcohol 1 64.32 Quite High
imagery 56 45.60 Quite Low
positron emission tomography 27 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuroblastoma 9 99.84 Very High Very High Very High
Starvation 1 99.08 Very High Very High Very High
Targeted Disruption 153 97.92 Very High Very High Very High
Disease 706 97.88 Very High Very High Very High
Amyloid Plaque 99 96.68 Very High Very High Very High
Alzheimer's Dementia 233 95.20 Very High Very High Very High
INFLAMMATION 57 94.00 High High
Stress 34 91.84 High High
Tauopathy 159 90.48 High High
Cognitive Disorder 94 89.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tau is reversibly hyperphosphorylated in the mouse brain by starvation or cold water swimming.
Phosphorylation (hyperphosphorylated) of Tau in brain associated with starvation
1) Confidence 0.80 Published 2007 Journal FEBS Lett. Section Abstract Doc Link 17289030 Disease Relevance 0.26 Pain Relevance 0.25
Their widely different grading of phosphorylation is usually referred to as hyperphosphorylated Tau, denoted here as hP-Tau.
Phosphorylation (hyperphosphorylated) of Tau
2) Confidence 0.79 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2938448 Disease Relevance 1.38 Pain Relevance 0.04
Most interesting for the interpretation of the data obtained with protein Tau, discussed in the next section, was the observation that at 6 months p.i. the phosphorylation of endogenous mouse Tau was increased and coincided with a minor but significant reduction in the number of neurons in the CA1 region of AAV-APP.SLA injected mice [30].

2.2.

Phosphorylation (phosphorylation) of Tau in neurons
3) Confidence 0.61 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2938448 Disease Relevance 0.28 Pain Relevance 0.13
These pathways obligatory involve kinases such as GSK3 [25, 26] that contribute, directly or indirectly to the phosphorylation of Tau at residues that affect its binding to microtubuli.
Phosphorylation (phosphorylation) of Tau
4) Confidence 0.61 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2938448 Disease Relevance 1.14 Pain Relevance 0
In the AAV-Tau injected mice, phosphorylation of Tau was evident at many pathological epitopes, including those defined by antibodies AT8, AT100, AT180, and AT270 [30].
Phosphorylation (phosphorylation) of Tau
5) Confidence 0.61 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2938448 Disease Relevance 0.68 Pain Relevance 0.04
At this late time-point, we also observed increased phosphorylation of endogenous mouse protein Tau, particularly at residues T181 and T231, both known to be substrate for GSK3.
Phosphorylation (phosphorylation) of Tau
6) Confidence 0.61 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2938448 Disease Relevance 0.60 Pain Relevance 0.17
The data explain how excess Tau in first instance blocks transport by covering microtubuli, while GSK3 acting as major Tau-kinase I phosphorylates Tau to detach it from the microtubules and relieves the transport blockade [37].
Phosphorylation (phosphorylates) of Tau in covering
7) Confidence 0.61 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2938448 Disease Relevance 0.44 Pain Relevance 0.03
NFT is primarily composed of hyperphosphorylated form of Tau protein [5].
Phosphorylation (hyperphosphorylated) of Tau
8) Confidence 0.61 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915796 Disease Relevance 1.36 Pain Relevance 0
, hyperphosphorylation of Tau and formation of neurofibrillary pathology.


Phosphorylation (hyperphosphorylation) of Tau
9) Confidence 0.61 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2905372 Disease Relevance 1.28 Pain Relevance 0
Suppression of WOX1 expression by small interfering RNA spontaneously
               induces Tau phosphorylation in neuroblastoma cells [1], suggesting a role of WOX1
               in controlling Tau tangle formation. 
Phosphorylation (phosphorylation) of Tau associated with neuroblastoma and eae
10) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771921 Disease Relevance 0.59 Pain Relevance 0.08
Tau is normally phosphorylated in cells with its state of phosphorylation related to developmental state [1].
Phosphorylation (phosphorylated) of Tau
11) Confidence 0.61 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2988785 Disease Relevance 0.29 Pain Relevance 0.05
To rule out that STZ administration may have altered expression level or pattern of transgenic tau, we performed immunohistochemistry of brain sections and Western blotting of brain extracts, using phosphorylation-independent tau specific antibodies, HT7 and TAU5.
Phosphorylation (phosphorylation) of TAU5 in brain associated with targeted disruption
12) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775636 Disease Relevance 0.44 Pain Relevance 0.07
42, total-tau (t-tau), and phosphorylated-tau (p-tau), have been found to have the highest diagnostic potential.
Phosphorylation (phosphorylated) of p-tau
13) Confidence 0.23 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915796 Disease Relevance 0.93 Pain Relevance 0.05
42, total-tau (t-tau), and phosphorylated-tau (p-tau), have been found to have the highest diagnostic potential.
Phosphorylation (phosphorylated) of t-tau
14) Confidence 0.23 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915796 Disease Relevance 0.92 Pain Relevance 0.05

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