INT142075

Context Info Confidence 0.02 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 2.07 Pain Relevance 1.19

cytosol (IDO1) extracellular space (IL4) small molecule metabolic process (IDO1) oxidoreductase activity (IDO1) extracellular region (IL4) cellular nitrogen compound metabolic process (IDO1)

Anatomy Link Frequency fibroblasts 3 monocytes 1 IL4 (Homo sapiens) IDO1 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 10 93.76 Inflammation 12 91.72 cva 4 82.64 headache 18 75.00 Central nervous system 12 54.40 Migraine 2 25.00

Disease Link Frequency Relevance Heat INFLAMMATION 10 91.72 Pseudotumor Cerebri 4 83.52 Viral Meningitis 2 78.48 Headache 20 75.00 Cerebral Toxoplasmosis 4 75.00 Immunodeficiency 4 75.00 Neurogenic Inflammation 2 75.00 Lymphadenopathy 2 75.00 Infection 10 53.28 Neurologic Manifestations 2 46.72

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

On the other hand, IL-4 and TGF-beta can suppress IDO activity in some cells, for example human monocytes and fibroblasts, which is consistent with metabolic pathways controlled by IDO being a significant contributor to the proinflammatory system.

IL-4 Negative_regulation (suppress) of IDO Binding (activity) of in fibroblasts

1) Confidence 0.02 Published 2007 Journal Am J Ther Section Abstract Doc Link 17303977 Disease Relevance 1.04 Pain Relevance 0.60

On the other hand, IL-4 and TGF-beta can suppress IDO activity in some cells, for example human monocytes and fibroblasts, which is consistent with metabolic pathways controlled by IDO being a significant contributor to the proinflammatory system.

IL-4 Negative_regulation (suppress) of IDO in monocytes Binding (activity) of in fibroblasts

2) Confidence 0.01 Published 2007 Journal Am J Ther Section Abstract Doc Link 17303977 Disease Relevance 1.04 Pain Relevance 0.60

General Comments

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