INT142079

Context Info Confidence 0.00 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 1.01 Pain Relevance 0.57

cytosol (AIF1) plasma membrane (AIF1) cytoskeleton (AIF1) nucleus (AIF1) response to stress (AIF1) cytoplasm (AIF1)

AIF1 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 6 100.00 cytokine 5 95.52 headache 9 75.00 cva 2 58.24 Central nervous system 6 44.68 Migraine 1 25.00

Disease Link Frequency Relevance Heat INFLAMMATION 5 100.00 Headache 10 75.00 Cerebral Toxoplasmosis 2 75.00 Immunodeficiency 2 75.00 Neurogenic Inflammation 1 75.00 Lymphadenopathy 1 75.00 Pseudotumor Cerebri 2 59.12 Infection 5 56.80 Viral Meningitis 1 54.08 Urinary Tract Disease 1 34.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Moreover, NO inhibits IDO activity, thereby suppressing kynurenine formation, and at least one member of the kynurenine pathway, 3-hydroxyanthranilic acid, has been shown to inhibit NOS enzyme activity, the expression of NOS mRNA, and activation of the inflammatory transcription factor, nuclear factor-kB.

Negative_regulation (inhibit) of Positive_regulation (activation) of inflammatory transcription factor associated with inflammation

1) Confidence 0.00 Published 2007 Journal Am J Ther Section Abstract Doc Link 17303977 Disease Relevance 1.01 Pain Relevance 0.57

General Comments

This test has worked.