INT142080

Context Info Confidence 0.27 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 1.47 Pain Relevance 0.55

cytosol (IDO1) small molecule metabolic process (IDO1) oxidoreductase activity (IDO1) cellular nitrogen compound metabolic process (IDO1)

IDO1 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 6 93.08 Central nervous system 6 91.76 headache 9 86.80 cytokine 6 86.76 tolerance 8 35.04 cva 4 25.00 Migraine 1 25.00 abatacept 3 9.28 fibrosis 2 5.00 rheumatoid arthritis 2 5.00

Disease Link Frequency Relevance Heat Infection 10 97.68 INFLAMMATION 5 93.08 Apoptosis 1 90.16 Headache 10 86.80 Urinary Tract Disease 1 81.88 Immunodeficiency 2 75.00 Cerebral Toxoplasmosis 2 75.00 Lymphadenopathy 1 75.00 Neurogenic Inflammation 1 75.00 Rupture 1 68.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

, which stimulates the indoleamine 2,3-dioxygenase (IDO) to degrade tryptophan.

Protein_catabolism (degrade) of IDO

1) Confidence 0.27 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721321 Disease Relevance 0.09 Pain Relevance 0

This is consistent with significantly lower enzyme indoleamine 2,3-dioxygenase (IDO) activity reported in atopic than in nonatopic individuals, and an important role that IDO and tryptophan degradation pathways plays in both, the host resistance to T. gondii infection and its reactivation.

Protein_catabolism (degradation) of IDO associated with infection

2) Confidence 0.21 Published 2007 Journal Am J Ther Section Abstract Doc Link 17303977 Disease Relevance 1.38 Pain Relevance 0.55

General Comments

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