INT142214

Context Info Confidence 0.48 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

cell proliferation (Glul) mitochondrion (Glul) lyase activity (Glul) Golgi apparatus (Glul) intracellular (Glul) protein complex (Glul)

Glul (Rattus norvegicus)

Pain Link Frequency Relevance Heat Morphine 6 50.00 dexamethasone 3 50.00 Glutamate 3 50.00 tolerance 3 5.00 excitatory amino acid 2 5.00 Spinal cord 1 5.00 intrathecal 1 5.00

|}

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

CONCLUSION: Intrathecal dexamethasone attenuates long-term morphine infusion-induced glutamate dehydrogenase and glutamate synthetase downregulation and antinociceptive tolerance.

Positive_regulation (infusion-induced) of Negative_regulation (downregulation) of glutamate synthetase

1) Confidence 0.48 Published 2007 Journal Anesth. Analg. Section Body Doc Link 17312234 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.