INT142462

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Context Info
Confidence 0.68
First Reported 2005
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 23
Total Number 23
Disease Relevance 23.27
Pain Relevance 8.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Socs3) cytoplasm (Socs3)
Anatomy Link Frequency
T cells 8
lamina 6
macrophages 2
RAG 2
hepatocytes 2
Socs3 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 614 100.00 Very High Very High Very High
Inflammation 537 99.32 Very High Very High Very High
Paracetamol 37 99.04 Very High Very High Very High
rheumatoid arthritis 147 98.68 Very High Very High Very High
Arthritis 145 98.40 Very High Very High Very High
fibrosis 83 97.52 Very High Very High Very High
Crohn's disease 14 92.76 High High
Inflammatory response 29 92.52 High High
Inflammatory stimuli 6 91.84 High High
cINOD 25 82.88 Quite High
Disease Link Frequency Relevance Heat
Synovitis 12 99.52 Very High Very High Very High
Cancer 311 99.40 Very High Very High Very High
INFLAMMATION 554 99.32 Very High Very High Very High
Neuroblastoma 2 98.92 Very High Very High Very High
Injury 45 98.88 Very High Very High Very High
Rheumatoid Arthritis 147 98.68 Very High Very High Very High
Hepatotoxicity 31 98.60 Very High Very High Very High
Targeted Disruption 120 98.58 Very High Very High Very High
Arthritis 167 98.40 Very High Very High Very High
Death 22 98.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alternatively, hepatoprotective STAT3 activation was decreased in SOCS3Tg hepatocytes, an event that was associated with augmented SOCS3 expression in the hepatocytes.
Positive_regulation (augmented) of Gene_expression (expression) of SOCS3 in hepatocytes
1) Confidence 0.68 Published 2007 Journal J. Immunol. Section Abstract Doc Link 17339476 Disease Relevance 0.79 Pain Relevance 0.32
Mice with a cell-specific overexpression of SOCS3 in T cells (SOCS3Tg, in which Tg is transgenic) exhibited exaggerated hepatic injury after APAP challenge, as evidenced by increased serum alanine aminotransferase levels, augmented hepatic necrosis, and decreased survival relative to the wild-type mice.
Positive_regulation (overexpression) of Gene_expression (overexpression) of SOCS3 in T cells associated with targeted disruption, necrosis, paracetamol and injury
2) Confidence 0.68 Published 2007 Journal J. Immunol. Section Abstract Doc Link 17339476 Disease Relevance 0.78 Pain Relevance 0.70
Indeed, that report also describes that increased SOCS3 expression in T cells is correlated with the severity of human allergic diseases such as asthma and atopic dermatitis.
Positive_regulation (increased) of Gene_expression (expression) of SOCS3 in T cells associated with asthma, hypersensitivity, eczema and disease
3) Confidence 0.57 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.84 Pain Relevance 0.36
In a dextran sulfate sodium-induced mouse colitis model, a time-course experiment indicated that STAT3 activation was 1 day ahead of SOCS3 induction; STAT3 activation became apparent during days 3 to 5 and decreased thereafter, whereas SOCS3 expression was induced at day 5 and maintained high levels thereafter.
Positive_regulation (induced) of Gene_expression (expression) of SOCS3 associated with colitis
4) Confidence 0.57 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.58 Pain Relevance 0.44
Overexpression of SOCS3 is observed immediately (3 hours) after intestinal irradiation [89] and the SOCS3 level remains high for a long time after irradiation ends (6 months) [57].
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of SOCS3
5) Confidence 0.51 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.40 Pain Relevance 0.18
However, our study found that low or silenced SOCS3 expression does not occur in the normal mucosa of patients with colorectal adenoma.
Positive_regulation (silenced) of Gene_expression (expression) of SOCS3 associated with adenoma
6) Confidence 0.50 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2883989 Disease Relevance 1.50 Pain Relevance 0.20
However, our study found that low or silenced SOCS3 expression does not occur in the normal mucosa of patients with colorectal adenoma.
Neg (not) Positive_regulation (occur) of Gene_expression (expression) of SOCS3 associated with adenoma
7) Confidence 0.50 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2883989 Disease Relevance 1.49 Pain Relevance 0.20
Altogether, these results suggest that forced expression of SOCS3 in T cells is deleterious in APAP hepatotoxicity by increasing STAT1 activation while decreasing STAT3 activation in hepatocytes, possibly through elevated IFN-gamma and TNF-alpha.
Positive_regulation (forced) of Gene_expression (expression) of SOCS3 in T cells associated with paracetamol and hepatotoxicity
8) Confidence 0.49 Published 2007 Journal J. Immunol. Section Abstract Doc Link 17339476 Disease Relevance 0.72 Pain Relevance 0.32
Adaptive transfer of SOCS3Tg-CD4(+) T cells into T and B cell-deficient RAG-2(-/-) mice resulted in an exacerbated liver injury relative to the control.
Positive_regulation (transfer) of Gene_expression (transfer) of SOCS3Tg in RAG associated with injury
9) Confidence 0.49 Published 2007 Journal J. Immunol. Section Abstract Doc Link 17339476 Disease Relevance 0.84 Pain Relevance 0.64
The expression of STAT3 and SOCS3 mRNA was also significantly increased 24 h after LPS injection in both genotypes compared to the vehicle-injected COX-2+/+ mice (Fig. 6B and 6C), but the increase was significantly higher in COX-2-/- mice than in COX-2+/+ mice.
Positive_regulation (increased) of Gene_expression (expression) of SOCS3 mRNA
10) Confidence 0.48 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.17 Pain Relevance 0.13
In this regard, SOCS3 overexpression has been shown to lead to neuroblastoma cell death [60].
Positive_regulation (overexpression) of Gene_expression (overexpression) of SOCS3 associated with neuroblastoma and death
11) Confidence 0.45 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.58 Pain Relevance 0.45
The expression of socs3 increased by 40 and 90% after 3 and 6 h of IL-6 treatment, respectively (data not shown), although maximal accumulation (fourfold) was detected at 24 h (Fig. 4C).
Positive_regulation (increased) of Gene_expression (expression) of socs3
12) Confidence 0.44 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.32 Pain Relevance 0.11
For instance, epigenetic silencing of the negative regulator SOCS3 occurs in epithelial cancers [47], while other cancers show somatic mutations in Stat3-inactivating phosphatases T and ?
Positive_regulation (occurs) of Gene_expression (silencing) of SOCS3 associated with cancer
13) Confidence 0.43 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.79 Pain Relevance 0.09
STAT3 activation and high SOCS3 expression levels have been found in epithelial and lamina propria cells in the colon of IBD (inflammatory bowel disease) model mice, as well as in human ulcerative colitis and patients with Crohn's disease [76], and in synovial fibroblasts of patients with RA [77].
Positive_regulation (high) of Gene_expression (expression) of SOCS3 in lamina associated with inflammatory bowel disease, crohn's disease, inflammation, rheumatoid arthritis and disease
14) Confidence 0.41 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.79 Pain Relevance 0.55
We have shown that overexpression of SOCS3 by adenoviral gene transfer could prevent the development of experimental arthritis [77].
Positive_regulation (overexpression) of Gene_expression (overexpression) of SOCS3 associated with experimental arthritis and arthritis
15) Confidence 0.41 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.38 Pain Relevance 0.46
In macrophages lacking the SOCS3 gene, or carrying a mutation of the SOCS3 binding site (Y759F) in gp130, not only IL-10 but also IL-6 suppressed LPS-induced TNF-?
Positive_regulation (macrophages) of Neg (lacking) Gene_expression (lacking) of SOCS3 gene in macrophages
16) Confidence 0.41 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.44 Pain Relevance 0.36
On the basis of the evidence that forced expression of SOCS3 can inhibit IL-6-mediated STAT3 activation, we propose that SOCS3 is a negative regulator of inflammatory diseases in synovial fibroblasts, especially in those in which IL-6 levels are very high.
Positive_regulation (forced) of Gene_expression (expression) of SOCS3 in fibroblasts associated with inflammation and disease
17) Confidence 0.41 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.47 Pain Relevance 0.45
STAT3 activation and high SOCS3 expression levels have been found in epithelial and lamina propria cells in the colon of IBD (inflammatory bowel disease) model mice, as well as in human ulcerative colitis and patients with Crohn's disease [76], and in synovial fibroblasts of patients with RA [77].
Positive_regulation (high) of Gene_expression (expression) of SOCS3 in lamina associated with inflammatory bowel disease, crohn's disease, inflammation, rheumatoid arthritis and disease
18) Confidence 0.41 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.79 Pain Relevance 0.55
In murine models of inflammatory synovitis, STAT3 phosphorylation preceded SOCS3 expression, which is consistent with the idea that SOCS3 is part of the STAT3 negative-feedback loop [76].
Positive_regulation (preceded) of Gene_expression (expression) of SOCS3 associated with inflammation and synovitis
19) Confidence 0.41 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.45 Pain Relevance 0.44
Overexpression of suppressor of cytokine signaling-3 in T cells exacerbates acetaminophen-induced hepatotoxicity.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of cytokine signaling-3 in T cells associated with paracetamol, hepatotoxicity and cytokine
20) Confidence 0.40 Published 2007 Journal J. Immunol. Section Title Doc Link 17339476 Disease Relevance 0.72 Pain Relevance 0.73

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