INT142496

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 0.70
Pain Relevance 2.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (INPP5E) plasma membrane (INPP5E) cytoskeleton (INPP5E)
cilium (INPP5E) biological_process (INPP5E) lipid metabolic process (INPP5E)
INPP5E (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 6 99.84 Very High Very High Very High
Opioid 9 99.46 Very High Very High Very High
Neurotransmitter 3 92.12 High High
Morphine 18 92.00 High High
agonist 6 75.00 Quite High
opioid receptor 6 75.00 Quite High
Disease Link Frequency Relevance Heat
Schizophrenia 6 98.68 Very High Very High Very High
Post-traumatic Stress Disorder 4 95.24 Very High Very High Very High
Nicotine Addiction 3 65.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results imply that the opioid system is involved in the modulation of PPI and attentional set-shifting in humans and they raise the question whether the opioid system plays a crucial role also in the regulation of PPI and attentional set-shifting in schizophrenia.
Spec (whether) Regulation (regulation) of PPI associated with opioid and schizophrenia
1) Confidence 0.42 Published 2008 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 18272020 Disease Relevance 0.16 Pain Relevance 0.81
Animal and human studies have shown that PPI can be modulated by dopaminergic, serotonergic, and glutamatergic drugs and consequently it was proposed that impaired sensorimotor gating in schizophrenia parallels a central abnormality within the corresponding neurotransmitter systems.
Regulation (modulated) of PPI associated with neurotransmitter and schizophrenia
2) Confidence 0.42 Published 2008 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 18272020 Disease Relevance 0.25 Pain Relevance 0.46
These results imply that the opioid system is involved in the modulation of PPI and attentional set-shifting in humans and they raise the question whether the opioid system plays a crucial role also in the regulation of PPI and attentional set-shifting in schizophrenia.
Regulation (modulation) of PPI associated with opioid and schizophrenia
3) Confidence 0.18 Published 2008 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 18272020 Disease Relevance 0.21 Pain Relevance 0.88
None of the drugs affected PPI.
Regulation (affected) of PPI
4) Confidence 0.13 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 17342169 Disease Relevance 0.07 Pain Relevance 0.50

General Comments

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