INT142621

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Context Info
Confidence 0.70
First Reported 2005
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 38
Total Number 42
Disease Relevance 15.18
Pain Relevance 13.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (CD36) transport (CD36) small molecule metabolic process (CD36)
cell adhesion (CD36) Golgi apparatus (CD36) plasma membrane (CD36)
Anatomy Link Frequency
monocytes 18
macrophages 6
blood 2
THP-1 2
PMN 2
CD36 (Homo sapiens)
Pain Link Frequency Relevance Heat
cOX1 4 100.00 Very High Very High Very High
Adalimumab 2336 99.98 Very High Very High Very High
aspirin 96 99.98 Very High Very High Very High
dexamethasone 68 99.98 Very High Very High Very High
rheumatoid arthritis 769 99.84 Very High Very High Very High
qutenza 3 99.54 Very High Very High Very High
Inflammation 690 99.08 Very High Very High Very High
cytokine 259 98.48 Very High Very High Very High
chemokine 163 98.04 Very High Very High Very High
antagonist 46 93.84 High High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 845 99.84 Very High Very High Very High
Disease 345 99.44 Very High Very High Very High
Primary Sclerosing Cholangitis 13 99.12 Very High Very High Very High
INFLAMMATION 786 99.08 Very High Very High Very High
Apoptosis 34 98.18 Very High Very High Very High
Congenital Anomalies 32 97.76 Very High Very High Very High
Repression 66 97.68 Very High Very High Very High
Increased Venous Pressure Under Development 387 97.56 Very High Very High Very High
Atherosclerosis 224 93.48 High High
Cancer 227 93.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Arvanil and anandamide up-regulate CD36 expression in human peripheral blood mononuclear cells.
Positive_regulation (up-regulate) of Gene_expression (expression) of CD36 in blood associated with qutenza
1) Confidence 0.70 Published 2007 Journal Immunol. Lett. Section Title Doc Link 17360047 Disease Relevance 0 Pain Relevance 0.33
Some therapeutic agents used in human pathology for their anti-inflammatory properties appear to modulate expression of CD36 by monocytes/macrophages and dendritic cells: aspirin induces expression of CD36 by human macrophages while dexamethasone induces expression of CD36 by dendritic cells [23,24].
Positive_regulation (induces) of Gene_expression (expression) of CD36 in macrophages associated with aspirin, inflammation and dexamethasone
2) Confidence 0.68 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.62 Pain Relevance 0.35
The F(ab')2 fragment increases membrane expression of CD36 and induces ROS production, suggesting that F(ab')2 and native antibody use the same signaling pathway.
Positive_regulation (increases) of Gene_expression (expression) of CD36
3) Confidence 0.68 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0 Pain Relevance 0.18
To evaluate the role of redox signaling in the induction of CD36 expression observed with anti-TNF?
Positive_regulation (induction) of Gene_expression (expression) of CD36
4) Confidence 0.68 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0 Pain Relevance 0.49
Some therapeutic agents used in human pathology for their anti-inflammatory properties appear to modulate expression of CD36 by monocytes/macrophages and dendritic cells: aspirin induces expression of CD36 by human macrophages while dexamethasone induces expression of CD36 by dendritic cells [23,24].
Positive_regulation (induces) of Gene_expression (expression) of CD36 in macrophages associated with aspirin, inflammation and dexamethasone
5) Confidence 0.68 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.60 Pain Relevance 0.35
Experimental data show that metabolites produced in an oxidative context increase the expression of CD36 in murine macrophages [21].
Positive_regulation (increase) of Gene_expression (expression) of CD36 in macrophages
6) Confidence 0.68 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.23 Pain Relevance 0.16
Aspirin increases CD36 expression in lines of human THP1 macrophages [23], dexamethasone induces CD36 expression in human dendritic cells from healthy subjects [24] and atorvastatin increases CD36 expression in human monocytes [36,37].
Positive_regulation (induces) of Gene_expression (expression) of CD36 in monocytes associated with aspirin and dexamethasone
7) Confidence 0.68 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.17 Pain Relevance 0.28
Figure 4a shows that adalimumab increased CD36 membrane expression (233.7 ± 43.7 versus 122.8 ± 23.2, +70%, p = 0.02), while GW9662 did not significantly decrease CD36 membrane expression (93.8 ± 31.8 versus 122.8 ± 23.2, -24%, p = 0.2), in comparison to basal conditions.
Positive_regulation (increased) of Gene_expression (expression) of CD36 associated with adalimumab
8) Confidence 0.68 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0 Pain Relevance 0.39
The slightly lower induction of CD36 expression observed with the F(ab')2 fragment in comparison to the native antibody could be explained by a partial alteration of the F(ab')2 fragments during the pepsin digestion process [42].
Positive_regulation (induction) of Gene_expression (expression) of CD36
9) Confidence 0.68 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0 Pain Relevance 0.18
According to the results of our study, the increase in membrane expression of CD36 induced by adalimumab involves a redox signaling pathway via NADPH oxidase activation, but not PPAR?.
Positive_regulation (induced) of Gene_expression (expression) of CD36 associated with adalimumab
10) Confidence 0.68 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.15 Pain Relevance 0.22
The combination of adalimumab and GW9662 did not inhibit the effect of adalimumab on CD36 membrane expression, which remained increased (205.5 ± 24.3 versus 122.8 ± 23.2, +67%, p = 0.003).
Positive_regulation (increased) of Gene_expression (expression) of CD36 associated with adalimumab
11) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0 Pain Relevance 0.45
Our study shows that adalimumab increases both CD36 membrane expression and mRNA expression in human monocytes.
Positive_regulation (increases) of Gene_expression (expression) of CD36 in monocytes associated with adalimumab
12) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.24 Pain Relevance 0.23
To investigate the relative contributions of Fab and Fc fragments in the induction of CD36 membrane expression by adalimumab, monocytes were incubated for 24 h with the F(ab')2 fragment of adalimumab (0.8 ?
Positive_regulation (induction) of Gene_expression (expression) of CD36 in monocytes associated with adalimumab
13) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0 Pain Relevance 0.24
is a transcription factor that plays a key role in inducing membrane expression of CD36 on human monocytes [19], we investigated its implication in the regulation of CD36 expression by TNF?.
Positive_regulation (inducing) of Gene_expression (expression) of CD36 in monocytes
14) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0 Pain Relevance 0.25
R activates NADPH oxidase [30,41], the mechanism by which adalimumab increases membrane expression of CD36 appears independent of its Fc fragment.
Positive_regulation (increases) of Gene_expression (expression) of CD36 associated with adalimumab
15) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.05 Pain Relevance 0.22
g/ml) increased CD36 mRNA expression by 96% (1.96 ± 0.2, p = 0.02) in comparison to basal conditions.


Positive_regulation (increased) of Gene_expression (expression) of CD36
16) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0 Pain Relevance 0.28
The increase in CD36 expression induced by adalimumab reported in our study could contribute to the modulation of cardiovascular risk under anti-TNF?
Positive_regulation (increase) of Gene_expression (expression) of CD36 associated with adalimumab
17) Confidence 0.46 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 1.04 Pain Relevance 0.40
is a transcription factor that plays a key role in inducing membrane expression of CD36 on human monocytes [19], we investigated its implication in the induction of CD36 membrane expression by adalimumab (Figure 4a).
Positive_regulation (inducing) of Gene_expression (expression) of CD36 in monocytes associated with adalimumab
18) Confidence 0.46 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.05 Pain Relevance 0.28
The induction of CD36 expression involves redox signaling via NADPH oxidase activation.
Positive_regulation (induction) of Gene_expression (expression) of CD36
19) Confidence 0.46 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.07 Pain Relevance 0.32
Various products derived from lipid peroxidation induce expression of CD36 by activating regulatory transcription factors, such as nuclear factor erythroid 2-related factor 2 (Nrf2), while vitamin E represses it [20-22].
Positive_regulation (induce) of Gene_expression (expression) of CD36
20) Confidence 0.46 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.64 Pain Relevance 0.31

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